Fluorescent Inorganic‐Organic Hybrid Nanoparticles
Source abstract
Abstract
Abstract Inorganic‐organic hybrid nanoparticles (IOH‐NPs) with a general composition [ZrO]2+[RDyeOPO3]2−, [Ln]3+n/3[RDye(SO3)n]n−, [Ln(OH)]2+n/2[RDye(SO3)n]n−, or [LnO]+n[RDye(SO3)n]n− (Ln: lanthanide) are a novel class of nanomaterials for fluorescence detection and optical imaging. IOH‐NPs are characterized by an extremely high load of the fluorescent dye (70–85 wt‐%), high photochemical stability, straightforward aqueous synthesis, low material complexity, intense emission and high cell uptake at low toxicity. Besides full‐color emission, IOH‐NPs are suitable for multimodal imaging, singlet‐oxygen generation as well as drug delivery and drug release. This focus review presents the material concept of the IOH‐NPs as well as their synthesis and characterization. Their characteristic features are illustrated by selected in vitro and in vivo studies to initiate application in biology and medicine.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Inorganic Chemistry Karlsruhe Institute of Technology (KIT) Engesserstraße 15 76131 Karlsruhe Germany
Translational Molecular Imaging Max-Planck-Institute for Experimental Medicine Hermann-Rein-Straße 3 37075 Göttingen Germany
Helmholtz-Center of Infection Research Inhoffenstraße 7 38124 Braunschweig Germany
Institute of Toxicology and Genetics Karlsruhe Institute of Technology (KIT) Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen Germany
Institute for Cellular and Molecular Immunology University Medical Center Göttingen (UMG) Humboldtallee 34 37073 Göttingen Germany
Funding
Studienstiftung des Deutschen Volkes
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