Nanozymes of Ni_0.5Fe_0.5S₂ Mediated Synergetic Antitumor Treatment

Abstract How to establish a multi‐modality oncotherapy method on the basis of single matter mediated utilization of tumor endogenous substances is very promising for efficient antitumor treatment. In this work, we have designed a metallic Ni_0.5Fe_0.5S₂ nanosphere for synergetic chemodynamic/photodynamic/photothermal antitumor treatments. Under NIR excitation, a remarkable photothermal effect could be generated by Ni_0.5Fe_0.5S₂ for realizing the photothermal therapy. Meanwhile, Ni_0.5Fe_0.5S₂ could also trigger formation of reactive oxygen species (ROS) via transformation of tumor‐site oxygen for the further photodynamic therapy. Furthermore, peroxidase‐like property of Ni_0.5Fe_0.5S₂ favors the catalysis of endogenous H₂O₂ into hydroxyl radical to achieve a chemodynamic therapy. As a result, the on‐site tumor hyperthermia, tumor‐site oxygen and H₂O₂ conversion are worked for the antitumor action. On the merits of above synergistic effect, a better antitumor outcome was confirmed as compared with any single antitumor action, and complete removal of solid tumor under a relative lower temperature has been accomplished.