journal article·2016-04Open access

Affinity of Glycan‐Modified Nanodiamonds towards Lectins and Uropathogenic Escherichia Coli

Volodymyr Turcheniuk, Kostiantyn Turcheniuk, Julie Bouckaert, Alexandre Barras, Tetiana Dumych, Rostyslav Bilyy, Vladimir Zaitsev, Aloysius Siriwardena, Qi Wang, Rabah Boukherroub, Sabine Szunerits

ChemNanoMat· Volume 2· Issue 4

Abstract

Abstract Nanodiamond particles (NDs) modified with glycan ligands are revealing themselves to have great promise as new nanomaterials for combating biofilm formation and as promising anti‐adhesive scaffolds. Currently, the strategies at hand to formulate glycan‐modified NDs (glyco‐NDs) are limited to a few reports. We demonstrate herein that the photoinduced covalent attachment of unmodified sugars results in glyco‐NDs with high binding affinity to lectins and a uropathogenic Escherichia coli strain (E. coli UTI89). While the binding affinities of glyco‐NDs to different lectins is partially sacrificed when monosaccharides such as mannose are photochemically integrated onto NDs, in the case of disaccharides and oligosaccharides the binding affinity of glyco‐NDs to lectins is preserved. Moreover, mannan‐modified NDs show strong interactions with uropathogenic E. coli., suggesting the effectiveness of photochemically formed glyco‐NDs for disruption of E. coli‐mediated biofilms.
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Research context

OpenAlex topics: Diamond and Carbon-based Materials Research · Hemoglobin structure and function · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Electronics Microelectronics and Nanotechnology (IEMN) UMR-CNRS 8520 Université Lille 1 Cité Scientifique 59655 Villeneuve d'Ascq France), Fax: (+33) 362-53-17-01

Taras Shevchenko University 60 Vladimirskaya str. Kiev 01033 Ukraine

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) CNRS UMR 8576 University Lille 59655 Villeneuve d'Ascq France

Danylo Halytsky Lviv National Medical University Pekarska str. 69 Lviv 79010 Ukraine

Chemistry Department Pontifical Catholic University of Rio de Janeiro Rua Marques de Sao Vicente, 225-Gavea Rio de Janeiro 22451-900 Brazil

Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources UMR 7378 CNRS 33 rue Saint-Leu 80039 Amiens France

Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of Education School of Materials Science and Engineering Shandong University Jinan 250061 P.R. China

Funding

Centre National de la Recherche Scientifique (CNRS) · University Lille · Nord Pas-de-Calais region · Institut Universitaire de France (IUF) · European Union

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