Surface Engineering for Bone Implants: A Trend from Passive to Active Surfaces
Source abstract
Abstract
The mechanical and biological properties of bone implants need to be optimal to form a quick and firm connection with the surrounding environment in load bearing applications. Bone is a connective tissue composed of an organic collagenous matrix, a fine dispersion of reinforcing inorganic (calcium phosphate) nanocrystals, and bone-forming and -degrading cells. These different components have a synergistic and hierarchical structure that renders bone tissue properties unique in terms of hardness, flexibility and regenerative capacity. Metallic and polymeric materials offer mechanical strength and/or resilience that are required to simulate bone tissue in load-bearing applications in terms of maximum load, bending and fatigue strength. Nevertheless, the interaction between devices and the surrounding tissue at the implant interface is essential for success or failure of implants. In that respect, coatings can be applied to facilitate the process of bone healing and obtain a continuous transition from living tissue to the synthetic implant. Compounds that are inspired by inorganic (e.g., hydroxyapatite crystals) or organic (e.g., collagen, extracellular matrix components, enzymes) components of bone tissue, are the most obvious candidates for application as implant coating to improve the performance of bone implants. This review provides an overview of recent trends and strategies in surface engineering that are currently investigated to improve the biological performance of bone implants in terms of functionality and biological efficacy.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen 6525, The Netherlands
References (100+)
Show source-provided references
1. Cost-effectiveness of the treatment and prevention of osteoporosis—A review of the literature and a reference model10.1007/s00198-006-0257-0 ↗
2. Advanced biomaterials for skeletal tissue regeneration: Instructive and smart functions10.1016/j.mser.2007.12.001 ↗
3. The use of composite materials in modern orthopaedic medicine and prosthetic devices: A review10.1016/j.compscitech.2011.08.017 ↗
4. Biomedical applications of polymer-composite materials: A review10.1016/S0266-3538(00)00241-4 ↗
5. Measurement of the fatigue life of mini dental implants: A pilot study10.1563/1548-1336(2008)34[7:MOTFLO]2.0.CO;2 ↗
6. Relevance of collagen piezoelectricity to “Wolff’s Law”: A critical review10.1016/j.medengphy.2009.02.006 ↗
7. Foreign body reaction to biomaterials10.1016/j.smim.2007.11.004 ↗
8. The elastic properties of trabecular and cortical bone tissues are similar: Results from two microscopic measurement techniques10.1016/S0021-9290(98)00177-8 ↗
9. Stephani, G., Quadbeck, P., and Andersen, O. (2008, January 10-12). New multifunctional lightweight materials based on cellular metals—Manufacturing,properties and applications. Proceedings of International Conference on Advanced Structural and Functional Materials Design, Osaka, Japan.10.1088/1742-6596/165/1/012061 ↗
10. Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum and rhenium10.1016/S0142-9612(00)00275-1 ↗
11. Mechanical properties of biomedical titanium alloys10.1016/S0921-5093(97)00806-X ↗
12. The Utah paradigm of skeletal physiology: An overview of its insights for bone, cartilage and collagenous tissue organs10.1007/s007740070001 ↗
13. On the mechanisms of biocompatibility10.1016/j.biomaterials.2008.04.023 ↗
14. Physico-chemical considerations of titanium as a biomaterial10.1016/0267-6605(92)90056-Y ↗
15. Predicting clinical biological responses to dental materials10.1016/j.dental.2011.08.595 ↗
16. Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: A review10.1002/jbm.1056 ↗
17. The effect of a nanothickness coating on rough titanium substrate in the osteogenic properties of human bone cells10.1002/jbm.a.32661 ↗
18. Classification of osseointegrated implant surfaces: Materials, chemistry and topography10.1016/j.tibtech.2009.12.003 ↗
19. Advancing dental implant surface technology—From micron- to nanotopography10.1016/j.biomaterials.2008.05.012 ↗
20. Biomaterials, biomechanics, tissue healing, and immediate-function dental implants10.1563/0712.1 ↗
21. Oral implant surfaces: Part 1—Review focusing on topographic and chemical properties of different surfaces and in vivo responses to them
22. Biomaterials: Where we have been and where we are going10.1146/annurev.bioeng.6.040803.140027 ↗
23. Biological responses to materials10.1146/annurev.matsci.31.1.81 ↗
24. A review on calcium phosphate coatings produced using a sputtering process an alternative to plasma spraying10.1016/j.biomaterials.2004.02.029 ↗
25. Hydroxyapatite and their use as coatings in dental implants: A review10.1615/CritRevBiomedEng.v28.i56.10 ↗
26. Effects of implant surface coatings and composition on bone integration: A systematic review10.1111/j.1600-0501.2009.01777.x ↗
27. Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants10.1002/jbm.a.32111 ↗
28. Titanium oral implants: Surface characteristics, interface biology and clinical outcome10.1098/rsif.2010.0118.focus ↗
29. Pulsed laser deposition of hydroxyapatite thin films on Ti-6Al-4V: Effect of heat treatment on structure and properties10.1016/j.actbio.2009.01.027 ↗
30. Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants10.1557/JMR.1998.0015 ↗
31. Calcium phosphate coatings for bio-implant applications: Materials, performance factors, and methodologies10.1016/j.mser.2009.05.001 ↗
32. Differentiation of mesenchymal stem cells onto highly adherent radio frequency-sputtered carbonated hydroxylapatite thin films10.1002/jbm.a.32947 ↗
33. The influence of hydroxyapatite coating of external fixator pins on pin loosening and pin track infection: A systematic review10.1016/j.injury.2009.01.001 ↗
34. Osteointegration of biomimetic apatite coating applied onto dense and porous metal implants in femurs of goats10.1002/jbm.b.10057 ↗
35. Periodontal-type measurements associated with hydroxyapatite-coated and non-HA-coated implants: Uncovering to 36 months10.1902/annals.2000.5.1.56 ↗
36. Investigations of microstructure and properties in bioceramic coatings used in medicine10.2478/v10172-011-0015-y ↗
37. The preparation of calcium phosphate coatings on titanium and nickel-titanium by rf-magnetron-sputtered deposition: Composition, structure and micromechanical properties10.1016/j.surfcoat.2008.01.038 ↗
38. The release of nickel from nickel-titanium (NiTi) is strongly reduced by a sub-micrometer thin layer of calcium phosphate deposited by rf-magnetron sputtering10.1007/s10856-010-3989-5 ↗
39. Plasma-sprayed hydroxyapatite coating on carbon/carbon composite scaffolds for bone tissue engineering and related tests in vivo10.1002/jbm.a.32424 ↗
40. Production and characterization of HA and SiHA coatings10.1007/s10856-009-3841-y ↗
41. Experiment, thermal simulation, and characterizations on transmission laser coating of hydroxyapatite on metal implant10.1002/jbm.a.32325 ↗
42. Structural, microstructural, and residual stress investigations of plasma-sprayed hydroxyapatite on Ti-6Al-4 V10.1021/am900763j ↗
43. The influence of the deposition parameters on the properties of an rf-magnetron-deposited nanostructured calcium phosphate coating and a possible growth mechanism10.1016/j.surfcoat.2010.12.039 ↗
44. Studies on the thermal spraying of apatite bioceramics10.1007/BF02657021 ↗
45. Silicon-substituted hydroxyapatite thin films: Effect of annealing temperature on coating stability and bioactivity10.1002/jbm.a.30730 ↗
46. Production of thin film silicon-doped hydroxyapatite via sputter deposition10.1023/B:JMSC.0000016213.77001.71 ↗
47. Nanostructured Si, Mg, CO32− substituted hydroxyapatite coatings deposited by liquid precursor plasma spraying: Synthesis and characterization10.1007/s11666-011-9628-y ↗
48. Silicon-substituted hydroxyapatite: The next generation of bioactive coatings10.1016/j.msec.2006.05.016 ↗
49. Silicon-substituted hydroxyapatite composite coating by using vacuum-plasma spraying and its interaction with human serum albumin10.1007/s10856-009-3723-3 ↗
50. Evaluation of human osteoblastic cell response to plasma-sprayed silicon-substituted hydroxyapatite coatings over titanium substrates10.1002/jbm.b.31656 ↗
51. Effect of silicon-containing hydroxyapatite coating on human in vitro osteoblastic response10.1016/j.bone.2009.03.464 ↗
52. Thian, E.S., and Best, S.M. (2009). Thin Calcium Phosphate Coatings for Medical Implants, Springer-Verlag.
53. Strontium in the bone-implant interface
54. Preparation and cell-materials interactions of plasma sprayed strontium-containing hydroxyapatite coating10.1016/j.surfcoat.2006.10.012 ↗
55. Laser-Surface Interactions for New Materials Production10.1007/978-3-642-03307-0_10 ↗
56. Strontium-substituted hydroxyapatite coatings synthesized by pulsed-laser deposition: In vitro osteoblast and osteoclast response10.1016/j.actbio.2008.05.005 ↗
57. Biofunctional alendronate-Hydroxyapatite thin films deposited by Matrix Assisted Pulsed Laser Evaporation10.1016/j.biomaterials.2009.07.066 ↗
58. Physicochemical investigation of pulsed laser deposited carbonated hydroxyapatite films on titanium10.1021/am900356e ↗
59. Fluoridated hydroxyapatite/carbon nanotubes composite coating fabricated by radio frequency magnetron sputtering10.4028/www.scientific.net/MSF.675-677.869 ↗
60. Rau, J.V., Smirnov, V.V., Laureti, S., Generosi, A., Varvaro, G., Fosca, M., Ferro, D., Cesaro, S.N., Albertini, V.R., and Barinov, S.M. Properties of pulsed laser deposited fluorinated hydroxyapatite films on titanium. Mater. Res. Bull., 2012 45, 1304–1310.10.1016/j.materresbull.2010.04.028 ↗
61. Microstructure and magnetic properties of a two-phase alloy of α-Fe and metastable Fe3B10.1016/j.jmmm.2008.08.041 ↗
62. Functional coatings or films for hard-tissue applications10.3390/ma3073994 ↗
63. Functionally graded hydroxyapatite coatings doped with antibacterial components10.1016/j.actbio.2009.12.002 ↗
64. Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications10.1016/j.nano.2010.10.005 ↗
65. Antibacterial effects of Ag-HAp thin films on alumina substrates10.1016/S0040-6090(98)00956-0 ↗
66. Silver release from silver-containing hydroxyapatite coatings10.1016/j.surfcoat.2010.08.073 ↗
67. In vivo antibacterial and silver-releasing properties of novel thermal sprayed silver-containing hydroxyapatite coating10.1002/jbm.b.31526 ↗
68. Organic-inorganic surface modifications for titanium implant surfaces10.1007/s11095-008-9617-0 ↗
69. Effects of the platelet-derived growth factor/insulin-like growth factor-I combination on bone regeneration around titanium dental implants. Results of a pilot study in beagle dogs10.1902/jop.1991.62.11.710 ↗
70. Enhancement of bone ingrowth by transforming growth factor-β10.2106/00004623-199508000-00001 ↗
71. Biochemical surface modification of Co-Cr-Mo10.1016/0142-9612(96)85766-8 ↗
72. Chemical modification of metallic implant surfaces with biofunctional proteins (Part 1). Molecular structure and biological activity of a modified NiTi alloy surface10.4012/dmj.14.185 ↗
73. Chemical modification of titanium surfaces for covalent attachment of biological molecules
74. Chemical and biological functionalization of titanium for dental implants10.1039/b715355b ↗
75. Wet-Chemical deposition of functional coatings for bone implantology10.1002/mabi.201000142 ↗
76. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule10.1038/309030a0 ↗
77. Biomimetic materials for tissue engineering10.1016/S0142-9612(03)00339-9 ↗
78. Biochemical modification of titanium surfaces: Peptides and ECM proteins10.22203/eCM.v012a01 ↗
79. In vivo effects of RGD-coated titanium implants inserted in two bone-gap models10.1002/jbm.a.30301 ↗
80. Functionalization of dental implant surfaces using adhesion molecules10.1002/jbm.b.30183 ↗
81. Biomimetic coatings functionalized with adhesion peptides for dental implants10.1023/A:1012807621414 ↗
82. An RGD spacing of 440 nm is sufficient for integrin alpha V beta 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation10.1083/jcb.114.5.1089 ↗
83. Extracellular matrix cell adhesion peptides: Functional applications in orthopedic materials10.1089/107632700320720 ↗
84. Biomimeticity in tissue engineering scaffolds through synthetic peptide modifications Altering chemistry for enhanced biological response
85. Growth factors in bone10.1007/s002640050290 ↗
86. Bone formation at rhBMP-2-coated titanium implants in the rat ectopic model10.1111/j.1600-051X.2007.01064.x ↗
87. Transforming growth factor-beta1 release from a porous electrostatic spray deposition-derived calcium phosphate coating10.1089/ten.2006.12.2449 ↗
88. In vitro responses to electrosprayed alkaline phosphatase/calcium phosphate composite coatings10.1016/j.actbio.2009.03.019 ↗
89. Osteoblast adhesion on biomaterials10.1016/S0142-9612(99)00242-2 ↗
90. Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies10.1016/S0142-9612(03)00360-0 ↗
91. Biological performance of biomimetic calcium phosphate coating of titanium implants in the dog mandible10.1002/jbm.a.10363 ↗
92. Collagen-hydroxyapatite composites for hard tissue repair10.22203/eCM.v011a06 ↗
93. The osteogenic effect of electrosprayed nanoscale collagen/calcium phosphate coatings on titanium10.1016/j.biomaterials.2009.11.114 ↗
94. Transforming growth factor beta1 immobilized adsorptively on Ti6Al4V and collagen type I coated Ti6Al4V maintains its biological activity10.1016/S0142-9612(03)00068-1 ↗
95. Use of bone morphogenetic protein 2 on ectopic porous coated implants in the rat
96. Ectopic bone formation by composites of BMP and metal implants in rats10.3109/17453679608997765 ↗
97. Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity10.1089/107632704322791745 ↗
98. Delivery mode and efficacy of BMP-2 in association with implants
99. Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity10.1089/107632704322791745 ↗
100. Delivery systems for BMPs: Factors contributing to protein retention at an application site10.2106/00004623-200100002-00007 ↗