Front Cover: Construction of FRET‐Based Off‐On Fluorescent Nanoprobes for Sensitive Detection of Intracellular Singlet Oxygen (ChemNanoMat 2/2020)

A novel Off-On type FRET-based fluorescent nanoprobe, mainly consisting of the energy-donating conjugated polymer poly(9,9-dioctylfluorenyl-2,7-diyl and energy-accepting 1O2 indicator 3-diphenylisobenzofuran, was prepared for monitoring intracellular 1O2 during photodynamic therapy. Under visible excitation or even NIR two-photon excitation, the initially non-fluorescent nanoprobe lit up in the presence of 1O2. This FRET-based strategy is very promising for construction of fluorescent nanoprobes for other reactive oxygen species (ROS). More information can be found in the Full Paper by Hong-shang Peng et al. on page 232 in Issue 2, 2020 (DOI: 10.1002/cnma.201900571).