Cell‐Penetrating Peptides and Polymers for Improved Drug Delivery
Source abstract
Abstract
Abstract Effective delivery of biologically active compounds including peptides, proteins, and nucleic acids into cells is an obstacle in the drug research. The intracellular delivery of biological agents generally relies on the endocytosis pathway, causing them to be trapped in endosomes and lysosomes. Cell‐penetrating peptides (CPPs) have previously been shown to be a useful transport tool for delivering many kinds of goods into cells through cell membranes. The latest discovery of cell penetrating poly(disulfide)s (CPDs) with excellent cytosolic delivery efficiency represents a major breakthrough in this field. In this work, we will focus on the latest advances in biological applications of the CPPs and new opportunities opened up by the CPDs.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Dendrimers and Hyperbranched Polymers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Pharmaceutical Sciences Capital Medical University Beijing Area Major Laboratory of Peptide and Small Molecular Drugs Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China Beijing Laboratory of Biomedical Materials Beijing 100069 China
CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100190 China
Funding
National Natural Science Foundation of China
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