Highly Stable Nanostructured Magnetic Vesicles as Doxorubicin Carriers for Field‐assisted Therapies
Source abstract
Abstract
Abstract In this work, magnetic vesicles were produced using magnetite (Fe3O4) nanoparticles and 1‐methylimidazolium bis‐ (2‐ethylhexyl) phosphate (imim‐DEHP) as surfactant. Some of the vesicles were subsequently coated with chitosan to improve their stability and biocompatibility. A physicochemical characterization of the prepared systems was carried out using several techniques, which allowed verifying that the magnetic nanoparticles were successfully encapsulated. Finally, the vesicles were loaded with an antitumor drug (doxorubicin) by swelling in order to perform release studies. The Korsmeyer‐Peppas model was used to fit the doxorubicin (Dox) release profiles in the different vesicle systems, which displayed delayed release in every case. After 24 h, the Dox release percentages ranged between 43–53%. The prepared vesicles show not only excellent stability but also a good response to an external magnetic field, which makes them good candidates to be used in field‐assisted therapies, thus trying to improve therapeutic efficacy and avoiding possible adverse effects.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Magnetic Properties and Synthesis of Ferrites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Departamento de Química Universidad Nacional de Río Cuarto Córdoba Argentina
Instituto de desarrollo Agroindustrial y de la Salud (IDAS) Universidad Nacional de Río Cuarto Córdoba Argentina
Instituto de Física Enrique Gaviola (IFEG) CONICET, Ciudad Universitaria Córdoba Argentina
Facultad de Matemática, Astronomía, Física y Computación (FAMAF) Universidad Nacional de Córdoba, Ciudad Universitaria Córdoba Argentina
Laboratorio Químico de Materiales Magnéticos Aplicados a la Ingeniería (LaQuiMMAI) Facultad de Ingeniería – UBA, Instituto de Química Aplicada a la Ingeniería (IQAI-UBA) Buenos Aires Argentina
Instituto de Investigaciones en Físico-Química de Córdoba (INFIQC-CONICET) – Departamento de Química Orgánica Facultad de Ciencias Químicas Universidad Nacional de Córdoba, Ciudad Universitaria Córdoba Argentina
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