Front Cover: Translating a Low‐Molecular‐Weight MRI Probe Sensitive to Amino Acid Neurotransmitters into a PAMAM Dendrimer Conjugate: The Impact of Conjugation (ChemNanoMat 12/2019)

Conjugates of a PAMAM dendrimer with neurotransmitter-sensitive MRI units showed a remarkable response towards amino acid neurotransmitters Glu, Gly or GABA. These nano-sized MRI contrast agents should exhibit improved biocompatibility, slower diffusion through the extracellular space and hence a prolonged interaction with neurotransmitters during neuronal activity compared to their monomeric analogues. Molecular imaging, more specifically functional MRI, can benefit greatly from the utilization of such multimeric and responsive probes for monitoring synaptic transmission. Image in part from Katestudio - stock.adobe.com. More information can be found in the Communication by Goran Angelovski and Đorđe Toljić on page 1456 in Issue 12, 2019 (DOI: 10.1002/cnma.201900552).