Source abstract
Abstract
Abstract Herein, we describe a new type of building block for nanoconstruction based on the composite of a boron cluster metal‐complex (metallacarborane) and therapeutic nucleic acid and their assembly into functional nanoparticles with EGFR oncogene silencing activity. In this direction, a method for oligofunctionalization of a metallacarborane, 3,3’‐cobalt‐bis(1,2‐dicarbollide)(−1) ion, and an automated method for synthesis of DNA‐oligonucleotides attached to the metallacarborane core is developed. The obtained building blocks forms nanoparticles with a “chrysanthemum‐like” topology that carry a slowly releasing antisense anti‐EGFR oligonucleotide silencing EGFR gene efficiently in vitro in a pancreatic carcinoma cell line PANC‐1.
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Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Boron Compounds in Chemistry · Nanocluster Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Medicinal Chemistry Institute of Medical Biology PAS Lodowa 106 92-232 Lodz Poland
The Bio-Med-Chem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences University of Lodz 90-237 Lodz Poland
Division of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies PAS Sienkiewicza 112 90-363 Lodz Poland
Department of Syntheses Institute of Inorganic Chemistry CAS Hlavní 1001 250 68 Rež Czech Republic
Independent Microscopy Team Centre for Polymer and Carbon Materials PAS M. Curie-Skłodowskiej 34 41-813 Zabrze Poland
Funding
Grantová Agentura České Republiky · Ministerstwo Edukacji i Nauki
References (28)
Show source-provided references
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