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journal article·2019-06Open access

Supramolecular Self‐Assembly of DNA with a Cationic Polythiophene: From Polyplexes to Fibers

Maxime Leclercq, Jenifer Rubio‐Magnieto, Danahe Mohammed, Sylvain Gabriele, Laurent Leclercq, Hervé Cottet, Sébastien Richeter, Sébastien Clément, Mathieu Surin

ChemNanoMat· Volume 5· Issue 6
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Source abstract

Abstract

Abstract Cationic polythiophenes constitute an interesting class of polymers for prospective applications in imaging, gene delivery and biosensing, as they combine solubility in aqueous media and have sensitive optical properties for the detection of biomolecules such as DNA. Here, we study the supramolecular self‐assembly of poly[3‐(6’‐(trimethylphosphonium)hexyl)thiophene‐2,5‐diyl] (P3HT‐PMe3) with different types of DNA such as single‐stranded oligonucleotides or long genomic DNA. Self‐assembly in buffered aqueous solution yields polyplexes (polymer/DNA complexes) with hydrodynamic radii ranging from 7 nm to around 25 nm, as observed by Taylor Dispersion Analysis. In these polyplexes, the achiral polymer presents chiroptical signals induced by supramolecular organization along chiral DNA. When the solution of long DNA/P3HT‐PMe3 is deposited on surfaces, tens of μm‐long fibers are formed by condensation of DNA and compaction of the polyplexes, as evidenced by microscopy techniques.
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Research context

Polymers

OpenAlex topics: DNA and Nucleic Acid Chemistry · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory for Chemistry of Novel Materials Center for Innovation in Materials and Polymers University of Mons – UMONS 20 Place du Parc B-7000 Mons Belgium

Current address: Bioinspired Supramolecular Chemistry and Materials Group Departament de Química Inorgànica i Orgànica Universitat Jaume I Avda Sos Baynat s/n E-12071 Castelló Spain

Mechanobiology & Soft Matter Group Laboratoire Interfaces et Fluides Complexes Center for Innovation in Materials and Polymers University of Mons – UMONS 20 Place du Parc B-7000 Mons Belgium

Institut des Biomolécules Max Mousseron (IBMM) Université de Montpellier, CNRS, ENSCM Montpellier France

Institut Charles Gerhardt (ICGM), UMR 5253 CNRS-ENSCM-UM Université de Montpellier – CC1701, Place Eugène Bataillon F-34095 Montpellier Cedex 05 France

Funding

Fonds de la Recherche Scientifique-FNRS · CNRS

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