Gemini Dressing with Both Super-hydrophilicity and -hydrophobicity Pursuing Isolation of Blood Cells for Hemostasis and Wound Healing

Achieving efficient hemostasis and wound management is vital to preserve life and restore health in case of extensive hemorrhagic skin damage. Here, we develop a filter pump-like hierarchical porous-structure (HPS) dressing based on a non-woven substrate, konjac glucomannan (KGM) aerogel, and bi-functional microporous starch (BMS). The KGM aerogel intercalates into the non-woven network structure, forming a hydrophilic frame to stimulate the plasma permeation toward the interior in synergy with the hydrophilic pores of the BMS. The BMS surface forms a hydrophobic matrix that fills the spaces of the KGM hydrophilic frame, contributing to the isolation and aggregation of blood cells on the surface of the HPS dressing to establish rapid hemostasis. Animal model experiments suggest reliable HPS dressing hemostatic capacity, as it is able to stop ear artery and liver bleeding within 97.6 ± 15.2 s and 67.8 ± 5.4 s, respectively. Furthermore, the dressings exhibit antibacterial properties and enabled wound healing within 2 weeks. In vitro hemolysis and cytotoxicity tests also confirm the biocompatibility of HPS dressings. This novel “two-in-one” hemostatic dressing facilitates tissue repair of bleeding wounds over the entire recovery period, thereby providing a convenient strategy for wound management. A Gemini HPS dressing for both hemostasis and wound healing was proposed using amphiphilic hierarchical-porous structures to isolate and aggregate blood cells to promote hemostasis, and alloy nanoparticles to inhibit bacterial proliferation to accelerate wound healing.