journal article·2026-05

Macromolecule‐Mediated Exfoliation of Two‐Dimensional Materials: Mechanisms, Advancements, and Perspectives

Jiheng Yang, Kexin Zhang, Kai Wang, Xiaoling Yang, Peng Yang, Hao Ren

ChemNanoMat· Volume 12· Issue 5
Publisher page

Abstract

The scalable production of high‐quality two‐dimensional materials (2DMs) remains challenging due to the limited efficiency, poor controllability, and environmental concerns associated with conventional exfoliation methods. Macromolecule‐mediated exfoliation (MME) has emerged as an efficient and sustainable strategy for the preparation of 2DMs. By exploiting controlled force transmission and interfacial interactions, macromolecules enable effective layer separation while stabilizing exfoliated nanosheets and introducing surface functionality. This review summarizes recent progress in mechanically assisted exfoliation of 2DMs using natural and synthetic macromolecules, highlights underlying exfoliation mechanisms and macromolecular design principles, and discusses current challenges and future opportunities in this rapidly evolving field.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Polymer Surface Interaction Studies · Graphene research and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University Xi’an China

Xi’an Key Laboratory of Polymeric Soft Matter School of Chemistry and Chemical Engineering Shaanxi Normal University Xi’an China

International Joint Research Center on Functional Fiber and Soft Smart Textile School of Chemistry and Chemical Engineering Shaanxi Normal University Xi’an China

Funding

National Natural Science Foundation of China · National Science Foundation for Distinguished Young Scholars · Fundamental Research Fund for the Central Universities

References (100+)

Show source-provided references
1. 10.3390/s1602022310.3390/s16020223 ↗
2. 10.1021/ar500274q10.1021/ar500274q ↗
3. 10.1038/nnano.2012.19310.1038/nnano.2012.193 ↗
4. 10.1038/ncomms555410.1038/ncomms5554 ↗
5. 10.1016/j.scib.2019.09.02110.1016/j.scib.2019.09.021 ↗
6. 10.1002/lpor.20180032710.1002/lpor.201800327 ↗
7. 10.1021/acsenergylett.7b0116910.1021/acsenergylett.7b01169 ↗
8. 10.1016/j.bios.2016.03.06810.1016/j.bios.2016.03.068 ↗
9. 10.1016/j.bioactmat.2020.06.01210.1016/j.bioactmat.2020.06.012 ↗
10. 10.1002/adma.20150630610.1002/adma.201506306 ↗
11. 10.1016/j.jechem.2017.10.03310.1016/j.jechem.2017.10.033 ↗
12. 10.1126/science.110289610.1126/science.1102896 ↗
13. 10.1038/nmat184910.1038/nmat1849 ↗
14. 10.1016/j.commatsci.2011.12.02910.1016/j.commatsci.2011.12.029 ↗
15. 10.1021/nn203879f10.1021/nn203879f ↗
16. 10.1126/science.115799610.1126/science.1157996 ↗
17. 10.1016/j.ssc.2008.02.02410.1016/j.ssc.2008.02.024 ↗
18. 10.1021/acsami.5c0162010.1021/acsami.5c01620 ↗
19. 10.1016/j.saa.2022.12170110.1016/j.saa.2022.121701 ↗
20. 10.1021/acsnano.9b0639410.1021/acsnano.9b06394 ↗
21. 10.1038/nnano.2008.21510.1038/nnano.2008.215 ↗
22. 10.1002/adfm.20070079710.1002/adfm.200700797 ↗
23. 10.1126/science.117124510.1126/science.1171245 ↗
24. 10.1002/adfm.20090164010.1002/adfm.200901640 ↗
25. 10.1016/j.ssc.2009.09.01810.1016/j.ssc.2009.09.018 ↗
26. 10.1039/b923656b10.1039/b923656b ↗
27. 10.1002/anie.20100180610.1002/anie.201001806 ↗
28. 10.1007/s10570-014-0264-910.1007/s10570-014-0264-9 ↗
29. 10.1038/nmat394410.1038/nmat3944 ↗
30. 10.1016/j.carbon.2015.12.03010.1016/j.carbon.2015.12.030 ↗
31. 10.1021/acsnano.8b0632110.1021/acsnano.8b06321 ↗
32. 10.1016/j.carbon.2019.10.06310.1016/j.carbon.2019.10.063 ↗
33. 10.1007/s12274-022-5123-710.1007/s12274-022-5123-7 ↗
34. 10.1016/j.coco.2024.10209410.1016/j.coco.2024.102094 ↗
35. 10.1016/j.mtnano.2025.10060410.1016/j.mtnano.2025.100604 ↗
36. 10.1038/s41563-021-01029-910.1038/s41563-021-01029-9 ↗
37. 10.1021/acs.chemrev.8b0005610.1021/acs.chemrev.8b00056 ↗
38. 10.1021/nn203700w10.1021/nn203700w ↗
39. 10.1021/nn201207c10.1021/nn201207c ↗
40. 10.1002/cvde.20130005110.1002/cvde.201300051 ↗
41. 10.1007/s10384-014-0325-510.1007/s10384-014-0325-5 ↗
42. 10.3389/fchem.2018.0057210.3389/fchem.2018.00572 ↗
43. 10.1002/aoc.595010.1002/aoc.5950 ↗
44. 10.1002/chem.20190071610.1002/chem.201900716 ↗
45. 10.1002/adma.20150448410.1002/adma.201504484 ↗
46. 10.1038/nnano.2015.4010.1038/nnano.2015.40 ↗
47. 10.1002/anie.20170638910.1002/anie.201706389 ↗
48. 10.1002/adfm.20150221410.1002/adfm.201502214 ↗
49. 10.1038/ncomms407110.1038/ncomms4071 ↗
50. 10.1021/ja412650s10.1021/ja412650s ↗
51. 10.1021/nn405148t10.1021/nn405148t ↗
52. 10.1002/adfm.20180197210.1002/adfm.201801972 ↗
53. 10.1016/j.matdes.2017.04.08310.1016/j.matdes.2017.04.083 ↗
54. 10.1021/jp302365w10.1021/jp302365w ↗
55. 10.1016/j.eml.2017.01.00810.1016/j.eml.2017.01.008 ↗
56. 10.1021/acsami.5b0561510.1021/acsami.5b05615 ↗
57. 10.1002/adma.20230325510.1002/adma.202303255 ↗
58. 10.1002/adma.20150325510.1002/adma.201503255 ↗
59. 10.3390/mi1501008210.3390/mi15010082 ↗
60. 10.1021/acs.chemrev.3c0030210.1021/acs.chemrev.3c00302 ↗
61. 10.1007/s10570-022-04857-310.1007/s10570-022-04857-3 ↗
62. 10.1021/acsanm.4c0207110.1021/acsanm.4c02071 ↗
63. Salting‐Out Effect Protected Ball‐Milling Exfoliation of Hexagonal Boron Nitride and the Scale Laws on the Thermal Conductivities of the Exfoliated Nanosheet Assembled Composite Films
64. 10.1021/acsanm.1c0269610.1021/acsanm.1c02696 ↗
65. 10.1021/jacs.5b0278010.1021/jacs.5b02780 ↗
66. 10.1021/acssuschemeng.2c0158110.1021/acssuschemeng.2c01581 ↗
67. 10.1016/j.cej.2023.14444510.1016/j.cej.2023.144445 ↗
68. 10.1002/adma.20231099910.1002/adma.202310999 ↗
69. 10.3390/polym1616227310.3390/polym16162273 ↗
70. 10.1021/acsnano.1c1109710.1021/acsnano.1c11097 ↗
71. 10.1021/acsami.8b0477710.1021/acsami.8b04777 ↗
72. 10.1016/j.mattod.2021.08.00910.1016/j.mattod.2021.08.009 ↗
73. 10.1039/C8GC01162A10.1039/C8GC01162A ↗
74. 10.1007/s10853-021-06403-110.1007/s10853-021-06403-1 ↗
75. 10.1016/j.giant.2024.10026410.1016/j.giant.2024.100264 ↗
76. 10.1021/acsanm.8b0078810.1021/acsanm.8b00788 ↗
77. 10.1002/adbi.20180010210.1002/adbi.201800102 ↗
78. 10.1039/C6RA13993K10.1039/C6RA13993K ↗
79. 10.1016/j.biomaterials.2010.10.03010.1016/j.biomaterials.2010.10.030 ↗
80. 10.1002/adma.20220685510.1002/adma.202206855 ↗
81. 10.1021/am505305g10.1021/am505305g ↗
82. 10.1016/j.jeurceramsoc.2025.11796210.1016/j.jeurceramsoc.2025.117962 ↗
83. 10.3390/polym1710133310.3390/polym17101333 ↗
84. 10.1016/j.ultsonch.2017.11.02810.1016/j.ultsonch.2017.11.028 ↗
85. 10.3390/molecules2722781010.3390/molecules27227810 ↗
86. 10.1038/s41467-022-35569-810.1038/s41467-022-35569-8 ↗
87. 10.1002/adfm.20252207310.1002/adfm.202522073 ↗
88. 10.1002/adma.20160469110.1002/adma.201604691 ↗
89. 10.1246/cl.18014410.1246/cl.180144 ↗
90. 10.1021/acsomega.2c0440910.1021/acsomega.2c04409 ↗
91. 10.1002/pc.2642410.1002/pc.26424 ↗
92. 10.1007/s10103-017-2422-410.1007/s10103-017-2422-4 ↗
93. 10.1002/adfm.20170162210.1002/adfm.201701622 ↗
94. 10.3390/biomedicines1012323810.3390/biomedicines10123238 ↗
95. 10.1098/rsos.20091110.1098/rsos.200911 ↗
96. 10.1021/acssuschemeng.8b0264410.1021/acssuschemeng.8b02644 ↗
97. 10.1039/C3RA45984E10.1039/C3RA45984E ↗
98. 10.1039/C7NR06807G10.1039/C7NR06807G ↗
99. 10.1016/j.colsurfb.2023.11359510.1016/j.colsurfb.2023.113595 ↗
100. 10.1016/j.microc.2025.11264710.1016/j.microc.2025.112647 ↗