Bioactive Glass—An Extensive Study of the Preparation and Coating Methods
Source abstract
Abstract
Diseases or complications that are caused by bone tissue damage affect millions of patients every year. Orthopedic and dental implants have become important treatment options for replacing and repairing missing or damaged parts of bones and teeth. In order to use a material in the manufacture of implants, the material must meet several requirements, such as mechanical stability, elasticity, biocompatibility, hydrophilicity, corrosion resistance, and non-toxicity. In the 1970s, a biocompatible glassy material called bioactive glass was discovered. At a later time, several glass materials with similar properties were developed. This material has a big potential to be used in formulating medical devices, but its fragility is an important disadvantage. The use of bioactive glasses in the form of coatings on metal substrates allows the combination of the mechanical hardness of the metal and the biocompatibility of the bioactive glass. In this review, an extensive study of the literature was conducted regarding the preparation methods of bioactive glass and the different techniques of coating on various substrates, such as stainless steel, titanium, and their alloys. Furthermore, the main doping agents that can be used to impart special properties to the bioactive glass coatings are described.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, Gh Polizu Street 1-7, 011061 Bucharest, Romania
National Centre for Micro- and Nanomaterials, University Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania
National Centre for Food Safety, University Politehnica of Buharest, Splaiul Independentei 313, 060042 Bucharest, Romania
SC Microsin SRL, Pericle Papahagi Street 51-63, 032364 Bucharest, Romania
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Politehnica University of Bucharest, Gh Polizu Street 1-7, 011061 Bucharest, Romania
Academy of Romanian Scientists, Splaiul Independentei Street 54, District 5, 050094 Bucharest, Romania
References (100+)
Show source-provided references
1. Ylanen, H. (2018). Bioactive glass coatings. Bioactive Glasses. Materials, Properties and Applications, Woodhead Publishing.
2. Bioactive glass coatings: A review10.1179/1743294410Y.0000000008 ↗
3. The story of Bioglass (R)10.1007/s10856-006-0432-z ↗
4. Glass and medicine: The larry hench story10.1111/ijag.12204 ↗
5. Aldo, R., Boccaccini, D.S.B., and Hupa, L. (2017). Bioactive silicate glass in implantable medical devices: From research to clinical applications. Bioactive Glasses. Fundamentals, Technology and Applications, The Royal Society of Chemistry.
6. Electrophoretic deposition of bioglass/graphene oxide composite on Ti-alloy implants for improved antibacterial and cytocompatible properties10.1080/10667857.2019.1648740 ↗
7. Enhanced antimicrobial properties of bioactive glass using strontium and silver oxide nanocomposites10.1080/21870764.2018.1564477 ↗
8. Development of bioactive composite coatings based on combination of PEEK, bioactive glass and Ag nanoparticles with antibacterial properties10.1016/j.surfcoat.2016.03.057 ↗
9. Using machine learning for improving knowledge on antibacterial effect of bioactive glass10.1016/j.ijpharm.2013.06.036 ↗
10. Antibacterial activity of particulate Bioglass (R) against supra- and subgingival bacteria10.1016/S0142-9612(00)00330-6 ↗
11. Future Applications of Bioglass10.1007/978-3-319-44249-5_13 ↗
12. Particulate Bioglass (R) reduces the viability of bacterial biofilms formed on its surface in an in vitro model10.1034/j.1600-0501.2002.130106.x ↗
13. Differential healing response of bone adjacent to porous implants coated with hydroxyapatite and 45S5 bioactive glass10.1002/1097-4636(20010615)55:4<603::AID-JBM1054>3.0.CO;2-N ↗
14. Migonney, V. (2014). History of biomaterials. Biomaterials, John Wiley & Sons, Inc.10.1002/9781119043553 ↗
15. Bioactive Glass: Chronology, Characterization, and Genetic Control of Tissue Regeneration10.1007/978-3-642-53980-0_3 ↗
16. Biotribological performance of NCD coated Si3N4-bioglass composites10.1016/j.diamond.2006.12.045 ↗
17. Improvement of the balance between a reduced stress shielding and bone rit ingrowth by bioactive coatings onto porous titanium substrates10.1016/j.surfcoat.2018.01.019 ↗
18. Electrophoretic bilayer deposition of zirconia and reinforced bioglass system on Ti6Al4V for implant applications: An in vitro investigation10.1016/j.msec.2013.06.010 ↗
19. Mechanical, tribological and biological properties of novel 45S5 Bioglass (R) composites reinforced with in situ reduced graphene oxide10.1016/j.jmbbm.2016.08.007 ↗
20. Bioactive glass microspheres as osteopromotive inlays in macrotextured surfaces of Ti and CoCr alloy bone implants: Trapezoidal surface grooves without inlay most efficient in resisting torsional forces10.1016/j.jmbbm.2011.05.018 ↗
21. Bioactive glass enhances bone ingrowth into the porous titanium coating on orthopaedic implants10.1007/s00264-012-1520-y ↗
22. Effect of Al3+ ions substitution in novel zinc phosphate glasses on formation of HAp layer for bone graft applications10.1016/j.colsurfb.2019.110591 ↗
23. Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry10.2147/IJN.S123236 ↗
24. Bioactive-glass in periodontal surgery and implant dentistry10.4012/dmj.2014-233 ↗
25. Chitosan-based bioglass composite for bone tissue healing: Oxidative stress status and antiosteoporotic performance in a ovariectomized rat model10.1007/s11814-014-0072-9 ↗
26. Antioxidative/oxidative effects of strontium-doped bioactive glass as bone graft. In vivo assays in ovariectomised rats10.2478/v10136-012-0009-8 ↗
27. Human osteoblast-like cells (MG63) proliferate on a bioactive glass surface10.1002/(SICI)1097-4636(19971205)37:3<394::AID-JBM10>3.0.CO;2-C ↗
28. Current Perspectives: Calcium Phosphate Nanocoatings and Nanocomposite Coatings in Dentistry10.1177/0022034513497754 ↗
29. Systematic Review of Current Dental Implant Coating Materials and Novel Coating Techniques10.11607/ijp.4124 ↗
30. Special Applications of Bioactive Glasses in Otology and Ophthalmology10.1007/978-3-319-44249-5_9 ↗
31. Chronology of Bioactive Glass Development and Clinical Applications10.4236/njgc.2013.32011 ↗
32. Bioactive materials10.1016/0272-8842(95)00126-3 ↗
33. Quantitative comparison of bone growth behavior ingranules of Bioglasst, A-W glass-ceramic, and hydroxyapatite10.1002/(SICI)1097-4636(200007)51:1<37::AID-JBM6>3.0.CO;2-T ↗
34. Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution10.1002/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D ↗
35. Baino, F., and Yamaguchi, S. (2020). The Use of Simulated Body Fluid (SBF) for Assessing Materials Bioactivity in the Context of Tissue Engineering: Review and Challenges. Biomimetics, 5.10.3390/biomimetics5040057 ↗
36. Coatings of titanium substrates with xCaO center dot (1−x)SiO2 sol-gel materials: Characterization, bioactivity and biocompatibility evaluation10.1016/j.msec.2015.09.033 ↗
37. Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications10.1021/acs.biomac.7b00078 ↗
38. Multi-functional bismuth-doped bioglasses: Combining bioactivity and photothermal response for bone tumor treatment and tissue repair10.1038/s41377-018-0007-z ↗
39. In vivo biological performance of a novel highly bioactive glass-ceramic (Biosilicate (R)): A biomechanical and histomorphometric study in rat tibial defects10.1002/jbm.b.31795 ↗
40. Development and bioactivity evaluation of bioglasses with low Na2O content based on the system Na2O-CaO-MgO-P2O5-SiO210.1007/s10856-012-4681-8 ↗
41. Bioactive glasses as delivery systems for antimicrobial agents10.1111/jam.13393 ↗
42. Macro-to-micro porous special bioactive glass and ceftriaxone-sulbactam composite drug delivery system for treatment of chronic osteomyelitis: An investigation through in vitro and in vivo animal trial10.1007/s10856-010-4221-3 ↗
43. Early peri-implant osteogenesis with functionally graded nanophase hydroxyapatite/bioglass coating on Ti alloys10.4028/www.scientific.net/KEM.330-332.553 ↗
44. Phosphate bioglass thin-films: Cross-area uniformity, structure and biological performance tailored by the simple modification of magnetron sputtering gas pressure10.1016/j.apsusc.2020.148640 ↗
45. Multifunctional gradient coatings of phosphate-free bioactive glass on SS316L biomedical implant materials for improved fixation10.1016/j.surfcoat.2013.12.072 ↗
46. Fabrication and Biocompatibility of a Porous Bioglass Ceramic in a Na2o-Cao-Sio2-P2o5 System10.1016/0141-5425(91)90115-N ↗
47. Surface modification of titanium implants using bioactive glasses with air abrasion technologies10.1007/s10856-007-3137-z ↗
48. Skallevold, H.E., Rokaya, D., Khurshid, Z., and Zafar, M.S. (2019). Bioactive Glass Applications in Dentistry. Int. J. Mol. Sci., 20.10.3390/ijms20235960 ↗
49. Bioactive glasses and glass-ceramics
50. Bioactive and mechanically strong Bioglass (R)-poly(D,L-lactic acid) composite coatings on surgical sutures10.1002/jbm.b.30379 ↗
51. Thinfilm deposition and characteristics of calcium-silicates bioglass10.4028/www.scientific.net/KEM.342-343.649 ↗
52. Evaluation of CaO-SiO2-P2O5-Na2O-Fe2O3 bioglass-ceramics for hyperthermia application10.1007/s10856-008-3497-z ↗
53. Determination of relative in vivo osteoconductivity of modified potassium fluorrichterite glass-ceramics compared with 45S5 bioglass10.1007/s10856-012-4707-2 ↗
54. Fabrication and characterization of porous biomedical Vitallium alloy with 58S bioglass coating prepared by sol-gel method10.1016/j.apsusc.2019.144959 ↗
55. Preparation and in vivo biocompatibility studies of different mesoporous bioactive glasses10.1016/j.jmbbm.2018.09.024 ↗
56. Customized Borosilicate Bioglass Scaffolds With Excellent Biodegradation and Osteogenesis for Mandible Reconstruction10.3389/fbioe.2020.610284 ↗
57. Synthesis and characterisation of nanostructured hardystonite coating on stainless steel for biomedical application10.1049/iet-nbt.2017.0275 ↗
58. Structural and microstructural studies of zinc-doped glasses from NaCaPO4-SiO2 system10.1016/j.jnoncrysol.2016.03.013 ↗
59. Biomimetic formation of apatite on the surface of porous gelatin/bioactive glass nanocomposite scaffolds10.1016/j.apsusc.2010.09.008 ↗
60. New Approach to Bone Tissue Engineering: Simultaneous Application of Hydroxyapatite and Bioactive Glass Coated on a Poly(L-lactic acid) Scaffold10.1021/am201212u ↗
61. In vitro dissolution of melt-derived 45S5 and sol-gelderived 58S bioactive glasses10.1002/jbm.10207 ↗
62. Porous chitosan/ZnO-doped bioglass composites as carriers of bioactive peptides10.1111/ijac.13609 ↗
63. Comparative bioactivity study of 45S5 and 58S bioglasses in organic and inorganic environment10.4303/bda/D110154 ↗
64. Bioactivity and hemocompatibility of sol-gel bioactive glass synthesized under different catalytic conditions10.1039/D0NJ02445G ↗
65. A comparative study between melt-derived and sol-gel synthesized 45S5 bioactive glasses10.4028/www.scientific.net/KEM.541.15 ↗
66. In-vitro mechanical and biological evaluation of novel zirconia reinforced bioglass scaffolds for bone repair10.1016/j.jmbbm.2020.104164 ↗
67. Teghil, R., Curcio, M., and De Bonis, A. (2021). Substituted Hydroxyapatite, Glass, and Glass-Ceramic Thin Films Deposited by Nanosecond Pulsed Laser Deposition (PLD) for Biomedical Applications: A Systematic Review. Coatings, 11.10.3390/coatings11070811 ↗
68. Bioglass Coatings and Bioglass Composites as Implant Materials10.1002/jbm.820190309 ↗
69. Surface bio-modification of titanium implants by an enamel process
70. Studies on a novel bioactive glass and composite coating with hydroxyapatite on titanium based alloys: Effect of gamma-sterilization on coating10.1016/j.jeurceramsoc.2009.02.013 ↗
71. Silicate glass coatings on Ti-based implants10.1016/S1359-6454(98)80039-6 ↗
72. The Biological and Biomechanical Properties of Metal Implants Coated with Bioglass Ceramic, as Exemplified in the Simple-Model of a Loaded, Cement-Free Total Hip-Prosthesis10.1515/bmte.1982.27.1-2.24 ↗
73. The Bonding of Bioglass to a Cobalt-Chromium Surgical Implant Alloy10.1016/0142-9612(86)90064-5 ↗
74. Clinical-Application of Dental Implant with Root of Coated Bioglass-Short-Term Results10.1016/0030-4220(90)90171-N ↗
75. Bioactive Double Glass Coatings for Co-Cr-Mo Alloy10.1007/BF00146863 ↗
76. Hench, L.L., and Greenspan, D.C. (1978). Bioglass Coated Al2O3 Ceramics. (4103002), U.S. Patent.
77. Chemical and mechanical behavior of Bioglass coated alumina10.1002/jbm.820100405 ↗
78. Comparative Experimental Investigations with Bioglass LL Hench and Al2O3-Ceramic Coated with Mod Bioglass. II. Results of Experiments with Loaded Implants10.1007/BF00397960 ↗
79. The Loading of Bioglass-Coated Aluminum-Oxide Implants to Produce Sutural Expansion of the Maxillary Complex in the Pigtail Monkey (Macaca-Nemestrina)10.1016/0003-9969(80)90052-7 ↗
80. Bone Dynamics Associated with the Controlled Loading of Bioglass-Coated Aluminum-Oxide Endosteal Implants10.1016/0002-9416(79)90208-2 ↗
81. Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions10.1016/j.biomaterials.2004.07.029 ↗
82. Bioactive and Thermally Compatible Glass Coating on Zirconia Dental Implants10.1177/0022034514559250 ↗
83. Influence of bioactive glass-coating of zirconia implant surfaces on human osteoblast behavior in vitro10.1016/j.dental.2019.02.029 ↗
84. Bioactive glass coatings with hydroxyapatite and Bioglass (R) particles on Ti-based implants. 1. Processing10.1016/S0142-9612(99)00131-3 ↗
85. Bioactive borate glass coatings for titanium alloys10.1007/s10856-008-3419-0 ↗
86. Comparison of bioactive glass coated and hydroxyapatite coated titanium dental implants in the human jaw bone10.1111/j.1834-7819.2010.01305.x ↗
87. Investigation of a bioactive Ti-Co-based brazing coating on oxide high-performance ceramics in medical technology10.1002/mawe.201400268 ↗
88. Clinical Outcome of Hydroxyapatite Coated, Bioactive Glass Coated, and Machined Ti6Al4V Threaded Dental Implant in Human Jaws: A Short-Term Comparative Study10.1097/ID.0000000000000376 ↗
89. Rodriguez, O., Matinmanesh, A., Phull, S., Schemitsch, E.H., Zalzal, P., Clarkin, O.M., Papini, M., and Towler, M.R. (2016). Silica-Based and Borate-Based, Titania-Containing Bioactive Coatings Characterization: Critical Strain Energy Release Rate, Residual Stresses, Hardness, and Thermal Expansion. J. Funct. Biomater., 7.10.3390/jfb7040032 ↗
90. Graded glass coatings for Co-Cr implant alloys10.1007/s10853-005-1982-z ↗
91. Bio-active glass coatings manufactured by thermal spray: A status report10.1016/j.jmrt.2019.07.011 ↗
92. What Do We Know, What are the Current Limitations of Suspension Plasma Spraying?10.1007/s11666-015-0286-3 ↗
93. The Solution Precursor Plasma Spray (SPPS) Process: A Review with Energy Considerations10.1007/s11666-015-0272-9 ↗
94. Karthikeyan, J. (2007). The advantages and disadvantages of the cold spray coating process. The Cold Spray Materials Deposition Process, Woodhead Publishing.10.1201/9781439824122.ch4 ↗
95. Review of Suspension and Solution Precursor Plasma Sprayed Thermal Barrier Coatings10.1016/j.ceramint.2016.06.063 ↗
96. What Do We Know, What are the Current Limitations of Suspension HVOF Spraying?10.1007/s11666-015-0264-9 ↗
97. Bioactivity and mechanical properties of plasma-sprayed coatings ofbioglass powder10.1016/j.surfcoat.2012.11.075 ↗
98. Radiographic and Clinical Outcomes of Porous Titanium-Coated and Plasma-Sprayed Acetabular Shells10.2106/JBJS.17.00729 ↗
99. Effects of composition on crystallization behaviour and mechanical properties of bioactive glass-ceramics in the MgO-CaO-SiO2-P2O5 system10.1016/S0272-8842(99)00072-3 ↗
100. The effect of bond coat on mechanical properties ofplasma sprayed bioglass-titanium coatings10.1016/S0272-8842(03)00107-X ↗