Black Phosphorus Nanomaterials Regulate the Aggregation of Amyloid‐β
Source abstract
Abstract
Abstract Aggregation of amyloid‐β (Aβ) plays important roles in the progression of Alzheimer's disease (AD), and various carbon‐based nanomaterials have been shown to significantly inhibit aggregation of Aβ. A new member of the family of two‐dimensional (2D) nanomaterials, black phosphorus (BP), has been successfully prepared. Compared to other nanomaterials, BP has a higher surface‐to‐volume ratio, so it has strong adsorption ability for Aβ, and can thereby regulate the aggregation of Aβ. Herein, black phosphorus (BP) nanomaterials are proposed to regulate the aggregation of Aβ for the first time, and the corresponding mechanism is clarified. This work provides new insight into the development of BP‐based strategies to prevent amyloidosis.
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Research context
OpenAlex topics: Alzheimer's disease research and treatments · Nanocluster Synthesis and Applications · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry Tsinghua University Beijing 100084 China
Center for Biomedical Materials and Interfaces, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China
Zhou Pei-Yuan Center for Applied Mathematics Tsinghua University Beijing 100084 China
Beijing Institute for Brain Disorders Beijing 100069 China
Funding
National Natural Science Foundation of China
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