journal article·2020-07

Double Emulsion‐Templated Single‐Core PLGA Microcapsules with Narrow Size Distribution and Controllable Structure by Using Premix Membrane Emulsification

Xiangming Na, Jianjun Guo, Tong Li, Weiqing Zhou, Guanghui Ma

ChemNanoMat· Volume 6· Issue 7
Publisher page

Abstract

Abstract A scalable and versatile strategy was developed for fabrication of double emulsion‐templated single‐core PLGA microcapsules with narrow size distribution and controllable structure. A single‐core water‐in‐oil‐in‐water (W1/O/W2) double emulsion was generated from two‐step premix membrane emulsification, which guaranteed the narrow size distribution and size controllability of emulsion. During a secondary emulsification process, coalescence of W1 droplets within oil droplet allowed multi‐core W1/O/W2 double emulsion to spontaneously transform to a single‐core one. The osmotic pressure and solvent diffusion rate were used to control the shell‐thickness and surface morphology of single‐core PLGA microcapsules, respectively. The method proposed in this study could be extended for the fabrication of uniform single‐core polymeric microcapsules with controllable structures and size.
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Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Pickering emulsions and particle stabilization · Advanced Sensor and Energy Harvesting Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences 1 North 2nd Street, Zhongguancun, Haidian District 100190 Beijing China

State Key Laboratory Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences 1 North 2nd Street, Zhongguancun, Haidian District 100190 Beijing China

State Key Laboratory Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for Stem Cell and Regeneration Chinese Academy of Sciences 1 North 2nd Street, Zhongguancun, Haidian District 100190 Beijing China

Funding

National Natural Science Foundation of China

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