journal article·2025-08-01Open access

Recent Advances in Non-Enzymatic Glucose Sensors Based on Nanomaterials

Dongfang Yang, Yongjin Chen, Songtao Che, Kai Wang

Coatings· Volume 15· Issue 8

Abstract

The detection of glucose concentration has a wide range of applications and plays a significant role in the fields of the food industry, medical health, and illness diagnostics. The utilization of sensor technology for glucose concentration detection is an effective approach. Glucose sensors utilizing nanomaterials, with high sensitivity, strong resistance to interference, and compact size, exhibit tremendous potential in glucose concentration detection. Traditional enzyme-based sensors exhibit superior selectivity and high sensitivity; however, they are deficient in terms of interference resistance capabilities. With the development of nanotechnology, the performance of glucose sensors has been significantly improved. This review discusses the research progress in non-enzymatic electrochemical glucose nanosensors, including noble metal-based glucose sensors and non-noble transition metal compound-based glucose sensors, as well as the applications of multimetallic materials in nanosensors. Additionally, the application of nanosensors based on fluorescence and colorimetric principles in the detection of glucose concentration is introduced in this review. Finally, a perspective on the challenges and prospects of nanosensors in the field of glucose detection is presented.
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Research context

OpenAlex topics: Electrochemical sensors and biosensors · Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Haojing College of Shaanxi University of Science & Technology, Xi’an 712046, China

School of Electrical Engineering, Weihai Innovation Research Institute, Qingdao University, Qingdao 266000, China

School of Marine Engineering, Dalian Maritime University, Dalian 116033, China

Funding

Youth Innovation Technology Project of Higher School in Shandong Province · Central guidance local funding project · first batch of key projects in Shandong Province’s marine service industry in 2025

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