Exploring the Role of Nanoparticles in Dental Materials: A Comprehensive Review
Source abstract
Abstract
In recent decades, the integration of nanotechnology into dentistry has led to groundbreaking advancements in dental materials and applications. This article explores the role of nanoparticles (NPs) in modern dentistry, highlighting their definitions, unique properties, and various applications. The introduction establishes the significance of nanotechnology in dental health care, emphasizing the potential of NPs to transform traditional practices. The overview includes a discussion of the fundamental properties of NPs, which contribute to their effectiveness in dental applications. The article categorizes NPs into three main groups: antimicrobial, therapeutic, and material property-improving NPs, detailing their clinical uses and mechanisms of action. Furthermore, it addresses current innovations in dental products incorporating NPs and examines emerging trends in the field. The research for this review was conducted using high-quality, peer-reviewed scientific databases, including PubMed, Scopus, Web of Science, and Google Scholar, with no time restriction as an inclusion criterion. These databases were selected for their credibility and comprehensive collections of relevant studies. In conclusion, NPs represent a promising avenue for innovation in dental materials and therapeutics. Their unique properties enable the development of enhanced antimicrobial agents, effective drug delivery systems, and improved material performance. However, the risks associated with cytotoxicity and stability must be carefully managed to ensure safe and effective use. Ongoing research is essential to fully understand and optimize the applications of NPs in dentistry, balancing their benefits against potential health risks. As the field advances, the integration of NPs into clinical practice will likely revolutionize approaches to dental care and treatment.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, Lebanon
Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, University of Strasbourg, 67000 Strasbourg, France
Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France
Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca 42160, Mexico
Department of Endodontics and Conservative Dentistry, Faculty of Dental Medicine, University of Strasbourg, 67000 Strasbourg, France
References (100+)
Show source-provided references
1. Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines10.1080/21691401.2018.1452750 ↗
2. Gronwald, B., Kozłowska, L., Kijak, K., Lietz-Kijak, D., Skomro, P., Gronwald, K., and Gronwald, H. (2023). Nanoparticles in Dentistry—Current Literature Review. Coatings, 13.10.3390/coatings13010102 ↗
3. Moraes, G., Zambom, C., and Siqueira, W.L. (2021). Nanoparticles in Dentistry: A Comprehensive Review. Pharmaceuticals, 14.10.3390/ph14080752 ↗
4. The Use of Nanoparticles as Biomaterials in Dentistry10.1016/j.drudis.2018.08.012 ↗
5. Pecci-Lloret, M.P., Gea-Alcocer, S., Murcia-Flores, L., Rodríguez-Lozano, F.J., and Oñate-Sánchez, R.E. (2024). Use of Nanoparticles in Regenerative Dentistry: A Systematic Review. Biomimetics, 9.10.3390/biomimetics9040243 ↗
6. Towards a Definition of Inorganic Nanoparticles from an Environmental, Health and Safety Perspective10.1038/nnano.2009.242 ↗
7. Nanoparticles in Biomedical Applications
8. Ghadiri, M., and Stokes, R. (2020). Nanotechnology in Dentistry: A Comprehensive Review. Materials, 13.
9. Size and Shape Control of Metal Nanoparticles for Reaction Selectivity in Catalysis10.1002/cctc.201200229 ↗
10. Arms, L., Smith, D.W., Flynn, J., Palmer, W., Martin, A., Woldu, A., and Hua, S. (2018). Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles. Front. Pharmacol., 9.10.3389/fphar.2018.00802 ↗
11. ElSheikh, S.K., Eid, E.G., Abdelghany, A.M., and Abdelaziz, D. (2024). Physical/Mechanical and Antibacterial Properties of Composite Resin Modified with Selenium Nanoparticles. BMC Oral Health, 24.10.1186/s12903-024-04965-5 ↗
12. Mercan, D.A., Niculescu, A.G., and Grumezescu, A.M. (2022). Nanoparticles for Antimicrobial Agents Delivery—An Up-to-Date Review. Int. J. Mol. Sci., 23.10.3390/ijms232213862 ↗
13. Capuano, N., Amato, A., Dell’Annunziata, F., Giordano, F., Folliero, V., Di Spirito, F., More, P.R., De Filippis, A., Martina, S., and Amato, M. (2023). Nanoparticles and Their Antibacterial Application in Endodontics. Antibiotics, 12.10.3390/antibiotics12121690 ↗
14. Bossù, M., Saccucci, M., Salucci, A., Di Giorgio, G., Bruni, E., Uccelletti, D., Sarto, M.S., Familiari, G., Relucenti, M., and Polimeni, A. (2019). Enamel Remineralization and Repair Results of Biomimetic Hydroxyapatite Toothpaste on Deciduous Teeth: An Effective Option to Fluoride Toothpaste. J. Nanobiotechnol., 17.10.1186/s12951-019-0454-6 ↗
15. Nanoparticles for Dental Implant Applications: Enhancing Osseointegration
16. Biological, Mechanical, and Adhesive Properties of Universal Adhesives Containing Zinc and Copper Nanoparticles10.1016/j.jdent.2019.01.012 ↗
17. Dentin Bond Strength and Antimicrobial Activities of Universal Adhesives Containing Silver Nanoparticles Synthesized with Rosa canina Extract10.1007/s00784-023-05306-6 ↗
18. Nanoparticle-based targeted drug delivery systems: Applications in cancer therapy
19. Chen, Z., Zhang, H., Yang, X., Zhang, Y., Zhu, G., Yang, J., and Zhang, M. (2020). Multifunctional nanoparticles for cancer diagnosis and therapy. Front. Chem., 8.
20. The application of nanoparticles in oral drug delivery systems
21. Nanotechnology in dentistry: A review of the current literature
22. Ramesh, R., Babu, R.S., Manickam, P., Shyamaladevi, R., and Raja, V.S. (2020). Recent advancements in nanoparticle-based drug delivery systems for cancer therapy: A review. Biotechnol. Rep., 25.
23. Nanoparticles: Structure, Properties, Preparation and Behaviour in Environmental Media10.1007/s10646-008-0213-1 ↗
24. Nanoparticles—A Historical Perspective10.1016/j.ijpharm.2006.10.021 ↗
25. Esposizione a Nanoparticelle nei Laboratori di Ricerca [Nanoparticle Exposure in Research Laboratories]
26. Rahman, A., and Ghosh, M. (2021). Nanoparticles and Their Applications in Dental Materials: An Overview. Nanomaterials, 11.
27. Nanotechnology in Dental Applications
28. Natural Inorganic Nanoparticles—Formation, Fate, and Toxicity in the Environment10.1039/C5CS00236B ↗
29. A Review on the Use of Nanoparticles for Dental Tissue Regeneration
30. Zhang, J., Wang, Y., Zhao, Y., and Chen, H. (2021). The Role of Nanoparticles in Restorative Dentistry. Front. Mater., 8.
31. Recent Advances in Protein-Repellent Adhesives Using Nanotechnology
32. A Review on Nanoparticles: Their Synthesis and Types
33. Nanoparticles in Endodontics: Current Trends and Future Directions
34. Application of Gold Nanoparticles in Biomedical and Drug Delivery10.3109/21691401.2014.955107 ↗
35. Nanotechnology for Controlled Drug Delivery in Dental Treatments
36. Naguib, G., Maghrabi, A.A., Mira, A.I., Mously, H.A., Hajjaj, M., and Hamed, M.T. (2023). Influence of Inorganic Nanoparticles on Dental Materials’ Mechanical Properties: A Narrative Review. BMC Oral Health, 23.10.1186/s12903-023-03652-1 ↗
37. Synthesis and Biomedical Applications of Multifunctional Nanoparticles10.1002/adma.201802309 ↗
38. Nanoparticle-Hydrogel: A Hybrid Biomaterial System for Localized Drug Delivery10.1007/s10439-016-1583-9 ↗
39. European Commission (2022). Commission Recommendation
40. (EU) 2022/1089 of 14 June 2022 on Defining Nanomaterials. Off. J. Eur. Union, L176, 1-4. Available online: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32022H0614%2801%29.
41. Size-Comparison-Bio-Nanoparticles (2024, December 23). Size Comparison of Bio-Nanoparticles: Nanometer Scale Comparison and Nanoparticle Size Comparison Nanotechnology Chart Ruler. Nanotechnology Chart Ruler. Available online: https://www.wichlab.com/nanometer-scale-comparison-nanoparticle-size-comparison-nanotechnology-chart-ruler-2/.
42. Ghosh, A., and Banerjee, S. (2019). Nanoparticles in Medicine: Current Status and Future Directions. Molecules, 24.
43. Baran, I., Alavi, S., Baghery, A., and Vatanpour, M. (2020). Potential Toxicity of Nanoparticles in Dental Applications: A Review. Int. J. Mol. Sci., 21.
44. Titanium Dioxide Nanoparticles: A Risk for Human Health?10.2174/1389557516666160321114341 ↗
45. Antimicrobial Nanoparticles in Dental Applications
46. Nanoparticles in the Environment: Where Do We Come from, Where Do We Go To?10.1186/s12302-018-0132-6 ↗
47. Hydroxyapatite Nanoparticles for Remineralization of Dental Enamel
48. Horikoshi, S., and Serpone, N. (2013). Introduction to Nanotechnology. Nanotechnology for Environmental Decontamination, Springer.10.1002/9783527648122.ch1 ↗
49. Advances in Nanoparticles for Endodontic Regeneration
50. Role of nanoparticles in combating oral biofilms
51. Remineralization of enamel with nanohydroxyapatite and its role in dentistry
52. Nanotechnology in dentistry: Present and future perspectives
53. Cao, G. (2004). Nanostructures and Nanomaterials: Synthesis, Properties and Applications, Imperial College Press.10.1142/9781860945960 ↗
54. Nanobiotechnology and its applications
55. Nanomaterials in dentistry: Applications and toxicological risks
56. Nanoparticle-based drug delivery systems in dentistry
57. Nanotechnology applications in dentistry: A review of recent advances10.1016/j.sdentj.2018.01.002 ↗
58. Bhushan, B. (2017). Springer Handbook of Nanotechnology, Springer. [4th ed.].10.1007/978-3-662-54357-3 ↗
59. Altammar, K. (2023). A review on nanoparticles: Characteristics, synthesis, applications, and challenges. Front Microbiol., 14.10.3389/fmicb.2023.1155622 ↗
60. La, D.D., Truong, T.N., Pham, T.Q., Vo, H.T., Tran, N.T., Nguyen, T.A., Nguyen, T.B., Pham, H.D., Tran, V.T., and Nguyen, D.D. (2020). Scalable Fabrication of Modified Graphene Nanoplatelets as an Effective Additive for Engine Lubricant Oil. Nanomaterials, 10.10.3390/nano10050877 ↗
61. Nanoparticle fabrication using various approaches
62. Top-down and bottom-up approaches for the synthesis of nanomaterials: A review
63. Recent trends in nanoparticle synthesis via top-down approaches
64. Advances in top-down nanoparticle fabrication techniques: Applications and challenges
65. Top-down nanofabrication techniques: Advancements and applications
66. Nanoparticle synthesis: Bottom-up approaches and their advantages in nanotechnology
67. Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size10.1016/j.colsurfb.2008.07.004 ↗
68. Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors10.1186/1479-5876-7-51 ↗
69. Clearance properties of nano-sized particles and molecules as imaging agents: Considerations and caveats10.2217/17435889.3.5.703 ↗
70. Clearance and biodistribution of nanoparticles in vivo
71. Size-dependent biodistribution and clearance of nanoparticles
72. Toxicity of 8 nm and 37 nm silica nanoparticles in murine macrophages
73. Physical Properties of Nanoparticles That Result in Improved Cancer Targeting10.1155/2020/5194780 ↗
74. Nanoparticle shape and its influence on cellular uptake and internalization
75. The role of nanoparticle morphology in cellular uptake
76. Jarai, B.M., and Fromen, C.A. (2022). Nanoparticle Internalization Promotes the Survival of Primary Macrophages. Adv. Nanobiomed Res., 2.10.1002/anbr.202100127 ↗
77. Toxicity of silver nanoparticles: Influence of morphology
78. Role of nanoparticle size, shape, and surface chemistry in oral drug delivery
79. Impact of nanoparticle geometry on cellular uptake and cytotoxicity
80. Biocompatible silica nanoparticles for cancer therapy10.1002/smll.201000538 ↗
81. Amorphous silica nanoparticles impair vascular homeostasis and induce systemic inflammation10.2147/IJN.S52818 ↗
82. Effects of engineered nanoparticles on the innate immune system10.1016/j.smim.2017.09.011 ↗
83. Studies on the biocompatibility and the interaction of silver nanoparticles with human mesenchymal stem cells (hMSCs)10.1007/s00423-009-0472-1 ↗
84. Genotoxicity of amorphous silica nanoparticles: Status and prospects10.1016/j.nano.2018.11.013 ↗
85. Nejati, K., Dadashpour, M., Gharibi, T., Mellatyar, H., and Akbarzadeh, A. (2021). Biomedical applications of functionalized gold nanoparticles: A review. J. Cluster Sci., 1–16.10.1007/s10876-020-01955-9 ↗
86. The role of surface charge in the interactions of nanoparticles with biological systems
87. Nanoparticles: Health effects—Pros and cons10.1289/ehp.8871 ↗
88. Sun, H., Jia, J., Jiang, C., and Zhai, S. (2018). Gold Nanoparticle-Induced Cell Death and Potential Applications in Nanomedicine. Int. J. Mol. Sci., 19.10.3390/ijms19030754 ↗
89. Kopac, T. (2021). The influence of surface charge on the biological interactions of nanoparticles. J. Nanobiotechnol., 19.
90. The evolution of the protein corona around nanoparticles
91. Understanding biophysicochemical interactions at the nano-bio interface10.1038/nmat2442 ↗
92. Implications of Protein Corona on Physico-Chemical and Biological Properties of Magnetic Nanoparticles10.1016/j.biomaterials.2014.12.045 ↗
93. Mechanistic Understanding of Protein Corona Formation Around Nanoparticles: Old Puzzles and New Insights10.1002/smll.202301663 ↗
94. Protein–Nanoparticle Interactions and a New Insight10.1039/D0SM02050H ↗
95. Protein Corona Formation Around Nanoparticles–From the Past to the Future10.1039/C3MH00106G ↗
96. In Vivo Formation of Protein Corona on Gold Nanoparticles. The Effect of Their Size and Shape10.1039/C7NR08322J ↗
97. Lynch, I., and Dawson, K.A. (2020). Protein–Nanoparticle Interactions. Nano-Enabled Medical Applications, Elsevier.10.1201/9780429399039-8 ↗
98. Impact of Silica Nanoparticle Surface Chemistry on Protein Corona Formation and Consequential Interactions with Biological Cells10.1016/j.msec.2017.02.028 ↗
99. Black, J. (2005). Biological Performance of Materials: Fundamentals of Biocompatibility, CRC Press.10.1201/9781420057843 ↗
100. Ratner, B.D. (2015). The Biocompatibility of Implant Materials. Host Response to Biomaterials, Academic Press.10.1016/B978-0-12-800196-7.00003-7 ↗