DataVXChemNanoMatPaper
journal article·2020-09

Cover Feature: Fabrication of Carboxymethyl Chitosan Nanoparticles to Deliver Paclitaxel for Melanoma Treatment (ChemNanoMat 9/2020)

Abolfazl Salehi Moghaddam, Hossein Ali Khonakdar, Einollah Sarikhani, Seyed Hassan Jafari, Azizeh Javadi, Mohammad Shamsi, Mohammad Amir Amirkhani, Samad Ahadian

ChemNanoMat· Volume 6· Issue 9
Publisher page
Source abstract

Abstract

Paclitaxel was encapsulated in chitosan nanoparticles using a microfluidic device and then was used as an anti-cancer drug to treat skin cancer. The device resulted in a uniform fabrication of nanoparticles with tunable physicochemical properties. The anticancer efficiency of the drug was shown in vitro and in animal models. The results revealed that the nanoparticle drugs increased the cellular uptake and cytotoxicity of cancer cells compared to control samples. In addition, the anti-tumor effect of drugs on mice with melanoma indicated potent inhibitory effect of nanoparticle drugs on the tumor growth. More information can be found in the Full Paper by Hossein Ali Khonakdar, Samad Ahadian et al.
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Research context

Nanomaterials

OpenAlex topics: Cancer Research and Treatment · Nanoparticle-Based Drug Delivery · Biological Research and Disease Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Chemical Engineering College of Engineering University of Tehran Tehran 11155-4593 Iran

Leibniz Institute of Polymer Research Dresden Hohe Straße 6 Dresden D-01069 Germany

Iran Polymer and Petrochemical Institute (IPPI) Tehran 14965-115 Iran

Department of Bioengineering University of California-Los Angeles Los Angeles CA 90095 USA

Department of Polymer Engineering and Color Technology Amirkabir University of Technology Tehran 15875-4413 Iran

Department of Chemical and Biomolecular Engineering North Carolina State University Raleigh-Durham NC 27695-7905 USA

Stem Cell and Regenerative Medicine Center of Excellence Tehran University of Medical Sciences Tehran 19379-57511 Iran

Terasaki Institute for Biomedical Innovation (TIBI) Los Angeles CA 90024 USA

References

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