Cover Feature: Pep‐Lipid Cubosomes and Vesicles Compartmentalized by Micelles from Self‐Assembly of Multiple Neuroprotective Building Blocks Including a Large Peptide Hormone PACAP‐DHA (ChemNanoMat 11/2019)
Source abstract
Abstract
Compartmentalized liquid crystalline nanostructures embedding a class B GPCR ligand pituitary adenylate cyclase-activating polypeptide (PACAP), which is modified by an ω-3 polyunsaturated fatty acid DHA, are obtained in a two-fold approach by co-assembly of the lipidated peptide hormone with multiple neuroprotective compounds. The performed synchrotron small-angle X-ray scattering (BioSAXS) and cryo-TEM studies evidenced the formation of (i) intriguing compartmentalized vesicles enclosing nanopatterns of pep-lipid micelles and (ii) pep-lipid cubosomes of core-shell organizations. More information can be found in the Full Paper by Angelina Angelova et al. on page 1381 in Issue 11, 2019 (DOI: 10.1002/cnma.201900468).
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Lipid Membrane Structure and Behavior · Chemical Synthesis and Analysis
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Affiliations
Institut Galien Paris-Sud CNRS UMR 8612 Univ. Paris-Sud Université Paris-Saclay LabEx LERMIT 92290 Châtenay-Malabry France
Keylab “Electron and Optical Microscopy” Bavarian Polymerinstitute (BPI) University of Bayreuth 95440 Bayreuth Germany
Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research 21502 Geesthacht Germany
Institute of Physics ELI Beamlines Academy of Sciences of the Czech Republic Na Slovance 2 CZ-18221 Prague Czech Republic
References
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