Biopolymers for Surgical Applications
Source abstract
Abstract
Biopolymers have gained significant attention as a class of polymer materials with a wide range of applications, especially in the medical and pharmaceutical field. Due to particular characteristics, such as biocompatibility, biodegradability, non-toxicity, and functionality, they have become promising candidates for various surgical applications, including as bioadhesives, sealants, wound dressings, sutures, drug carriers, coating materials, etc. Recent research shows that further modification of biopolymers by advanced techniques can improve their functionality i.e., antibacterial activity, cell viability, drug-releasing capability, good wet adhesion performance, and good mechanical properties. This mini review aims to provide a brief report on the type of biopolymers and recent developments regarding their use in various surgical applications.
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Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Morpho-Functional Sciences II—Pharmacology and Clinical Pharmacology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania
3rd Surgery Clinic, Saint Spiridon University Clinical Emergency Hospital, 700111 Iasi, Romania
Leather Engineering Department, Faculty of Engineering, Ege University, Bornova, 35100 Izmir, Turkey
Department of Analytical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy of Iași, 16 University Street, 700115 Iasi, Romania
Department of Surgery, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania
References (80)
Show source-provided references
1. Biopolymer-based functional composites for medical applications10.1016/j.progpolymsci.2016.12.003 ↗
2. Natural origin biodegradable systems in tissue engineering and regenerative medicine: Present status and some moving trends10.1098/rsif.2007.0220 ↗
3. Polymeric scaffolds in tissue engineering application: A review10.1155/2011/290602 ↗
4. Biopolymers Versus Synthetic Polymers
5. Thomas, S., Durand, D., Chassenieux, C., and Jyotishkumar, P. (2013). Biopolymers for Health, Food, and Cosmetic Applications. Handbook of Biopolymer-Based Materials: From Blends and Composites to Gels and Complex Networks, Wiley-VCH. [1st ed.].10.1002/9783527652457 ↗
6. Niaounakis, M. (2015). Medical, Dental, and Pharmaceutical Applications. Biopolymers: Applications and Trends, Elsevier.10.1016/B978-0-323-35399-1.00007-7 ↗
7. Biopolymers in Medical Implants: A Brief Review10.1016/j.proeng.2017.07.034 ↗
8. Cheaburu Yilmaz, C.N., Tuncay-Tanriverdi, S., Ozer, O., and Vasile, C. (2018). Polysaccharide containing gels for pharmaceutical applications. Polymer Gels: Science and Fundamentals, Kumar Thakur, V.K., Thakur, M.K., Eds., Springer.10.1007/978-981-10-6086-1_6 ↗
9. Ciobanu, C.S., Iconaru, S.L., Predoi, D., Trușcă, R.-D., Prodan, A.M., Groza, A., Chifiriuc, M.C., and Beuran, M. (2021). Fabrication of Novel Chitosan–Hydroxyapatite Nanostructured Thin Films for Biomedical Applications. Coatings, 11.10.3390/coatings11121561 ↗
10. Akhtar, M.A., Hadzhieva, Z., Dlouhý, I., and Boccaccini, A.R. (2020). Electrophoretic Deposition and Characterization of Functional Coatings Based on an Antibacterial Gallium (III)-Chitosan Complex. Coatings, 10.10.3390/coatings10050483 ↗
11. Designing of biocompatible and biodegradable chitosan based crosslinked hydrogel for in vitro release of encapsulated povidone-iodine: A clinical translation10.1016/j.ijbiomac.2020.09.031 ↗
12. Inflammation targeted chitosan-based hydrogel for controlled release of diclofenac sodium10.1016/j.ijbiomac.2020.06.133 ↗
13. Chitosan-Based Functional Materials for Skin Wound Repair: Mechanisms and Applications10.3389/fbioe.2021.650598 ↗
14. Khutoryanskiy, V.V., and Georgiou, T.K. (2018). Sodium alginate grafted with poly(N-isopropylacrylamide). Temperature-Responsive Polymers: Chemistry, Properties, and Applications, Wiley.
15. Barbu, A., Neamtu, B., Zahan, M., Iancu, G.M., Bacila, C., and Miresan, V. (2021). Current Trends in Advanced Alginate-Based Wound Dressings for Chronic Wounds. J. Pers. Med., 11.10.3390/jpm11090890 ↗
16. Cheaburu Yilmaz, C.N., Pamfil, D., Vasile, C., Bibire, N., Lupuşoru, R.V., Zamfir, C.L., and Lupușoru, C.E. (2017). Toxicity, Biocompatibil-ity, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy. Polymers, 9.10.3390/polym9040123 ↗
17. Preparation and In-vitro Evaluation of Melatonin Loaded HA/PVA Gel Formulations10.1080/10837450.2016.1268158 ↗
18. Hyaluronic acid—Based wound dressings: A review10.1016/j.carbpol.2020.116364 ↗
19. Collagen Structure–Function Relationships from Solid-State NMR Spectroscopy10.1021/acs.accounts.8b00092 ↗
20. Mathew-Steiner, S.S., Roy, S., and Sen, C.K. (2021). Collagen in Wound Healing. Bioengineering, 8.10.3390/bioengineering8050063 ↗
21. Asakura, T. (2021). Structure of Silk I (Bombyx mori Silk Fibroin before Spinning) -Type II β-Turn, not α-Helix-. Molecules, 26.10.3390/molecules26123706 ↗
22. Development of Small-Diameter Elastin-Silk Fibroin Vascular Grafts10.3389/fbioe.2020.622220 ↗
23. Pollini, M., and Paladini, F. (2020). Bioinspired Materials for Wound Healing, Application: The Potential of Silk Fibroin. Materials, 13.10.3390/ma13153361 ↗
24. Topical application of silk fibroin-based hydrogel in preventing hypertrophic scars10.1016/j.colsurfb.2019.110735 ↗
25. Silk Biomaterials with Vascularization Capacity10.1002/adfm.201504160 ↗
26. Cherng, J.H., Chou, S.C., Chen, C.L., Wang, Y.W., Chang, S.J., Fan, G.Y., Leung, F.S., and Meng, E. (2021). Bacterial Cellulose as a Potential Bio-Scaffold for Effective Re-Epithelialization Therapy. Pharmaceutics, 13.10.3390/pharmaceutics13101592 ↗
27. Stabilized collagen matrix dressing improves wound macrophage function and epithelialization10.1096/fj.201800352R ↗
28. Accelerating healing of excisional wound with alginate hydrogel containing naringenin in rat model10.1007/s13346-020-00731-6 ↗
29. Injectable Self-Healing Natural Biopolymer-Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery10.1002/adfm.202007457 ↗
30. Chen, W., and Abraham, J.M. (2010). Biopolymer System for Tissue Sealing. (7,854,923 B2), U.S. Patent.
31. Sequential Release of Small Extracellular Vesicles from Bilayered Thiolated Alginate/Polyethylene Glycol Diacrylate Hydrogels for Scarless Wound Healing10.1021/acsnano.0c07714 ↗
32. Nanohybrid-Reinforced Gelatin-Ureidopyrimidinone-Based Self-healing Injectable Hydrogels for Tissue Engineering Applications10.1021/acsabm.1c00458 ↗
33. Antifouling Antioxidant Zwitterionic Dextran Hydrogels as Wound Dressing Materials with Excellent Healing Activities10.1021/acsami.0c17744 ↗
34. Conductive, Self-Healing, Adhesive, and Antibacterial Hydrogels Based on Lignin/Cellulose for Rapid MRSA-Infected Wound Repairing10.1021/acsami.1c14608 ↗
35. Tamer, T.M., Collins, M.N., Valachová, K., Hassan, M.A., Omer, A.M., Mohy-Eldin, M.S., Švík, K., Jurčík, R., Ondruška, Ľ., and Biró, C. (2018). MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing. Materials, 11.10.3390/ma11040569 ↗
36. Hemostatic properties of in situ gels composed of hydrophobically modified biopolymers10.1177/0885328218790313 ↗
37. Polycaprolactone-gelatin membrane as a sealant biomaterial efficiently prevents postoperative anastomotic leakage with promoting tissue repair10.1080/09205063.2021.1917107 ↗
38. A silk-based sealant with tough adhesion for instant hemostasis of bleeding tissues10.1039/C9NH00317G ↗
39. The chemistry and engineering of polymeric hydrogel adhesives for wound closure: A tutorial10.1039/C4CS00332B ↗
40. Elastic sealants for surgical applications10.1016/j.ejpb.2015.05.022 ↗
41. Organ Repair, Hemostasis, and In Vivo Bonding of Medical Devices by Aqueous Solutions of Nanoparticles10.1002/anie.201401043 ↗
42. A blood-resistant surgical glue for minimally invasive repair of vessels and heart defects10.1126/scitranslmed.3006557 ↗
43. Biodegradable-Polymer-Blend-Based Surgical Sealant with Body-Temperature-Mediated Adhesion10.1002/adma.201503691 ↗
44. Tough adhesives for diverse wet surfaces10.1126/science.aah6362 ↗
45. Development of alginate and gelatin-based pleural and tracheal sealants10.1016/j.actbio.2021.06.048 ↗
46. Lilly, J.L., Gottipati, A., Cahall, C.F., Agoub, M., and Berron, B.J. (2018). Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings. PLoS ONE, 13.10.1371/journal.pone.0190880 ↗
47. Oxidant-induced dopamine polymerization for multifunctional coatings10.1039/c0py00215a ↗
48. Enhanced bioadhesivity of dopamine-functionalized polysaccharidic membranes for general surgery applications10.1016/j.actbio.2016.08.017 ↗
49. Molecular mechanics of mussel adhesion proteins10.1016/j.jmps.2013.08.015 ↗
50. 3D printing of biomaterials with mussel-inspired nanostructures for tumor therapy and tissue regeneration10.1016/j.biomaterials.2016.10.005 ↗
51. An adhesive and injectable nanocomposite hydrogel of thiolated gelatin/gelatin methacrylate/Laponite® as a potential surgical sealant10.1016/j.jcis.2019.12.048 ↗
52. Kon, K., and Rai, M. (2014). Significance of Surgical Intervention in the Management of Diabetic Foot Infections. Microbiology for Surgical Infections Diagnosis, Prognosis and Treatment, Elsevier.
53. Thomas, S., Balakrishnan, P., and Sreekala, M.S. (2018). Textile-based biomaterials for surgical applications. Fundamental Biomaterials: Polymers, Elsevier.
54. Auer, J., and Stick, J. (2012). Suture materials and patterns. Equine Surgery, Elsevier. [4th ed.].
55. Selecting the best suture material
56. Is Catgut Really Obsolete? Experience with Buried Subcuticular Catgut Sutures in Operative Wounds10.1016/S0377-1237(02)80133-2 ↗
57. Ex-situ fabrication of ZnO nanoparticles coated silk fiber for surgical applications10.1016/j.matchemphys.2019.04.012 ↗
58. Antimicrobial coating of spider silk to prevent bacterial attachment on silk surgical sutures10.1016/j.actbio.2019.09.004 ↗
59. Antimicrobials tethering on suture surface through a hydrogel: A novel strategy to combat postoperative wound infections10.1039/C7RA04888B ↗
60. Fabrication and characterisation of melt-extruded chitosan/keratin/PCL/PEG drug-eluting sutures designed for wound healing10.1016/j.msec.2020.111696 ↗
61. Development of Absorbable, Antibiotic-Eluting Sutures for Ophthalmic Surgery
62. Antibacterial Surgical Silk Sutures Using a High-Performance Slow-Release Carrier Coating System10.1021/acsami.5b06239 ↗
63. Surgical suture releasing macrophage-targeted drug-loaded nanoparticles for an enhanced anti-inflammatory effect10.1039/C7BM00345E ↗
64. Comparative Evaluation of the Efficacy of Surgical Suture Coated with Analgesic versus Conventional Suture for Sustained Local Pain Relief- Pilot Study
65. Bioactive nano yarns as surgical sutures for wound healing10.1016/j.msec.2021.112334 ↗
66. Nanoparticle-coated sutures providing sustained growth factor delivery to improve the healing strength of injured tendons10.1016/j.actbio.2021.01.008 ↗
67. Electroactive and antibacterial surgical sutures based on chitosan-gelatin/tannic acid/polypyrrole composite coating10.1016/j.compositesb.2021.109140 ↗
68. Intrinsically radiopaque and antimicrobial cellulose based surgical sutures from mechanically powerful Agave sisalana plant leaf fibers10.1039/D1BM01316E ↗
69. Tan, G., Xu, J., Chirume, W.M., Zhang, J., Zhang, H., and Hu, X. (2021). Antibacterial and Anti-Inflammatory Coating Materials for Orthopedic Implants: A Review. Coatings, 11.10.3390/coatings11111401 ↗
70. Preliminary Results on Pulsed Laser Deposition of PMMA on Nitinol Substrate
71. Vasile, C. (2019). Nanocoatings: Preparation, Properties, and Biomedical Applications, In Micro and Nano Technologies, Polymeric Nanomaterials in Nanotherapeutics, Elsevier. [1st ed.].
72. Functional behavior of chitosan/gelatin/silica-gentamicin coatings by electrophoretic deposition on surgical grade stainless steel10.1016/j.msec.2020.111062 ↗
73. Silica core–shell particles for the dual delivery of gentamicin and rifamycin antibiotics10.1039/C6TB00281A ↗
74. Direct writing of bio-functional coatings for cardiovascular applications
75. Electrochemical and hydrogen evolution behaviour of a novel nano-cobalt/nano-chitosan composite coating on a surgical 316L stainless steel alloy as an implant10.1016/j.ijhydene.2021.03.018 ↗
76. Muro-Fraguas, I., Sainz-García, A., López, M., Rojo-Bezares, B., Múgica-Vidal, R., Sainz-García, E., Toledano, P., Sáenz, Y., González-Marcos, A., and Alba-Elías, F. (2020). Antibiofilm coatings through atmospheric pressure plasma for 3D printed surgical instruments. Surf. Coat. Technol., 399.10.1016/j.surfcoat.2020.126163 ↗
77. Meshes in a Mess: Mesenchymal Stem Cell-Based Therapies for Soft Tissue Reinforcement10.1016/j.actbio.2018.11.042 ↗
78. Polypropylene-Nanodiamond Composite for Hernia Mesh10.1016/j.msec.2020.110780 ↗
79. Surgical mesh coatings for infection control and temperature sensing: An in-vitro investigation10.1016/j.onano.2021.100032 ↗
80. Marinaro, F., Silva, J.M., Barros, A.A., Aroso, I.M., Gómez-Blanco, J.C., Jardin, I., Lopez, J.J., Pulido, M., de Pedro, M.A., and Reis, R.L. (2021). A Fibrin Coating Method of Polypropylene Meshes Enables the Adhesion of Menstrual Blood-Derived Mesenchymal Stromal Cells: A New Delivery Strategy for Stem Cell-Based Therapies. Int. J. Mol. Sci., 22.10.3390/ijms222413385 ↗