Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release
Source abstract
Abstract
The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.
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Research context
OpenAlex topics: Clay minerals and soil interactions · Therapeutic Uses of Natural Elements · Iron oxide chemistry and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Dipartimento di Fisica e Chimica, Università degli Studi di Palermo, Viale delle Scienze, pad. 17, 90128 Palermo, Italy
Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali, INSTM, Via G. Giusti 9, I-50121 Firenze, Italy
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, Kazan, Republic of Tatarstan 420008, Russia
Funding
Ministero dell’Istruzione, dell’Università e della Ricerca · Russian Foundation for Basic Research · Kazan Federal University for the state assignment in the sphere of scientific activities
References (60)
Show source-provided references
1. Hydrogel: Preparation, characterization, and applications: A review10.1016/j.jare.2013.07.006 ↗
2. Methods of synthesis of hydrogels: A review10.1016/j.jsps.2015.03.022 ↗
3. Classification, processing and application of hydrogels: A review10.1016/j.msec.2015.07.053 ↗
4. Magnetic Hydrogels and Their Potential Biomedical Applications10.1002/adfm.201201708 ↗
5. Novel complex gel beads composed of hydrolyzed polyacrylamide and chitosan: An effective adsorbent for the removal of heavy metal from aqueous solution10.1016/j.biortech.2009.10.069 ↗
6. Enhanced Adsorption of Ammonium Using Hydrogel Composites Based on Chitosan and Halloysite10.1080/10601320903394421 ↗
7. Formation of Supramolecular Hydrogels Induced by Inclusion Complexation between Pluronics and α-Cyclodextrin10.1021/ma010742s ↗
8. Controlled release of doxorubicin from pH-responsive microgels10.1016/j.actbio.2012.09.019 ↗
9. A mini review on hydrogels classification and recent developments in miscellaneous applications10.1016/j.msec.2017.05.096 ↗
10. Polysaccharide-based micro/nanohydrogels for delivering macromolecular therapeutics
11. Novel biocompatible polysaccharide-based self-healing hydrogel10.1002/adfm.201401502 ↗
12. Microgel, nanogel and hydrogel–hydrogel semi-IPN composites for biomedical applications: Synthesis and characterization10.1007/s00396-006-1489-4 ↗
13. Drug release behavior of chitosan–montmorillonite nanocomposite hydrogels following electrostimulation10.1016/j.actbio.2008.01.012 ↗
14. Composite Hydrogel Beads Based on Chitosan and Laponite: Preparation, Swelling, and Drug Release Behaviour
15. Insight into halloysite nanotubes-loaded gellan gum hydrogels for soft tissue engineering applications10.1016/j.carbpol.2017.01.064 ↗
16. Preparation of an imogolite/poly(acrylic acid) hybrid gel10.1016/j.jcis.2013.05.039 ↗
17. An assembly of organic-inorganic composites using halloysite clay nanotubes10.1016/j.cocis.2018.01.002 ↗
18. Lisuzzo, L., Cavallaro, G., Parisi, F., Milioto, S., and Lazzara, G. (2018). Colloidal stability of halloysite clay nanotubes. Ceram. Int.10.1016/j.ceramint.2018.07.289 ↗
19. A structural comparison of halloysite nanotubes of different origin by Small-Angle Neutron Scattering (SANS) and Electric Birefringence10.1016/j.clay.2017.12.044 ↗
20. Halloysite Clay Nanotubes for Controlled Release of Protective Agents10.1021/nn800259q ↗
21. Liquid Crystalline Phase Behavior and Sol–Gel Transition in Aqueous Halloysite Nanotube Dispersions10.1021/la402836d ↗
22. Current challenges in clay minerals for drug delivery10.1016/j.clay.2010.01.007 ↗
23. Halloysite clay minerals—A review10.1180/0009855054040180 ↗
24. Characterisation of properties of various halloysites relevant to their use as nanotubes and microfibre fillers10.1016/j.clay.2012.06.014 ↗
25. Exploiting the Colloidal Stability and Solubilization Ability of Clay Nanotubes/Ionic Surfactant Hybrid Nanomaterials10.1021/jp307961q ↗
26. Biopolymer-Targeted Adsorption onto Halloysite Nanotubes in Aqueous Media10.1021/acs.langmuir.7b00600 ↗
27. Halloysite Tubes as Nanocontainers for Anticorrosion Coating with Benzotriazole10.1021/am9002028 ↗
28. Halloysite nanotube with fluorinated lumen: Non-foaming nanocontainer for storage and controlled release of oxygen in aqueous media10.1016/j.jcis.2013.11.026 ↗
29. Release kinetics of 5-aminosalicylic acid from halloysite10.1016/j.colsurfb.2012.12.041 ↗
30. Toxicity of halloysite clay nanotubes in vivo: A Caenorhabditis elegans study10.1039/C4EN00135D ↗
31. Halloysite nanotubule clay for efficient water purification10.1016/j.jcis.2013.05.072 ↗
32. Modified Halloysite Nanotubes: Nanoarchitectures for Enhancing the Capture of Oils from Vapor and Liquid Phases10.1021/am404693r ↗
33. Preparation and Characterization of Silane Coupling Agent Modified Halloysite for Cr(VI) Removal10.1021/ie200951n ↗
34. Adsorption behavior of methylene blue on halloysite nanotubes10.1016/j.micromeso.2007.10.018 ↗
35. Halloysite nanotubes as a fine grained material for heavy metal ions removal in tropical biofiltration systems10.1016/j.clay.2017.12.051 ↗
36. Halloysite Nanotubes Loaded with Calcium Hydroxide: Alkaline Fillers for the Deacidification of Waterlogged Archeological Woods10.1021/acsami.8b09416 ↗
37. Halloysite Nanotubes for Cleaning, Consolidation and Protection10.1002/tcr.201700099 ↗
38. Functional polymer–clay nanotube composites with sustained release of chemical agents10.1016/j.progpolymsci.2013.05.009 ↗
39. Natural Tubule Clay Template Synthesis of Silver Nanorods for Antibacterial Composite Coating10.1021/am200896d ↗
40. Chitosan-halloysite nanotubes nanocomposite scaffolds for tissue engineering10.1039/c3tb20084a ↗
41. Zhang, H., Cheng, C., Song, H., Bai, L., Cheng, Y., Ba, X., and Wu, Y. (2019). A facile one-step grafting of polyphosphonium onto halloysite nanotubes initiated by Ce(iv). Chem. Commun.10.1039/C8CC08667B ↗
42. Smart H2O2-Responsive Drug Delivery System Made by Halloysite Nanotubes and Carbohydrate Polymers10.1021/acsami.7b10867 ↗
43. Enhanced efficiency of antiseptics with sustained release from clay nanotubes10.1039/C3RA45011B ↗
44. Dendrimer-functionalized halloysite nanotubes for effective drug delivery10.1016/j.clay.2017.12.019 ↗
45. PLA/Halloysite Nanocomposite Films: Water Vapor Barrier Properties and Specific Key Characteristics10.1002/mame.201200424 ↗
46. Physico-chemical characterisation of chitosan/halloysite composite membranes10.1016/j.polymertesting.2012.11.006 ↗
47. Modified natural halloysite/potato starch composite films10.1016/j.carbpol.2011.11.057 ↗
48. Halloysite nanotubes loaded with peppermint essential oil as filler for functional biopolymer film10.1016/j.carbpol.2016.07.041 ↗
49. Sun, P., Liu, G., Lv, D., Dong, X., Wu, J., and Wang, D. (2016). Simultaneous improvement in strength, toughness, and thermal stability of epoxy/halloysite nanotubes composites by interfacial modification. J. Appl. Polym. Sci., 133.10.1002/app.43249 ↗
50. Kim, M., Kim, S., Kim, T., Lee, D.K., Seo, B., and Lim, C.-S. (2017). Mechanical and Thermal Properties of Epoxy Composites Containing Zirconium Oxide Impregnated Halloysite Nanotubes. Coatings, 7.10.3390/coatings7120231 ↗
51. Selective adsorption of oppositely charged PNIPAAM on halloysite surfaces: A route to thermo-responsive nanocarriers10.1088/1361-6528/aac5c3 ↗
52. Cavallaro, G., Danilushkina, A.A., Evtugyn, V.G., Lazzara, G., Milioto, S., Parisi, F., Rozhina, E.V., and Fakhrullin, R.F. (2017). Halloysite Nanotubes: Controlled Access and Release by Smart Gates. Nanomaterials, 7.10.3390/nano7080199 ↗
53. Nanohydrogel Formation within the Halloysite Lumen for Triggered and Sustained Release10.1021/acsami.7b19361 ↗
54. The application of halloysite tubule nanoclay in drug delivery10.1517/17425247.2016.1169271 ↗
55. Alginate gel beads filled with halloysite nanotubes10.1016/j.clay.2012.12.001 ↗
56. Lisuzzo, L., Cavallaro, G., Lazzara, G., Milioto, S., Parisi, F., and Stetsyshyn, Y. (2018). Stability of Halloysite, Imogolite, and Boron Nitride Nanotubes in Solvent Media. Appl. Sci., 8.10.3390/app8071068 ↗
57. Nanocomposites based on esterified colophony and halloysite clay nanotubes as consolidants for waterlogged archaeological woods10.1007/s10570-017-1369-8 ↗
58. Preparation and Drug Retention of Biodegradable Chitosan Gel Beads10.1248/cpb.47.1494 ↗
59. Roles for dietary fibre in the upper GI tract: The importance of viscosity10.1016/j.foodres.2015.11.011 ↗
60. Thermal degradation of hepta cyclopentyl, mono phenyl-polyhedral oligomeric silsesquioxane (hcp-POSS)/polystyrene (PS) nanocomposites10.1016/j.polymdegradstab.2012.03.041 ↗