Green Synthesis of Metal and Metal Oxide Nanoparticles Using Different Plants’ Parts for Antimicrobial Activity and Anticancer Activity: A Review Article
Source abstract
Abstract
Nanotechnology emerged as a scientific innovation in the 21st century. Metallic nanoparticles (metal or metal oxide nanoparticles) have attained remarkable popularity due to their interesting biological, physical, chemical, magnetic, and optical properties. Metal-based nanoparticles can be prepared by utilizing different biological, physical, and chemical methods. The biological method is preferred as it provides a green, simple, facile, ecofriendly, rapid, and cost-effective route for the green synthesis of nanoparticles. Plants have complex phytochemical constituents such as carbohydrates, amino acids, phenolics, flavonoids, terpenoids, and proteins, which can behave as reducing and stabilizing agents. However, the mechanism of green synthesis by using plants is still highly debatable. In this report, we summarized basic principles or mechanisms of green synthesis especially for metal or metal oxide (i.e., ZnO, Au, Ag, and TiO2, Fe, Fe2O3, Cu, CuO, Co) nanoparticles. Finally, we explored the medical applications of plant-based nanoparticles in terms of antibacterial, antifungal, and anticancer activity.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Moringa oleifera research and applications · Phytochemistry and Bioactivity Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Chemistry, Faculty of Basic Scieneces and Mathematics, Minhaj University Lahore, Lahore 54700, Pakistan
Department of Allied Health Sciences, Superior University Lahore, Lahore 54700, Pakistan
Department of Chemistry, Forman Christian College Lahore, Lahore 54700, Pakistan
Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia
References (100+)
Show source-provided references
1. Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective10.1038/nnano.2009.242 ↗
2. Biological synthesis of metal nanoparticles by microbes10.1016/j.cis.2010.02.001 ↗
3. Biogenic approach to synthesize rod shaped Gd2O3 nanoparticles and its optimization using response surface methodology-Box–Behnken design model10.1002/btpr.2823 ↗
4. Zinc Oxide Nanoparticles for Revolutionizing Agriculture: Synthesis and Applications10.1155/2014/925494 ↗
5. Ditta, A., Arshad, M., and Ibrahim, M. (2015). Nanoparticles in Sustainable Agricultural Crop Production: Applications and Perspectives. Nanotechnology and Plant Sciences, Springer.10.1007/978-3-319-14502-0_4 ↗
6. Silver nanoparticles: Mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects
7. Large-scale synthesis of copper nanoparticles by chemically controlled reduction for applications of inkjet-printed electronics10.1088/0957-4484/19/41/415604 ↗
8. Bimetallic nanoparticles—novel materials for chemical and physical applications10.1039/a805753b ↗
9. Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications10.1021/cr300068p ↗
10. Selective oxidation of HMF to DFF using Ru/γ-alumina catalyst in moderate boiling solvents toward industrial production10.1016/j.jiec.2012.12.002 ↗
11. Novel one-pot synthesis and characterization of bioactive thiol-silicate nanoparticles for biocatalytic and biosensor applications10.1088/0957-4484/20/5/055612 ↗
12. Staniland, S.S. (2007). Magnetosomes: Bacterial biosynthesis of magnetic nanoparticles and potential biomedical applications. Nanotechnol. Life Sci. Online, 2011.
13. Application of nanoparticles in electrochemical sensors and biosensors
14. Nanoparticles in modern medicine: State of the art and future challenges
15. Detection of Trace Melamine in Raw Materials Used for Protein Pharmaceutical Manufacturing Using Surface-Enhanced Raman Spectroscopy (SERS) with Gold Nanoparticles10.1366/10-06089 ↗
16. Nanoparticles for catalysis10.1021/ar400148q ↗
17. Cao, G., and Wang, Y. (2004). Nanostructures and Nanomaterials: Synthesis, Properties Applications, Imperial College Press.10.1142/9781860945960 ↗
18. Nanotechnology: An innovation in scientific research and technology
19. Tshoko, S. (2019). Spectroelectrochemical Graphene-Silver/Zinc Oxide Nanoparticulate Phenotype Biosensors for Ethambutol and Pyrazinamide. [Master’s Thesis, University of the Western Cape].
20. Green synthesis of metal and metal oxide nanoparticles from plant leaf extracts and their applications: A review10.1515/gps-2020-0031 ↗
21. Clark, J.H., and Macquarrie, D.J. (2008). Handbook of Green Chemistry and Technology, Wiley.
22. What is sustainable development? Goals, indicators, values, and practice10.1080/00139157.2005.10524444 ↗
23. Energy, environment and sustainable development10.1016/j.rser.2007.05.001 ↗
24. Toward a new US chemicals policy: Rebuilding the foundation to advance new science, green chemistry, and environmental health10.1289/ehp.0800404 ↗
25. Crowl, D.A., and Louvar, J.F. (2001). Chemical Process Safety: Fundamentals with Applications, Pearson Education.
26. Green chemistry: Principles and practice10.1039/B918763B ↗
27. Cavani, F., Centi, G., Perathoner, S., and Trifiró, F. (2009). From green to sustainable industrial chemistry. Sustainable Industrial Chemistry, Wiley.10.1002/9783527629114 ↗
28. A review of optimal designs in relation to supply chains and sustainable chemical processes
29. Pal, G., Rai, P., and Pandey, A. (2019). Green synthesis of nanoparticles: A greener approach for a cleaner future. Green Synthesis, Characterization and Applications of Nanoparticles, Elsevier.10.1016/B978-0-08-102579-6.00001-0 ↗
30. Biosynthesis of nanoparticles: Technological concepts and future applications10.1007/s11051-007-9275-x ↗
31. Biosynthesis of nanoparticles using microbes—a review10.1016/j.colsurfb.2014.05.027 ↗
32. Green synthesis of metal nanoparticles using plants10.1039/c1gc15386b ↗
33. A nanometre-scale electronic switch consisting of a metal cluster and redox-addressable groups10.1038/35040518 ↗
34. Docetaxel-loaded solid lipid nanoparticles: A novel drug delivery system10.1049/iet-nbt.2017.0001 ↗
35. Stable and reproducible synthesis of gold nanorods for biomedical applications: A comprehensive study10.1049/iet-nbt.2016.0220 ↗
36. Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from Justicia glauca against oral pathogens: A nanoantibiotic approach10.1016/j.micpath.2017.10.055 ↗
37. Sageretia thea (Osbeck.) mediated synthesis of zinc oxide nanoparticles and its biological applications10.2217/nnm-2017-0124 ↗
38. Applications of plant terpenoids in the synthesis of colloidal silver nanoparticles10.1016/j.cis.2016.04.008 ↗
39. Green chemistry approach for the synthesis and stabilization of biocompatible gold nanoparticles and their potential applications in cancer therapy10.1088/0957-4484/23/45/455103 ↗
40. Potential therapeutic and diagnostic applications of one-step in situ biosynthesized gold nanoconjugates (2-in-1 system) in cancer treatment10.1039/c2ra22299j ↗
41. Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system)10.7150/thno.7819 ↗
42. A green chemistry approach for the synthesis of gold nanoconjugates that induce the inhibition of cancer cell proliferation through induction of oxidative stress and their in vivo toxicity study10.1039/C5TB00244C ↗
43. Green synthesis and characterization of monodispersed gold nanoparticles: Toxicity study, delivery of doxorubicin and its bio-distribution in mouse model10.1166/jbn.2016.2141 ↗
44. Extraction optimization, total phenolic, flavonoid contents, HPLC-DAD analysis and diverse pharmacological evaluations of Dysphania ambrosioides (L.) Mosyakin & Clemants10.1080/14786419.2018.1437428 ↗
45. Synthesis of gold nanoparticles using various amino acids10.1016/j.jcis.2014.12.046 ↗
46. A single-step synthesis of gold nanochains using an amino acid as a capping agent and characterization of their optical properties10.1088/0957-4484/19/7/075601 ↗
47. Amino acid-mediated synthesis of zinc oxide nanostructures and evaluation of their facet-dependent antimicrobial activity10.1016/j.colsurfb.2014.02.017 ↗
48. Green synthesis of silver nanoparticles using Capsicum annuum L. extract10.1039/b615357g ↗
49. Protein-mediated synthesis, pH-induced reversible agglomeration, toxicity and cellular interaction of silver nanoparticles10.1016/j.colsurfb.2012.09.032 ↗
50. Nanoparticles-protein interaction: Role in protein aggregation and clinical implications10.1016/j.ijbiomac.2016.10.024 ↗
51. Soybeans as a phytochemical reservoir for the production and stabilization of biocompatible gold nanoparticles10.1002/smll.200800525 ↗
52. Completely “green” synthesis and stabilization of metal nanoparticles10.1021/ja029267j ↗
53. Microwave-assisted synthesis of silver nanoparticles using sodium alginate and their antibacterial activity10.1016/j.colsurfa.2013.12.008 ↗
54. Sustainable nanomaterials derived from polysaccharides and amphiphilic compounds10.1039/c3sm50358e ↗
55. Green chemistry for nanoparticle synthesis10.1039/C4CS00363B ↗
56. Metal oxides and polysaccharides: An efficient hybrid association for materials chemistry10.1039/C4GC00957F ↗
57. Biosynthesis of Au, Ag and Au–Ag nanoparticles using edible mushroom extract10.1016/j.saa.2009.02.037 ↗
58. Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions10.1002/ptr.5957 ↗
59. Instant green synthesis of silver nanoparticles using Terminalia chebula fruit extract and evaluation of their catalytic activity on reduction of methylene blue10.1016/j.procbio.2012.04.025 ↗
60. Terminalia chebula mediated green and rapid synthesis of gold nanoparticles10.1016/j.saa.2011.11.001 ↗
61. Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology10.1104/pp.126.2.485 ↗
62. Biosynthesis of Gold Nanoparticles by Foliar Broths: Roles of Biocompounds and Other Attributes of the Extracts10.1007/s11671-010-9652-8 ↗
63. Green synthesis of phytochemical-stabilized Au nanoparticles under ambient conditions and their biocompatibility and antioxidative activity10.1039/c1jm11592h ↗
64. Quercetin and gallic acid mediated synthesis of bimetallic (silver and selenium) nanoparticles and their antitumor and antimicrobial potential10.1016/j.jcis.2014.06.030 ↗
65. Synthesis, characterization and biocompatibility of green” synthesized silver nanoparticles using tea polyphenols10.1039/c0nr00046a ↗
66. Biosynthesis of Stable Polyshaped Gold Nanoparticles from Microwave-Exposed Aqueous Extracellular Anti-malignant Guava (Psidium guajava) Leaf Extract10.1007/s12030-009-9030-8 ↗
67. Rapid synthesis of silver nanoparticles using dried medicinal plant of basil10.1016/j.colsurfb.2010.06.029 ↗
68. Green synthesis of silver and gold nanoparticles using Rosa damascena and its primary application in electrochemistry10.1016/j.physe.2011.07.008 ↗
69. ‘Green’synthesis of metals and their oxide nanoparticles: Applications for environmental remediation10.1186/s12951-018-0408-4 ↗
70. Catalytically and biologically active silver nanoparticles synthesized using essential oil10.1016/j.saa.2014.05.046 ↗
71. Rapid biological synthesis of silver nanoparticles using plant leaf extracts10.1007/s00449-008-0224-6 ↗
72. Facile one-pot synthesis of gold and silver nanocatalysts using edible coconut oil10.1016/j.saa.2013.03.076 ↗
73. Fast and Eco-friendly Microwave-Assisted Synthesis of Silver Nanoparticles using Rosemary Essential Oil as Renewable Reducing Agent10.1002/slct.201700244 ↗
74. Synthesis of colloids based on g.old nanoparticles dispersed in castor oil10.1007/s11051-008-9483-z ↗
75. Synthesis characterization and catalytic action of hexagonal gold nanoparticles using essential oils extracted from Anacardium occidentale10.1016/j.saa.2012.06.009 ↗
76. The Advancing of Zinc Oxide Nanoparticles for Biomedical Applications10.1155/2018/1062562 ↗
77. Biosynthesis of zinc oxide nanoparticles using Mangifera indica leaves and evaluation of their antioxidant and cytotoxic properties in lung cancer (A549) cells10.1016/j.enzmictec.2018.06.009 ↗
78. Biotechnological aspects of ZnO nanoparticles: Overview on synthesis and its applications10.1007/s00253-015-7108-x ↗
79. Fabrication of green ZnO nanoparticles using walnut leaf extract to develop an antibacterial film based on polyethylene–starch–ZnO NPs10.1515/gps-2021-0011 ↗
80. Synthesis of zinc oxide nanoparticles using leaf extract of lippiaadoensis (koseret) and evaluation of its antibacterial activity10.1155/2020/7459042 ↗
81. Green synthesis and characterization of zinc oxide nanoparticles using Cayratiapedata leaf extract
82. Biosynthesis of Zinc Oxide Nanoparticles Using Aqueous Piper betle Leaf Extract and Its Application in Surgical Sutures
83. Synthesis and characterization of ZnO nanoparticles using aqueous extract of Becium grandiflorum for antimicrobial activity and adsorption of methylene blue
84. Effective fabrication of zinc-oxide (ZnO) nanoparticles using Achyranthes aspera leaf extract and their potent biological activities against the bacterial poultry pathogens10.1088/2053-1591/abea47 ↗
85. El-Belely, E.F., Farag, M., Said, H.A., Amin, A.S., Azab, E., Gobouri, A.A., and Fouda, A. (2021). Green synthesis of zinc oxide nanoparticles (ZnO-NPs) using Arthrospira platensis (Class: Cyanophyceae) and evaluation of their biomedical activities. Nanomaterials, 11.10.3390/nano11010095 ↗
86. Alamdari, S., Ghamsari, M.S., Lee, C., Han, W., Park, H.-H., Tafreshi, M.J., Afarideh, H., and Ara, M.H.M. (2020). Preparation and Characterization of Zinc Oxide Nanoparticles Using Leaf Extract of Sambucus ebulus. Appl. Sci., 10.10.3390/app10103620 ↗
87. Biosynthesis, characterization, and antibacterial activity of ZnO nanoaggregates using aqueous extract from Anacardium occidentale leaf: Comparative study of different precursors10.1186/s43088-020-00091-7 ↗
88. Green synthesis and characterization of zinc oxide nanoparticles using Eucalyptus globulus Labill. leaf extract and zinc nitrate hexahydrate salt10.1007/s42452-020-2813-1 ↗
89. Green route to synthesize Zinc Oxide Nanoparticles using leaf extracts of Cassia fistula and Melia azadarach and their antibacterial potential10.1038/s41598-020-65949-3 ↗
90. Green synthesis, characterization and anti microbial activities of ZnO nanoparticles using Euphorbia hirta leaf extract10.1016/j.jksus.2020.03.014 ↗
91. Green synthesis, characterization, and biological activities of saffron leaf extract-mediated zinc oxide nanoparticles: A sustainable approach to reuse an agricultural waste10.1002/aoc.5705 ↗
92. Synthesis of ZnO nanoparticles by two different methods comparison of their structural, antibacterial, photocatalytic and optical properties10.1088/2632-959X/ab7a43 ↗
93. Biogenic synthesis and characterization of antimicrobial and anti-parasitic zinc oxide (ZnO) nanoparticles using aqueous extracts of the Himalayan columbine (Aquilegia pubiflora)10.3389/fmats.2020.00249 ↗
94. Green synthesis of ZnO nanoparticles using aqueous Brassica oleracea L. var. italica and the photocatalytic activity10.1080/17518253.2019.1687761 ↗
95. Synthesis of ZnO nanoparticles using insulin-rich leaf extract: Anti-diabetic, antibiofilm and anti-oxidant properties10.1016/j.jphotobiol.2019.111541 ↗
96. Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: Anticancer and antimicrobial activities10.1039/C9RA01659G ↗
97. Green synthesis of zinc oxide nanoparticles using Solanum torvum (L) leaf extract and evaluation of the toxicological profile of the ZnO nanoparticles–hydrogel composite in Wistar albino rats10.1007/s40089-018-0263-1 ↗
98. Rajendran, N., George, B., Houreld, N., and Abrahamse, H. (2021). Synthesis of Zinc Oxide Nanoparticles Using Rubus fairholmianus Root Extract and Their Activity against Pathogenic Bacteria. Molecules, 26.10.3390/molecules26103029 ↗
99. Green synthesis of zinc oxide nanoparticles using the root hair extract of Phoenix dactylifera: Antimicrobial and anticancer activity10.1007/s13204-021-01837-0 ↗
100. Synthesis of ZnO nanoparticles using radish root extract for effective wound dressing agents for diabetic foot ulcers in nursing care10.1016/j.jddst.2019.101364 ↗