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journal article·2022-10Open access

Magnetic Relaxation and Modification of Thiol Groups on Co‐Mg Ferrite Nanoparticles for Theranostics

Hikaru Katayanagi, Naoki Sakai, Sota Hamada, Akihito Usui, Kota Aoki, Keita Kodama, Kentaro Nashimoto, Yoshiyuki Hosokai, Yuko Ichiyanagi

ChemNanoMat· Volume 8· Issue 10
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Abstract

Abstract Co1‐xMgxFe2O4 (x=0.0, 0.2, 0.4, 0.6, 0.8, 1.0) nanoparticles embedded in amorphous SiO2 with particle sizes of approximately 4.5 nm were prepared using an original wet chemical method. We performed spin‐echo magnetic resonance imaging measurements for Co1‐xMgxFe2O4 nanoparticles using a 0.3‐T MRI system. The particles exhibited a significant T2 shortening effect compared with that of agarose, depending on the composition. All particles exhibited effective relaxivity, R2, and a significant contrast was observed in the phantom image. Furthermore, thiol group was modified to enable particles to bind specifically to maleimide proteins. These particles are expected to be potential theranostic agents.
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Research context

Nanomaterials

OpenAlex topics: Advanced MRI Techniques and Applications · Characterization and Applications of Magnetic Nanoparticles · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Physics, Graduate School of Science and Engineering Yokohama National University 79-5 Tokiwadai, Hodogaya, Yokohama Kanagawa 240-8501 Japan

Graduate School of Medicine Tohoku University 2-1 Seoryo-cho, Aoba-ku, Sendai Miyagi 980-8575 Japan

Department of Radiological Sciences International University of Health and Welfare 2006-1 Kitakanemaru, Otawara Tochigi 324–8501 Japan

Graduate School of Science, Research Center for Thermal and Entropic Science Osaka University Osaka 560-0043 Japan

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