Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure
Source abstract
Abstract
In this study, ZnHAp layers deposited on a Si substrate were obtained by a sol–gel spin-coating procedure. The ZnHAp solutions used to obtain the ZnHAp coatings were investigated by dynamic light scattering (DLS) analysis, ζ-potential, ultrasound measurements, and flame atomic absorption spectrometry (AAS). The average measured hydrodynamic diameter from the DLS analysis, ζ-potential, and ultrasound measurements were analyzed so as to characterize and estimate the stability of the ZnHAp nanoparticles. The AAS results confirmed the presence of zinc in the gels used in the preparation of the ZnHAp layers. The layers were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The XRD results revealed the diffraction peaks of the hexagonal hydroxyapatite in all of the investigated samples. The morphology of the ZnHAp coatings annealed at 500 °C (ZnHAp-500) and 700 °C (ZnHAp-700), which evidenced that no fissures or cracks formed on the surface of the coatings. The biocompatibility assays indicated that the ZnHAp coatings did not present any toxicity towards the HeLa cells. Furthermore, the study regarding the cytotoxicity of the ZnHAp layers against microorganisms emphasized that ZnHAp coatings exhibited an inhibitory effect towards S. aureus bacterial cells and also towards C. albicans fungal cells.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Polymer Surface Interaction Studies · Marine Biology and Environmental Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
HORIBA Jobin Yvon S.A.S., 6-18, rue du Canal, 91165 Longjumeau cédex, France
ISTO, UMR 7327 CNRS Université d’Orléans, 1A rue de la Férollerie, 45071 Orléans CEDEX 2, France
Funding
Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
References (59)
Show source-provided references
1. Current concepts—Treatment of infections associated with surgical implants10.1056/NEJMra035415 ↗
2. Vallet-Regi, M., and Arcos, D. (2008). Biomimetic Nanoceramics in Clinical Use: From Materials to Applications, Royal Society of Chemistry. [1st ed.].10.1039/9781847558923-FP001 ↗
3. In vitro evaluation of glycerol coated iron oxide nanoparticles in solution
4. Candida infections of medical devices10.1128/CMR.17.2.255-267.2004 ↗
5. Fungal biofilms and antimycotics10.2174/138945005774912762 ↗
6. Infections associated with medical devices: Pathogenesis, management and prophylaxis10.2165/00003495-200565020-00003 ↗
7. Predoi, D., Iconaru, S.L., Buton, N., Badea, M.L., and Marutescu, L. (2018). Antimicrobial activity of new materials based on lavender and basil essential oils and hydroxyapatite. Nanomaterials, 8.10.3390/nano8050291 ↗
8. Development and characterization of silver and zinc doped bioceramic layer on metallic implant materials for orthopedic application10.1016/j.ceramint.2015.12.006 ↗
9. Silver coated materials for external fixation devices: In vitro biocompatibility and genotoxicity10.1016/S0142-9612(01)00198-3 ↗
10. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli10.1128/AEM.02001-07 ↗
11. Efficacy of silver-coated medical devices10.1016/S0195-6701(98)90301-2 ↗
12. Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant10.1016/j.ceramint.2015.09.160 ↗
13. Substituted hydroxyapatites with antibacterial properties10.1155/2014/178123 ↗
14. Kumavath, R.N. (2017). Inorganic nanoparticles: Innovative tools for antimicrobial agents. Antibacterial Agents, IntechOpen.10.5772/65630 ↗
15. In vitro antibacterial activity of zinc oxide on a broad range of reference strains of intestinal origin10.1016/j.vetmic.2012.05.013 ↗
16. Enamel based composite layers deposited on titanium substrate with antifungal activity10.1155/2016/4361051 ↗
17. Groza, A., Ciobanu, C.S., Popa, C.L., Iconaru, S.L., Chapon, P., Luculescu, C., Ganciu, M., and Predoi, D. (2016). Structural properties and antifungal activity against Candida albicans biofilm of different composite layers based on Ag/Zn doped hydroxyapatite-polydimethylsiloxanes. Polymers, 8.10.3390/polym8040131 ↗
18. Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100 °C10.1186/1556-276X-6-613 ↗
19. Predoi, D., Iconaru, S.L., Deniaud, A., Chevallet, M., Michaud-Soret, I., Buton, N., and Prodan, A.M. (2017). Textural, structural and biological evaluation of hydroxyapatite doped with zinc at low concentrations. Materials, 10.10.3390/ma10030229 ↗
20. Structural and biological assessment of zinc doped hydroxyapatite nanoparticles10.1155/2016/1062878 ↗
21. Sm:HAp Nanopowders present antibacterial activity against Enterococcus faecalis10.1155/2014/780686 ↗
22. A Study on mechanical properties of PMMA/hydroxyapatite nanocomposite10.4236/eng.2011.38096 ↗
23. Unraveling the mechanical strength of biomaterials used as a bone scaffold in oral and maxillofacial defects10.1016/S1348-8643(18)30005-3 ↗
24. Predoi, D., Iconaru, S.L., and Predoi, M.V. (2018). Bioceramic layers with antifungal properties. Coatings, 8.10.3390/coatings8080276 ↗
25. Preliminary evaluation of the antifungal activity of samarium doped hydroxyapatite thin films
26. Optical properties of bioactive europium doped hydroxyapatite (HAp:Eu3+)
27. Negrila, C.C., Predoi, M.V., Iconaru, S.L., and Predoi, D. (2018). Development of Zinc-doped hydroxyapatite by sol–gel method for medical applications. Molecules, 23.10.3390/molecules23112986 ↗
28. In vivo response of strontium and zinc-based ionomeric cement implants in bone10.1023/A:1014336517741 ↗
29. Role of zinc in bone formation and bone resorption10.1002/(SICI)1520-670X(1998)11:2/3<119::AID-JTRA5>3.0.CO;2-3 ↗
30. Antibacterial effect of zinc oxide/hydroxyapatite coatings prepared by chemical solution deposition10.1016/j.apsusc.2017.09.101 ↗
31. Iconaru, S.L., Prodan, A.M., Buton, N., and Predoi, D. (2017). Structural characterization and antifungal studies of zinc-doped hydroxyapatite coatings. Molecules, 22.10.3390/molecules22040604 ↗
32. Zinc-substituted hydroxyapatite: A biomaterial with enhanced bioactivity and antibacterial properties10.1007/s10856-012-4817-x ↗
33. Biocompatibility and antimicrobial activity of zinc(II)-doped hydroxyapatite, synthesized by a hydrothermal method10.2298/JSC121019131R ↗
34. Preparation of multicomponent thin films by magnetron co-sputtering method: The Cu–Ti case study10.1016/j.vacuum.2019.01.012 ↗
35. Structural properties of V2O5 thin films prepared by vacuum evaporation10.1016/j.mssp.2003.08.017 ↗
36. A sol–gel dip/spin coating method to prepare titanium oxide films10.1016/j.tsf.2013.08.056 ↗
37. Effects of target bias voltage on indium tin oxide films deposited by high target utilisation sputtering10.1016/j.tsf.2007.03.124 ↗
38. Room temperature deposition of p-type arsenic doped ZnO polycrystalline films by laser-assist filtered cathodic vacuum arc technique10.1063/1.2724795 ↗
39. Morphology evolution of ZnO thin films from aqueous solutions and their application to liquefied petroleum gas (LPG) sensor10.1016/j.jallcom.2012.01.082 ↗
40. Electrodeposition of hydroxyapatite coating on magnesium for biomedical applications10.1007/s11998-011-9382-6 ↗
41. Biomedical coatings on magnesium alloys—A review10.1016/j.actbio.2012.04.012 ↗
42. Hydroxyapatite/titania sol–gel coatings on titanium–zirconium alloy for biomedical applications10.1016/j.actbio.2006.10.004 ↗
43. Preparation of mono- and multilayer films of aromatic polyimides using Langmuir-Blodgett technique10.1246/cl.1986.823 ↗
44. Transparent semiconductor zinc oxide thin films deposited on glass substrates by sol-gel process10.1016/j.ceramint.2010.03.005 ↗
45. Flow of a viscous liquid on a rotating disk10.1063/1.1723300 ↗
46. Comparison of UV and IR laser ablation ICP-MS on silicate reference materials and implementation of normalisation factors for quantitative measurements10.1111/j.1751-908X.2001.tb00611.x ↗
47. (2013). ASTM E2149–13a Standard Test Method for Determining the Antimicrobial Activity of Antimicrobial Agents under Dynamic Contact Conditions, ASTM International.
48. Bioinspired phosphorylcholine containing polymer films with silver nanoparticles combining antifouling and antibacterial properties10.1039/c2bm00155a ↗
49. Biomedical properties and preparation of iron oxide-dextran nanostructures by MAPLE technique10.1186/1752-153X-6-17 ↗
50. Determination of the size distribution of lecithin liposomes: A comparative study using freeze fracture, cryoelectron microscopy and dynamic light scattering10.1046/j.1365-2818.1996.1280687.x ↗
51. Continuous crystalline carbonate apatite thin films. A Biomimetic approach10.1021/ja002537i ↗
52. Calcium hydroxyapatite thin films on titanium substrates prepared by ultrasonic spray pyrolysis10.2320/matertrans.46.228 ↗
53. Novel continuous flow synthesis, characterization and antibacterial studies of nanoscale zinc substituted hydroxyapatite bioceramics10.1016/j.ica.2016.07.041 ↗
54. Synthesis and antibacterial property of zinc loaded hydroxyapatite nanorods10.1016/j.matlet.2012.08.115 ↗
55. Characterization and structural analysis of zinc-substituted hydroxyapatites10.1016/j.actbio.2009.04.014 ↗
56. Sol–gel production of bioactive nano-coatings for medical applications. Part 1: An introduction10.2217/17435889.1.3.311 ↗
57. Synthesis, bioactivity and zeta potential investigations of chlorine and fluorine substituted hydroxyapatite10.1016/j.msec.2015.10.002 ↗
58. Biocompatibility and anti-bacterial activity of Zn-containing HA/TiO2 hybrid coatings on Ti substrate10.2485/jhtb.22.311 ↗
59. Pure and zinc doped nano-hydroxyapatite: Synthesis, characterization, antimicrobial and hemolytic studies10.1016/j.jcrysgro.2014.01.062 ↗