β-Ti Alloys for Orthopedic and Dental Applications: A Review of Progress on Improvement of Properties through Surface Modification
Source abstract
Abstract
Ti and Ti alloys have charming comprehensive properties (high specific strength, strong corrosion resistance, and excellent biocompatibility) that make them the ideal choice in orthopedic and dental applications, especially in the particular fabrication of orthopedic and dental implants. However, these alloys present some shortcomings, specifically elastic modulus, wear, corrosion, and biological performance. Beta-titanium (β-Ti) alloys have been studied as low elastic modulus and low toxic or non-toxic elements. The present work summarizes the improvements of the properties systematically (elastic modulus, hardness, wear resistance, corrosion resistance, antibacterial property, and bone regeneration) for β-Ti alloys via surface modification to address these shortcomings. Additionally, the shortcomings and prospects of the present research are put forward. β-Ti alloys have potential regarding implants in biomedical fields.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Titanium Alloys Microstructure and Properties · Orthopaedic implants and arthroplasty · Advanced materials and composites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China
State Key Lab of Powder Metallurgy, Central South University, Changsha 410083, China
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China
Funding
National Natural Science Foundation · Shanghai Science and Technology Project · Medical Engineering Cross Research Foundation of Shanghai Jiao Tong University
References (100+)
Show source-provided references
1. A Review on Biomedical Titanium Alloys: Recent Progress and Prospect10.1002/adem.201801215 ↗
2. Characteristic effects of alloying elements on β solidifying titanium aluminides: A review10.1016/j.heliyon.2020.e04463 ↗
3. Effect of alloying elements on laser surface modification of powder metallurgy to improve surface mechanical properties of beta titanium alloys for biomedical application10.1016/j.jmrt.2021.07.037 ↗
4. A review on alloy composition and synthesis of β-Titanium alloys for biomedical applications10.1016/j.matpr.2020.02.468 ↗
5. An Evaluation of Beta Titanium Alloys for Use in Orthodontic Appliances10.1177/00220345790580020901 ↗
6. Compressive properties and microstructure evolution in NiTiNb alloy with mesh eutectic phase10.1016/j.msea.2020.140434 ↗
7. Ti based biomaterials, the ultimate choice for orthopaedic implants—A review10.1016/j.pmatsci.2008.06.004 ↗
8. Investigation of the factors influencing the tensile behaviour of PM Ti–3Al–2.5V alloy10.1016/j.msea.2014.05.017 ↗
9. Joint replacement components made of hot-forged and surface-treated Ti-6Al-7Nb alloy10.1016/0142-9612(92)90018-J ↗
10. Diffusion bonding of Ti–2.5Al–2.5Mo–2.5Zr and Co–Cr–Mo alloys10.1016/j.jallcom.2011.04.098 ↗
11. Radiographic Risk Factors Associated With Adverse Local Tissue Reaction in Head-Neck Taper Corrosion of Primary Metal-on-Polyethylene Total Hip Arthroplasty10.5435/JAAOS-D-20-00473 ↗
12. Influence of polyetheretherketone coatings on the Ti-13Nb-13Zr titanium alloy’s bio-tribological properties and corrosion resistance10.1016/j.msec.2016.02.043 ↗
13. Microstructure, defects and mechanical behavior of beta-type titanium porous structures manufactured by electron beam melting and selective laser melting10.1016/j.actamat.2016.04.029 ↗
14. Electron Beam Melted Beta-type Ti–24Nb–4Zr–8Sn Porous Structures With High Strength-to-Modulus Ratio10.1016/j.jmst.2016.03.020 ↗
15. Structure and properties of cast binary Ti–Mo alloys10.1016/S0142-9612(99)00114-3 ↗
16. Zha, S. (2006). Study on the Microstructure and Property of New β-Ti28Nb24.5Zr Alloy for Biomedic Applications. [Master’s Thesis, Tianjin University].
17. Microstructures, mechanical, and biological properties of a novel Ti-6V-4V/zinc surface nanocomposite prepared by friction stir processing10.2147/IJN.S154260 ↗
18. Microstructure evolution and superelastic behavior in Ti-35Nb-2Ta-3Zr alloy processed by friction stir processing10.1016/j.actamat.2017.03.079 ↗
19. Superelastic response of low-modulus porous beta-type Ti-35Nb-2Ta-3Zr alloy fabricated by laser powder bed fusion
20. Raza, D., Kumar, G., Uzair, M., Singh, M.K., Sultan, D., and Kumar, R. (2021). Development and heat treatment of β-phase titanium alloy for orthopedic application. Mater. Today Proc.10.1016/j.matpr.2021.03.665 ↗
21. Progress in Development of Beta Titanium Alloys for Biomedical Applications10.1016/B978-0-12-803581-8.10501-6 ↗
22. Superelastic behavior of in-situ eutectic-reaction manufactured high strength 3D porous NiTi-Nb scaffold10.1016/j.scriptamat.2020.02.025 ↗
23. Nanocrystalline beta-Ti alloy with high hardness, low Young’s modulus and excellent in vitro biocompatibility for biomedical applications10.1016/j.msec.2013.04.044 ↗
24. Increased tissue-level storage modulus and hardness with age in male cortical bone and its association with decreased fracture toughness10.1016/j.bone.2021.115949 ↗
25. Design of beta-Titanium microstructures for implant materials10.1016/j.msec.2020.110715 ↗
26. The corrosion–wear behaviour of thermally oxidised CP-Ti and Ti–6Al–4V10.1016/S0043-1648(03)00557-X ↗
27. Corrosion wear fracture of new β type biomedical titanium alloys10.1016/S0921-5093(98)01167-8 ↗
28. Kaur, S., Ghadirinejad, K., and Oskouei, R.H. (2019). An Overview on the Tribological Performance of Titanium Alloys with Surface Modifications for Biomedical Applications. Lubricants, 7.10.3390/lubricants7080065 ↗
29. Comprehensive review on alloy design, processing, and performance of β Titanium alloys as biomedical materials10.1080/09506608.2020.1735829 ↗
30. Bulk and surface design of MAO-treated Ti-15Zr-15Mo-Ag alloys for potential use as biofunctional implants10.1016/j.matlet.2020.127661 ↗
31. Multi-scale hybrid modified coatings on titanium implants for non-cytotoxicity and antibacterial properties10.1039/D1NR02459K ↗
32. A Brief Review on the Evolution of Metallic Dental Implants: History, Design, and Application10.3389/fmats.2021.646383 ↗
33. The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective10.3389/fbioe.2020.00822 ↗
34. A Review on Bio-functionalization of β-Ti Alloys
35. Wang, Q., Zhou, P., Liu, S., Attarilar, S., Ma, R.L., Zhong, Y., and Wang, L. (2020). Multi-Scale Surface Treatments of Titanium Implants for Rapid Osseointegration: A Review. Nanomater, 10.10.3390/nano10061244 ↗
36. Nanostructured Titanium Alloys Surface Modification Technology for Antibacterial and Osteogenic Properties10.2174/1573413716666200217104004 ↗
37. Surface Modification of Titanium and Titanium Alloys: Technologies, Developments, and Future Interests10.1002/adem.201901258 ↗
38. Surface modification techniques of titanium and titanium alloys for biomedical dental applications: A review10.1016/j.matpr.2020.06.163 ↗
39. Review of the Design of Titanium Alloys with Low Elastic Modulus as Implant Materials10.1002/adem.202000555 ↗
40. Open porous dealloying-based biomaterials as a novel biomaterial platform10.1016/j.msec.2018.03.008 ↗
41. Production, characterisation, and cytocompatibility of porous titanium-based particulate scaffolds10.1007/s10856-013-4989-z ↗
42. Prashanth, K., Zhuravleva, K., Okulov, I., Calin, M., Eckert, J., and Gebert, A. (2016). Mechanical and Corrosion Behavior of New Generation Ti-45Nb Porous Alloys Implant Devices. Technologies, 4.10.3390/technologies4040033 ↗
43. Dealloying-based interpenetrating-phase nanocomposites matching the elastic behavior of human bone10.1038/s41598-017-00048-4 ↗
44. Dealloying-based metal-polymer composites for biomedical applications10.1016/j.scriptamat.2017.12.022 ↗
45. Research progress in titanium alloy in the field of orthopaedic implants
46. Tuning microstructure and mechanical properties of open porous TiNb and TiFe alloys by optimization of dealloying parameters10.1016/j.scriptamat.2018.05.029 ↗
47. Berger, S.A., and Okulov, I.V. (2020). Open Porous α + β Titanium Alloy by Liquid Metal Dealloying for Biomedical Applications. Metals, 10.10.3390/met10111450 ↗
48. The rapidly solidified β-type Ti–Fe–Sn alloys with high specific strength and low elastic modulus10.1016/j.jallcom.2019.01.346 ↗
49. A low-cost metastable beta Ti alloy with high elastic admissible strain and enhanced ductility for orthopaedic application10.1016/j.jallcom.2020.155391 ↗
50. Microstructural and mechanical properties of β-type Ti–Mo–Nb biomedical alloys with low elastic modulus10.1016/j.jallcom.2019.152412 ↗
51. Liquid metals dealloying as a general approach for the selective extraction of metals and the fabrication of nanoporous metals: A review10.1016/j.mtcomm.2020.102007 ↗
52. Okulov, I.V., Joo, S.H., Okulov, A.V., Volegov, A.S., Luthringer, B., Willumeit-Romer, R., Zhang, L., Madler, L., Eckert, J., and Kato, H. (2020). Surface Functionalization of Biomedical Ti-6Al-7Nb Alloy by Liquid Metal Dealloying. Nanomater, 10.10.3390/nano10081479 ↗
53. Anomalous compliance of interpenetrating-phase composite of Ti and Mg synthesized by liquid metal dealloying10.1016/j.scriptamat.2020.113660 ↗
54. Influence of forging deformation and heat treatment on microstructure of Ti–xNb–3Zr–2Ta alloys10.1016/j.msec.2011.10.006 ↗
55. Zhang, T., and Liu, C.-T. (2021). Design of titanium alloys by additive manufacturing: A critical review. Adv. Powder Mater.10.1016/j.apmate.2021.11.001 ↗
56. Investigation of Deformation Mechanisms in β-Type Ti-35Nb-2Ta-3Zr Alloy via FSP Leading to Surface Strengthening10.1007/s11661-015-3089-8 ↗
57. Fatigue performance and cyto-toxicity of low rigidity titanium alloy, Ti–29Nb–13Ta–4.6Zr10.1016/S0142-9612(03)00069-3 ↗
58. Effect of laser remelting on microstructural evolution and mechanical properties of Ti-35Nb-2Ta-3Zr alloy10.1016/j.matlet.2019.06.105 ↗
59. Microstructure evolution and mechanical properties of a Ti-35Nb-3Zr-2Ta biomedical alloy processed by equal channel angular pressing (ECAP)10.1016/j.msec.2013.07.010 ↗
60. Application of ultrasonic nanocrystal surface modification (UNSM) technique for surface strengthening of titanium and titanium alloys: A mini review10.1016/j.jmrt.2021.01.013 ↗
61. Tensile and superelastic behaviors of Ti-35Nb-2Ta-3Zr with gradient structure10.1016/j.matdes.2020.108961 ↗
62. Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone10.1155/2011/836587 ↗
63. Design and mechanical properties of new β type titanium alloys for implant materials10.1016/S0921-5093(97)00808-3 ↗
64. Development of new metallic alloys for biomedical applications10.1016/j.actbio.2012.06.037 ↗
65. Wear transition of solid-solution-strengthened Ti–29Nb–13Ta–4.6Zr alloys by interstitial oxygen for biomedical applications10.1016/j.jmbbm.2015.07.001 ↗
66. Laser surface alloying of commercially pure titanium with boron and carbon10.1016/j.optlaseng.2014.01.019 ↗
67. Laser cladding Ti-Ni/TiN/TiW+TiS/WS2 self-lubricating wear resistant composite coating on Ti-6Al-4V alloy10.1016/j.optlastec.2018.12.046 ↗
68. Nanostructured beta-type titanium alloy fabricated by ultrasonic nanocrystal surface modification10.1016/j.ultsonch.2017.03.061 ↗
69. Laser surface treatment of α-β titanium alloy to develop a β -rich phase with very high hardness10.1016/j.jmatprotec.2020.116873 ↗
70. Dry sliding wear mechanisms of the Ti6Al4V alloy10.1016/S0043-1648(96)07454-6 ↗
71. Microstructure and tribocorrosion performance of nanocrystalline TiN graded coating on biomedical titanium alloy10.1016/S1003-6326(19)65011-9 ↗
72. On the mechanism of crater wear in a high strength metastable β titanium alloy10.1016/j.wear.2021.203998 ↗
73. Wear properties of Ti–13Zr–13Nb (wt.%) near β titanium alloy containing 0.5wt.% boron in dry condition, Hank’s solution and bovine serum10.1016/j.msec.2010.05.011 ↗
74. Dry sliding wear behavior of superelastic Ti–10V–2Fe–3Al β-titanium alloy10.1016/j.wear.2015.12.006 ↗
75. Microstructure evolution and wear behavior of titanium alloy under cryogenic dry sliding wear condition10.1016/j.matchar.2020.110385 ↗
76. Effects of sliding velocity on tribo-oxides and wear behavior of Ti–6Al–4V alloy10.1016/j.triboint.2015.02.009 ↗
77. Dry sliding wear behavior of laser clad TiVCrAlSi high entropy alloy coatings on Ti–6Al–4V substrate10.1016/j.matdes.2012.04.049 ↗
78. Impact of scandium on mechanical properties, corrosion behavior, friction and wear performance, and cytotoxicity of a beta-type Ti-24Nb-38Zr-2Mo alloy for orthopedic applications10.1016/j.actbio.2021.07.061 ↗
79. Differences in the effect of surface texturing on the wear loss of β-type Ti–Nb–Ta–Zr and (α+β)-type Ti–6Al–4V ELI alloys in contact with zirconia in physiological saline solution10.1016/j.jmbbm.2021.104808 ↗
80. Microstructure and wear behavior of inductive nitriding layer in Ti–25Nb–3Zr–2Sn–3Mo alloys10.1016/j.surfcoat.2021.127835 ↗
81. Microstructure refinement and enhanced wear-resistance modulated by stress relaxation processing in a metastable β titanium alloy10.1016/j.matchar.2021.111505 ↗
82. Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification10.1016/j.jallcom.2018.05.088 ↗
83. Fabrication of high strength, antibacterial and biocompatible Ti-5Mo-5Ag alloy for medical and surgical implant applications10.1016/j.msec.2019.110165 ↗
84. Mechanical characterization and deformation behavior of β-stabilized Ti-Nb-Sn-Cr alloys10.1016/j.jallcom.2019.04.079 ↗
85. Comparative analysis of corrosion resistance between beta titanium and Ti-6Al-4V alloys: A systematic review10.1016/j.jtemb.2020.126618 ↗
86. Peripheral neuropathy after hip replacement failure: Is vanadium the culprit?10.1016/S0140-6736(12)60273-6 ↗
87. Aluminium in brain tissue in familial Alzheimer’s disease10.1016/j.jtemb.2016.12.001 ↗
88. Improvement of surface properties and corrosion resistance of Ti13Nb13Zr titanium alloy by plasma-sprayed HA/ZnO coatings for biomedical applications10.1016/j.matchemphys.2020.123738 ↗
89. Surface pre-treatments of Ti-Nb-Zr-Ta beta titanium alloy: The effect of chemical, electrochemical and ion sputter etching on morphology, residual stress, corrosion stability and the MG-63 cell response10.1016/j.rinp.2021.104613 ↗
90. Compatibility assessment of new V-free low-cost Ti–4.7Mo–4.5Fe alloy for some biomedical applications10.1016/j.matdes.2016.02.110 ↗
91. Corrosion characterization of titanium alloys by electrochemical techniques10.1016/j.electacta.2005.02.121 ↗
92. Effects of surface nanocrystallization on corrosion resistance of β-type titanium alloy10.1016/S1003-6326(14)63379-3 ↗
93. Surface modification of β-phase Ti implant by hydroaxyapatite mixed electric discharge machining to enhance the corrosion resistance and in-vitro bioactivity10.1016/j.surfcoat.2017.07.040 ↗
94. Characterization of plasma electrolytic oxidation film on biomedical high niobium-containing β-titanium alloy10.1016/j.surfcoat.2018.08.025 ↗
95. The influence of alloy elements in Ti 6Al 4V and Ti 35Nb 2Ta 3Zr on the structure, morphology and properties of MAO coatings10.1016/j.vacuum.2018.08.054 ↗
96. Microstructure evolution and electrochemical properties of TiO2/Ti-35Nb-2Ta-3Zr micro/nano-composites fabricated by friction stir processing10.1016/j.matdes.2019.107680 ↗
97. Enhancing corrosion resistance and biocompatibility of interconnected porous β-type Ti-24Nb-4Zr-8Sn alloy scaffold through alkaline treatment and type I collagen immobilization10.1016/j.apsusc.2019.01.084 ↗
98. Tribocorrosion behavior of beta titanium biomedical alloys in phosphate buffer saline solution10.1016/j.jmbbm.2015.02.016 ↗
99. Engineering the next-generation tin containing beta titanium alloys with high strength and low modulus for orthopedic applications10.1016/j.jmbbm.2017.11.014 ↗
100. Fretting-corrosion behavior of β titanium alloys in simulated synovial fluid10.1016/j.wear.2011.05.010 ↗