The Choice of Nanoparticle Surface‐Coupled Fluorescent Dyes Impacts Cellular Interaction
Source abstract
Abstract
Abstract Fluorescently‐labelled nanoparticles show great promise for nanoparticle tracking and detection in biological or medical applications. However, these fluorescent molecules functionalized on the surface of the nanoparticles can impact the interaction of nanoparticles with biomolecules, cells, and subsequently influence their uptake. To explore the extent of these interactions, PEGylated gold nanoparticles were functionalized with six structurally different fluorescent dyes to demonstrate that the presence of the dye alters nanoparticle behavior, in particular interactions with bovine serum albumin, which consequently influenced their cellular uptake.
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Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Gold and Silver Nanoparticles Synthesis and Applications · Protein Interaction Studies and Fluorescence Analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Adolphe Merkle Institute University of Fribourg Ch. des Verdiers 4 Fribourg CH-1700 Switzerland
Biology Department University of Fribourg Chemin du Musée 10 Fribourg CH-1700 Switzerland
Water Quality group International Iberian Nanotechnology Laboratory (INL) Av. Mestre José Veiga s/n 4715-330 Braga Portugal
Chemistry Department University of Fribourg Chemin du Musée 9 Fribourg CH-1700 Switzerland
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