Passive Layers and Corrosion Resistance of Biomedical Ti-6Al-4V and β-Ti Alloys
Source abstract
Abstract
The high specific strength, good corrosion resistance, and great biocompatibility make titanium and its alloys the ideal materials for biomedical metallic implants. Ti-6Al-4V alloy is the most employed in practical biomedical applications because of the excellent combination of strength, fracture toughness, and corrosion resistance. However, recent studies have demonstrated some limits in biocompatibility due to the presence of toxic Al and V. Consequently, scientific literature has reported novel biomedical β-Ti alloys containing biocompatible β-stabilizers (such as Mo, Ta, and Zr) studying the possibility to obtain similar performances to the Ti-6Al-4V alloys. The aim of this review is to highlight the corrosion resistance of the passive layers on biomedical Ti-6Al-4V and β-type Ti alloys in the human body environment by reviewing relevant literature research contributions. The discussion is focused on all those factors that influence the performance of the passive layer at the surface of the alloy subjected to electrochemical corrosion, among which the alloy composition, the method selected to grow the oxide coating, and the physicochemical conditions of the body fluid are the most significant.
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Research context
OpenAlex topics: Titanium Alloys Microstructure and Properties · Hydrogen embrittlement and corrosion behaviors in metals · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Innovation Engineering, University of Salento, Via per Monteroni, 73100 Lecce, Italy
School of Materials Science and Engineering, Jiangsu University of Science and Technology, Mengxi Road 2#, Zhenjiang 212003, China
Department of Dental Materials and Prosthesis, School of Dentistry of RibeirãoPreto, University of São Paulo (USP), Ribeirão Preto 14040-904, Brazil
FIME-Centro de Investigación e Innovación en Ingeniería Aeronáutica (CIIIA), Universidad Autonoma de Nuevo Leon, Av. Universidad s/n, Ciudad Universitaria, San Nicolás de los Garza 66455, Mexico
References (100+)
Show source-provided references
1. Progression of Bio-Tribocorrosion in Implant Dentistry10.3389/fmech.2020.00001 ↗
2. Synergistic interactions between corrosion and wear at titanium-based dental implant connections: A scoping review10.1111/jre.12469 ↗
3. Mehkri, S., Abishek, N.R., Sumanth, K.S., and Rekha, N. (2020). Study of the Tribocorrosion occurring at the implant and implant alloy Interface: Dental implant materials. Mater. Today Proc.10.1016/j.matpr.2020.08.550 ↗
4. Is there scientific evidence favoring the substitution of commercially pure titanium with titanium alloys for the manufacture of dental implants?10.1016/j.msec.2016.10.025 ↗
5. A Review on Biomedical Titanium Alloys: Recent Progress and Prospect10.1002/adem.201801215 ↗
6. Can degradation products released from dental implants affect peri-implant tissues?
7. What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review10.1111/clr.13305 ↗
8. Surface Modification of Titanium and Titanium Alloys: Technologies, Developments, and Future Interests10.1002/adem.201901258 ↗
9. Comparative analysis of corrosion resistance between beta titanium and Ti-6Al-4V alloys: A systematic review10.1016/j.jtemb.2020.126618 ↗
10. Influence of chemical composition on cell viability on titanium surfaces: A systematic review10.1016/j.prosdent.2020.02.001 ↗
11. Investigation of electrochemical corrosion behavior of additive manufactured Ti–6Al–4V alloy for medical implants in different electrolytes10.1016/j.jallcom.2020.154620 ↗
12. Surface damage of dental implant systems and ions release after exposure to fluoride and hydrogen peroxide
13. A study of the potentials achieved during mechanical abrasion and the repassivation rate of titanium and Ti6Al4V in inorganic buffer solutions and bovine serum10.1016/j.electacta.2004.07.024 ↗
14. Triboelectrochemical techniques and interpretation methods in tribocorrosion: A comparative evaluation10.1016/j.triboint.2007.11.003 ↗
15. Trojan-Like Internalization of Anatase Titanium Dioxide Nanoparticles by Human Osteoblast10.1038/srep23615 ↗
16. Comparison of cellular uptake and inflammatory response via toll-like receptor 4 to lipopolysaccharide and titanium dioxide nanoparticles10.3390/ijms140713154 ↗
17. Effects of titanium dioxide nanoparticle aggregate size on gene expression10.3390/ijms11062383 ↗
18. Chen, L.-Y., Cui, Y.-W., and Zhang, L.-C. (2020). Recent Development in Beta Titanium Alloys for Biomedical Applications. Metals, 10.10.3390/met10091139 ↗
19. Preliminary study of microstructure, mechanical properties and corrosion resistance of antibacterial Ti-15Zr-xCu alloy for dental application10.1016/j.jmst.2020.03.003 ↗
20. Investigation on the corrosion behavior and biocompatibility of Ti-6Al-4V implant coated with HA/TiN dual layer for medical applications10.1016/j.surfcoat.2020.126044 ↗
21. Electrochemical and XPS studies of corrosion behavior of Ti–23Nb–0.7Ta–2Zr–O alloy in Ringer’s solution10.1016/j.matchemphys.2008.08.043 ↗
22. Effect of surface treatment on electrochemical behavior of CP Ti, Ti–6Al–4V and Ti–13Nb–13Zr alloys in simulated human body fluid10.1016/j.corsci.2005.06.003 ↗
23. Corrosion resistance and biocompatibility of Ti–Ta alloys for biomedical applications10.1016/j.msea.2005.03.032 ↗
24. Fabrication of dental implants by the additive manufacturing method: A systematic review10.1016/j.prosdent.2019.01.018 ↗
25. Simultaneous improvement of corrosion resistance and bioactivity of a titanium alloy via wet and dry plasma treatments10.1016/j.jallcom.2020.156840 ↗
26. Evaluation of microstructure variation of TC11 alloy after electroshocking treatment10.1016/j.jmrt.2019.12.076 ↗
27. Pérez, D.A.G., Jorge Junior, A.M., Roche, V., Lepretre, J.C., Afonso, C.R.M., Travessa, D.N., Asato, G.H., Bolfarini, C., and Botta, W.J. (2020). Severe plastic deformation and different surface treatments on the biocompatible Ti13Nb13Zr and Ti35Nb7Zr5Ta alloys: Microstructural and phase evolutions, mechanical properties, and bioactivity analysis. J. Alloys Compd., 812.10.1016/j.jallcom.2019.152116 ↗
28. Structural and phase changes under electropulse treatment of fatigue-loaded titanium alloy VT1-010.1016/j.jmrt.2018.09.008 ↗
29. Improved bone-forming functionality on diameter-controlled TiO2 nanotube surface10.1016/j.actbio.2009.05.008 ↗
30. Corrosion fatigue of biomedical metallic alloys: Mechanisms and mitigation10.1016/j.actbio.2011.09.012 ↗
31. Bio-corrosion behaviour of oxygen diffusion layer on Ti-6Al-4V during tribocorrosion10.1016/j.corsci.2017.08.031 ↗
32. Lutjering, G., and Williams, C.J. (2007). Titanium, Springer. [2nd ed.].
33. Influence of Material Microstructures in Micromilling of Ti6Al4V Alloy10.3390/ma6094268 ↗
34. Ti based biomaterials, the ultimate choice for orthopaedic implants—A review10.1016/j.pmatsci.2008.06.004 ↗
35. Biocompatibility of Advanced Manufactured Titanium Implants—A Review10.3390/ma7128168 ↗
36. Wear and corrosion behaviour of Ti–13Nb–13Zr and Ti–6Al–4V alloys in simulated physiological solution10.1016/j.corsci.2010.11.014 ↗
37. Corrosion Behavior of Ti-6Al-4V with Different Thermomechanical Treatments and Microstructures10.5006/1.3452400 ↗
38. Composition and processing effects on the electrochemical characteristics of biomedical titanium alloys10.1016/j.corsci.2014.02.017 ↗
39. Corrosion characterization of titanium alloys by electrochemical techniques10.1016/j.electacta.2005.02.121 ↗
40. Passive film on orthopaedic TiAlV alloy formed in physiological solution investigated by X-ray photoelectron spectroscopy10.1016/S0142-9612(00)00145-9 ↗
41. The influence of niobium and vanadium on passivity of titanium-based implants in physiological solution10.1016/S0142-9612(03)00252-7 ↗
42. Voltammetric stability of anodic films on the Ti6Al4V alloy in chloride medium10.1016/j.electacta.2006.04.051 ↗
43. Aluminium in brain tissue in familial Alzheimer’s disease10.1016/j.jtemb.2016.12.001 ↗
44. Moretti, B., Pesce, V., MacCagnano, G., Vicenti, G., Lovreglio, P., Soleo, L., and Apostoli, P. (2012). Peripheral neuropathy after hip replacement failure: Is vanadium the culprit?. Lancet, 379.10.1016/S0140-6736(12)60273-6 ↗
45. Akahori, T., Niinomi, M., Fukui, H., Suzuki, A., Hattori, Y., and Niwa, S. (2004). Ti-2003, Science and Technology, Wiley-VCH.
46. Qazi, J.I., Tsakiris, V., Marquard, B., and Rack, H.J. (2004). Ti-2003, Science and Technology, WileyVCH.
47. Metastable Beta Titanium Alloys for Orthopedic Applications10.1002/adem.200500060 ↗
48. Corrosion behavior of β titanium alloys for biomedical applications10.1016/j.msec.2011.02.005 ↗
49. Pourbaix, M. (1974). Atlas of Electrochemical Equilibria in Aqueous Solution, National Association of Corrosion Engineers. [2nd ed.].10.1007/978-1-4684-1806-4_4 ↗
50. Surface modification techniques of titanium and titanium alloys for biomedical dental applications: A review10.1016/j.matpr.2020.06.163 ↗
51. The Microstructure and Capacitance Characterizations of Anodic Titanium Based Alloy Oxide Nanotube
52. Lazzari, L., and Pedeferri, M.P. (2018). Corrosion Science and Engineering, Springer Nature Switzerland AG.
53. Hussein, M.A., Kumar, M., Drew, R., and Al-Aqeeli, N. (2018). Electrochemical Corrosion and In Vitro Bioactivity of Nano-Grained Biomedical Ti-20Nb-13Zr Alloy in a Simulated Body Fluid. Materials, 11.10.3390/ma11010026 ↗
54. Ahn, J., and Michael, J.A. (2010). 13—Nuclear waste canister materials, corrosion behaviour and long-term performance in geological repository systems. Woodhead Publishing Series in Energy, Geological Repository Systems for Safe Disposal of Spent Nuclear Fuels and Radioactive Waste, Woodhead Publishing.10.1533/9781845699789 ↗
55. Nonalloyed titanium as a bioinert metal–A review
56. Corrosion of metal orthopaedic implants10.2106/00004623-199802000-00015 ↗
57. In vivo corrosion of modular hip prothesis components in mixed and similar metal combinations. The effect of crevice, stress, motion, and alloy coupling10.1002/jbm.820271210 ↗
58. Measurement and evaluation of galvanic corrosion between titanium/Ti6Al4V implants and dental alloys by electrochemical techniques and auger spectrometry10.1016/S0142-9612(98)00248-8 ↗
59. Noumbissi, S., Scarano, A., and Gupta, S. (2019). A Literature Review Study on Atomic Ions Dissolution of Titanium and Its Alloys in Implant Dentistry. Materials, 12.10.3390/ma12030368 ↗
60. Corrosion of biomedical implant materials10.1515/corrrev.2008.147 ↗
61. Biomedical implants: Corrosion and its prevention—A review10.2174/1877610801002010040 ↗
62. Eliaz, N. (2012). Medical implant corrosion: Electrochemistry at metallic biomaterial surfaces. Degradation of Implant Materials, Springer. Chapter 1.10.1007/978-1-4614-3942-4_1 ↗
63. Eliaz, N. (2012). Degradation of titanium and its alloys. Degradation of Implant Materials, Springer. Chapter 2.10.1007/978-1-4614-3942-4 ↗
64. Eliaz, N. (2012). Biodegradable metals. Degradation of Implant Materials, Springer. Chapter 5.10.1007/978-1-4614-3942-4 ↗
65. Corrosion behavior of metallic materials in biomedical applications. I. Ti and its alloys10.1515/corrrev-2014-0007 ↗
66. Eliaz, N. (2019). Corrosion of Metallic Biomaterials: A Review. Materials, 12.10.3390/ma12030407 ↗
67. Photoexcited formation of bone apatite-like coatings on micro-arc oxidazed titanium10.1002/jbm.a.30177 ↗
68. Landolt, D. (2007). Corrosion and Surface Science, CRC Press Taylor and Francis Group.
69. Formation of ionic space charge layers in oxide films on valve metals10.1016/0013-4686(94)E0046-3 ↗
70. An Anodized Titanium/Sol-Gel Composite Coating with Self-Healable Superhydrophobic and Oleophobic Property
71. Electrochemical properties, chemical composition and thickness of passive film formed on novel Ti–20Nb–10Zr–5Ta alloy10.1016/j.electacta.2013.03.086 ↗
72. Chapter seven-Anodization of titanium alloys for biomedical applications
73. Anodic oxidation of titanium and TA6V alloy in chromic media. An electrochemical approach10.1016/S0013-4686(99)00283-2 ↗
74. Progress in TiO2 nanotube coatings for biomedical applications: A review10.1039/C8TB00149A ↗
75. Lin, N., Li, D., Zou, J., Xie, R., Wang, Z., and Tang, B. (2018). Surface Texture-Based Surface Treatments on Ti6Al4V Titanium Alloys for Tribological and Biological Applications: A Mini Review. Materials, 11.10.3390/ma11040487 ↗
76. Michalska-Domańska, M., Łazińska, M., Łukasiewicz, J., Mol, J.M.C., and Durejko, T. (2020). Self-Organized Anodic Oxides on Titanium Alloys Prepared from Glycol- and Glycerol-Based Electrolytes. Materials, 13.10.3390/ma13214743 ↗
77. Local drug delivery to the bone by drug-releasing implants: Perspectives of nano-engineered titania nanotube arrays10.4155/tde.12.66 ↗
78. Characterization of the morphology, structure and wettability of phase dependent lamellar and nanotube oxides on anodized Ti-10Nb alloy10.1016/j.apsusc.2018.04.079 ↗
79. Characterization and photocatalytic properties of nanoporous titanium dioxide layer fabricated on pure titanium substrates by the anodic oxidation process10.1016/j.ceramint.2013.07.046 ↗
80. Electrochemical surface engineering of titanium-based alloys for biomedical application10.1016/j.electacta.2018.03.180 ↗
81. A Review on TiO2 Nanotubes: Influence of Anodization Parameters, Formation Mechanism, Properties, Corrosion Behavior, and Biomedical Applications10.1007/s40735-015-0024-x ↗
82. TiO2 nanotubes: Self-organized electrochemical formation, properties and applications10.1016/j.cossms.2007.08.004 ↗
83. A study on influence of anodization on the morphology of titania nanotubes over Ti6Al4V alloy in correlation to hard tissue engineering application10.1016/j.matchemphys.2020.123457 ↗
84. Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?10.1016/j.ceramint.2020.09.177 ↗
85. Reduced adhesion of macrophages on anodized titanium with select nanotube surface features
86. Hydroxyapatite growth on anodic TiO2 nanotubes10.1002/jbm.a.30677 ↗
87. The diameter of anodic TiO2 nanotubes affects bone formation and correlates with the bone morphogenetic protein-2 expression in vivo10.1111/j.1600-0501.2010.02139.x ↗
88. Recent progress in inorganic and composite coatings with bactericidal capability for orthopaedic applications10.1016/j.nano.2010.10.005 ↗
89. Swain, S., Misra, R.D.K., You, C.K., and Rautray, T.R. (2020). TiO2 nanotubes synthesised on Ti-6Al-4V ELI exhibits enhanced osteogenic activity: A potential next-generation material to be used as medical implants. Mater. Technol.10.1080/10667857.2020.1760510 ↗
90. A review of the application of anodization for the fabrication of nanotubes on metal implant surfaces
91. Anodic oxide nanotube layers on Ti–Ta alloys: Substrate composition, microstructure and self-organization on two-size scales10.1016/j.corsci.2008.11.011 ↗
92. Effect of porosity on mechanical and electrochemical properties of Ti-6Al-4V alloy10.1016/j.electacta.2020.135858 ↗
93. The electrochemical behaviour of Ti–13Nb–13Zr alloy in various solutions10.1002/maco.200804148 ↗
94. Mechanical and corrosion behaviour of a Ti–Al–Nb alloy after deformation at elevated temperatures10.1002/maco.200805003 ↗
95. Study of Ti–6Al–4V alloy spectral emissivity characteristics during thermal oxidation process10.1016/j.ijheatmasstransfer.2016.05.069 ↗
96. Thermal oxidation of titanium: Evaluation of corrosion resistance as a function of cooling rate10.1016/j.matchemphys.2012.12.020 ↗
97. Surface modification of titanium, titanium alloys, and related materials for biomedical applications10.1016/j.mser.2004.11.001 ↗
98. Ma, K., Zhang, R., Sun, J., and Liu, C. (2020). Oxidation Mechanism of Biomedical Titanium Alloy Surface and Experiment. Int. J. Corros., 1678615.10.1155/2020/1678615 ↗
99. Enhanced osteogenic activity and bacteriostatic effect of TiO2 coatings via hydrogen ion implantation10.1016/j.matlet.2019.06.042 ↗
100. Improved biological performance of Ti implants due to surface modification by micro-arc oxidation10.1016/j.biomaterials.2003.09.048 ↗