journal article·2025Open access

Intrusion Detection in Internet of Medical Things Using Digital Twins—A Review

Tony Thomas, Ravi Prakash, Soumya Pal

Computers, Materials & Continua· Volume 84· Issue 3

Abstract

The Internet of Medical Things (IoMT) is transforming healthcare by enabling real-time data collection, analysis, and personalized treatment through interconnected devices such as sensors and wearables. The integration of Digital Twins (DTs), the virtual replicas of physical components and processes, has also been found to be a game changer for the ever-evolving IoMT. However, these advancements in the healthcare domain come with significant cybersecurity challenges, exposing it to malicious attacks and several security threats. Intrusion Detection Systems (IDSs) serve as a critical defense mechanism, yet traditional IDS approaches often struggle with the complexity and scale of IoMT networks. With this context, this paper follows a systematic approach to analyze the existing literature and highlight the current trends and challenges related to IDS in the IoMT domain. We leveraged techniques like bibliographic and keyword analysis to collect 832 research works published from 2007 to 2025, aligned with the theme “Digital Twins and IDS in IoMT.” It was found that by simulating device behaviours and network interactions in IoMT, DTs not only provide a proactive platform for early threat detection, but also offer a scalable and adaptive approach to mitigating evolving security threats in IoMT. Overall, this review provides a closer look into the role of IDS and DT in securing IoMT systems and sheds light on the possible research directions for developers and the research community.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Internet of Things and AI · Advanced Malware Detection Techniques · Network Security and Intrusion Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (100+)

Show source-provided references
1. Digital twins in Industry 4.0 cyber security
2. A review of Internet of Things (IoT) embedded sustainable supply chain for industry 4.0 requirements10.1016/j.cie.2018.11.030 ↗
3. Digital twin in industry: state-of-the-Art10.1109/TII.2018.2873186 ↗
4. Digital twin: a comprehensive survey of security threats10.1109/COMST.2022.3171465 ↗
5. IoT-Enabled plant monitoring system with power optimization and secure authentication
6. Internet of things (IoT), applications and challenges: a comprehensive review10.1007/s11277-020-07446-4 ↗
7. Design of multipath transmission control for information-centric Internet of Things: a distributed stochastic optimization framework10.1109/JIOT.2019.2929263 ↗
8. Kamath · 2020 Global Internet of Things Summit (GIoTS) · 2020 Jun 3–5 · 1
9. TON_IoT telemetry dataset: a new generation dataset of IoT and IIoT for data-driven intrusion detection systems10.1109/ACCESS.2020.3022862 ↗
10. Meta-IDS: meta-learning based smart intrusion detection system for internet of medical things (IoMT) network10.1109/JIOT.2024.3387294 ↗
11. A security framework in digital twins for cloud-based industrial control systems: intrusion detection and mitigation
12. Digital twin-based intrusion detection for industrial control systems
13. Application of IoT-aided simulation to manufacturing systems in cyber-physical system10.3390/machines7010002 ↗
14. Khujamatov · IoT, IIoT, and cyber-physical systems integration. In: Emergence of cyber physical system and IoT in smart automation and robotics: computer engineering in automation · 2021 · 31
15. Cyber-physical systems architectures for industrial internet of things applications in Industry 4.0: a literature review10.1016/j.jmsy.2020.11.017 ↗
16. Design of a smart factory based on cyber-physical systems and Internet of Things towards Industry 4.010.3390/app13042156 ↗
17. Mitra · Next generation healthcare informatics · 2022 · 12110.1007/978-981-19-2416-3_8 ↗
18. Internet of medical things (IoMT): overview, emerging technologies, and case studies10.1080/02564602.2021.1927863 ↗
19. Internet of Things: device capabilities, architectures, protocols, and smart applications in healthcare domain10.1109/JIOT.2022.3228795 ↗
20. Federated learning for privacy preservation in smart healthcare systems: a comprehensive survey10.1109/JBHI.2022.3181823 ↗
21. Digital twins in healthcare: an architectural proposal and its application in a social distancing case study10.1109/JBHI.2022.3205506 ↗
22. Recent advances in the internet-of-medical-things (IoMT) systems security10.1109/JIOT.2020.3045653 ↗
23. IoMT-based smart healthcare of elderly people using deep extreme learning machine
24. Metaheuristic-based hyperparameter optimization for multi-disease detection and diagnosis in machine learning10.1007/s11761-023-00382-8 ↗
25. A healthcare monitoring system for the diagnosis of heart disease in the IoMT cloud environment using MSSO-ANFIS10.1109/ACCESS.2020.3006424 ↗
26. Applications of digital twin across industries: a review10.3390/app12115727 ↗
27. Interactive digital twins framework for asset management through internet
28. The place and role of digital twin in supply chain management
29. Digital twin-driven smart supply chain10.1007/s42524-021-0186-9 ↗
30. Overview on digital twin for autonomous electrical vehicles propulsion drive system10.3390/su14020601 ↗
31. Introducing digital twins to agriculture10.1016/j.compag.2020.105942 ↗
32. Intrusion detection in digital twins for industrial control systems
33. Towards secure AI-driven industrial metaverse with NFT digital twins
34. A systematic literature review of digital twin research for healthcare systems: research trends, gaps, and realization challenges10.1109/ACCESS.2023.3349379 ↗
35. A comprehensive and systematic literature review on intrusion detection systems in the internet of medical things: current status, challenges, and opportunities10.1007/s10462-024-11101-w ↗
36. Digital twin for drug discovery and development-the virtual liver10.1007/s41745-020-00185-2 ↗
37. Drug development digital twins for drug discovery, testing and repurposing: a schema for requirements and development10.3389/fsysb.2022.928387 ↗
38. Unlocking the future of drug development: generative AI, Digital Twins, and Beyond10.3390/biomedinformatics4020079 ↗
39. Virtual patients, digital twins and causal disease models: paving the ground for in silico clinical trials10.1016/j.drudis.2023.103605 ↗
40. Digital-Twin-Enabled IoMT system for surgical simulation using rAC-GAN10.1109/JIOT.2022.3176300 ↗
41. Review on approaches of federated modeling in anomaly-based intrusion detection for IoT devices10.1109/ACCESS.2024.3369915 ↗
42. Security and privacy of internet of medical things: a contemporary review in the age of surveillance, botnets, and adversarial ML10.1016/j.jnca.2022.103332 ↗
43. Hromada · Research anthology on convergence of blockchain, internet of things, and security · 2023 · 67
44. Insights into Internet of Medical Things (IoMT): data fusion, security issues and potential solutions10.1016/j.inffus.2023.102060 ↗
45. Machine learning and deep learning methods for intrusion detection systems in IoMT: a survey
46. IoMT-TrafficData: dataset and tools for benchmarking intrusion detection in internet of medical things10.1109/ACCESS.2024.3437214 ↗
47. ELNIDS: ensemble learning based network intrusion detection system for RPL based Internet of Things
48. Lightweight Intrusion Detection System (L-IDS) for the Internet of Things
49. Intrusion detection and prevention in Industrial IoT: a technological survey
50. An IoT/IoMT security testbed for anomaly-based intrusion detection systems
51. Artificial intelligence for IoMT security: a review of intrusion detection systems, attacks, datasets and Cloud-Fog-Edge architectures10.1016/j.iot.2023.100887 ↗
52. VOSviewer version 1.6.20 [Internet]. [cited 2024 Nov 28]. Available from: https://app.vosviewer.com/.
53. Digital twin networks: a survey10.1109/JIOT.2021.3079510 ↗
54. Hierarchical federated learning based anomaly detection using digital twins for smart healthcare
55. An intrusion detection mechanism for secured IoMT framework based on swarm-neural network10.1109/JBHI.2021.3101686 ↗
56. Internet of things: a general overview between architectures, protocols and applications10.3390/info12020087 ↗
57. Middleware for the Internet of Things: a survey on requirements, enabling technologies, and solutions10.1016/j.sysarc.2021.102098 ↗
58. Discovering hazards in IoT architectures: a safety analysis approach for medical use cases10.1109/ACCESS.2023.3280414 ↗
59. BEdgeHealth: a decentralized architecture for edge-based IoMT networks using blockchain10.1109/JIOT.2021.3058953 ↗
60. Digital Twin: benefits, use cases, challenges, and opportunities10.1016/j.dajour.2023.100165 ↗
61. Digital twin in the IoT context: a survey on technical features, scenarios, and architectural models10.1109/JPROC.2020.2998530 ↗
62. Digital twin for intelligent context-aware IoT healthcare systems10.1109/JIOT.2021.3051158 ↗
63. makeTwin: a reference architecture for digital twin software platform10.1016/j.cja.2023.05.002 ↗
64. Digital twin as a proxy for industrial cyber-physical systems
65. Construction of a digital twin framework using free and open-source software programs10.1109/MIC.2021.3051798 ↗
66. Lazzari L, Farias K. Uncovering the hidden potential of event-driven architecture: a research agenda. arXiv:2308.05270. 2023.
67. Architecture of a human-digital twin as common interface for operator 4.0 applications10.1016/j.procir.2021.11.077 ↗
68. A proposal to evolving towards digital twins in healthcare
69. Real-world anomaly detection by using digital twin systems and weakly supervised learning10.1109/TII.2020.3019788 ↗
70. Integrating digital twins with AI for real-time intrusion detection in smart infrastructure networks
71. Open process automation-and digital twin-based performance monitoring of a process manufacturing system10.1109/ACCESS.2022.3179982 ↗
72. Digital twin as a service (DTaaS) in Industry 4.0: an architecture reference model10.1016/j.aei.2020.101225 ↗
73. Smart monitoring solution for dengue infection control: a digital twin-inspired approach10.1016/j.cmpb.2024.108459 ↗
74. An anomaly-based intrusion detection system for internet of medical things networks10.3390/electronics10212562 ↗
75. DT-IoMT: a digital twin reference model for secure internet of medical things
76. Security risk assessment of metaverse based healthcare systems based on common vulnerabilities and exposures (CVE)
77. Poisoning attacks in federated edge learning for digital twin 6G-enabled IoTs: an anticipatory study
78. A scalable digital twin framework based on a novel adaptive ensemble surrogate model10.1115/1.4056077 ↗
79. Deep-learning-enhanced digital twinning of complex composite structures and real-time mechanical interaction10.1016/j.compscitech.2023.110139 ↗
80. Huang Z, Zhang N, Shen J, Diamantopoulos G, Hua Z, Tziritas N, et al. Distributed simulation for digital twins of large-scale real-world DiffServ-based networks. arXiv:2405.20815. 2024.10.1007/978-3-031-69583-4_18 ↗
81. Addressing the scalability of network digital twins: a network sampling approach
82. IoT medical device risks: data security, privacy, confidentiality and compliance with HIPAA and COBIT 201910.4102/sajbm.v56i1.4796 ↗
83. Anatomy of threats to the internet of things10.1109/COMST.2018.2874978 ↗
84. Franklin · Security analysis of first responder mobile and wearable devices · 202010.6028/NIST.IR.8196 ↗
85. Security in IoMT communications: a survey10.3390/s20174828 ↗
86. A systematic review on security vulnerabilities to preveny types of attacks in iomt
87. CICIoMT2024: a benchmark dataset for multi-protocol security assessment in IoMT10.1016/j.iot.2024.101351 ↗
88. Areia J, Bispo IA, Santos L, Costa RL. IoMT-TrafficData: a dataset for benchmarking intrusion detection in IoMT. Zenodo. 2023 [Dataset]. doi:10.5281/zenodo.8116338.10.1109/ACCESS.2024.3437214 ↗
89. ECU-IoHT: a dataset for analyzing cyberattacks in Internet of Health Things10.1016/j.adhoc.2021.102621 ↗
90. Intrusion detection system for healthcare systems using medical and network data: a comparison study10.1109/ACCESS.2020.3000421 ↗
91. Zolanvari M, Teixeira MA, Gupta L, Khan KM, Jain R. WUSTL-IIOT-2021 dataset for IIoT cybersecurity research. 2021 [Internet]. [cited 2024 Nov 28]. Available from: http://www.cse.wustl.edu/∼jain/iiot2/index.html.
92. Ferrag MA, Friha O, Hamouda D, Maglaras L, Janicke H. Edge-IIoTset: a new comprehensive realistic cyber security dataset of IoT and IIoT applications: centralized and federated learning. IEEE Dataport. 2022 [Dataset]. doi:10.21227/mbc1-1h68.10.36227/techrxiv.18857336.v1 ↗
93. Toward generating a new intrusion detection dataset and intrusion traffic characterization
94. A scheme for generating a dataset for anomalous activity detection in IoT networks
95. Meidan Y, Bohadana M, Mathov Y, Mirsky Y, Breitenbacher D, Shabtai A. UCI Machine Learning Repository. 2018 [Dataset]. doi:10.24432/C5RC8J.
96. UNSW-NB15: a comprehensive data set for network intrusion detection systems (UNSW-NB15 network data set)
97. A detailed analysis of the KDD CUP 99 data set
98. FedMADE: robust federated learning for intrusion detection in iot networks using a dynamic aggregation method
99. Pope · Security and privacy in smart environments · 2024 · 98
100. Federated learning-based intrusion detection system for the internet of things using unsupervised and supervised deep learning models10.1016/j.csa.2024.100068 ↗