Leveraging Two‐Dimensionality Matters in Cancer Combination Therapy: Synthetic Methods for Production, Surface Functionalization, and Immunomodulation

2D materials are covalently bonded atoms arranged in a limited number of atomic layers, confined from growing in additional dimensions and expanding primarily laterally and vertically. The development of 2D materials has progressed significantly, evolving from simple monatomic sheets to diverse multielemental systems, with graphene being the most studied due to its remarkable properties. This review examines synthesis and functionalization methods, highlighting innovative fabrication strategies enabled by patented technologies. It explores the preclinical applications of 2D materials in drug delivery and cancer immunotherapy, emphasizing their potential to enhance therapeutic precision and efficacy. Key challenges, including scalability, biocompatibility, and regulatory issues, are discussed as barriers to clinical application. The review also outlines future directions to enhance the performance and safety of 2D material‐based biomedical platforms.