DataVXChemNanoMatPaper
journal article·2018-01

Gemcitabine Delivery and Photodynamic Therapy in Cancer Cells via Porphyrin‐Ethylene‐Based Periodic Mesoporous Organosilica Nanoparticles

Dina Aggad, Chiara Mauriello Jimenez, Soraya Dib, Jonas G. Croissant, Laure Lichon, Danielle Laurencin, Sébastien Richeter, Marie Maynadier, Shahad K. Alsaiari, Makhlouf Boufatit, Laurence Raehm, Marcel Garcia, Niveen M. Khashab, Magali Gary‐Bobo, Jean‐Olivier Durand

ChemNanoMat· Volume 4· Issue 1
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Source abstract

Abstract

Abstract Gemcitabine hydrochloride is an FDA‐approved chemotherapeutic drug used in the treatment of various cancers. Several drawbacks of gemcitabine, including its short in vivo half‐life of 8–17 min associated with a rapid excretion by the kidneys and its poor membrane permeability, have inspired research on a nanodelivery approach. In this study, we report ethylene‐based periodic mesoporous organosilica nanoparticles (PMOs) for photodynamic therapy and the autonomous delivery of gemcitabine in cancer cells. Porphyrins were used as photosensitizers and were localized in the walls of the PMOs while a high loading capacity of gemcitabine was observed in the porous structure. Depending on the nature of the photosensitizer, and its aggregation state, we were able to perform one or two‐photon photodynamic therapy. Two‐photon excited photodynamic therapy combined with gemcitabine delivery led to a synergy and a very efficient cancer cell killing.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Porphyrin and Phthalocyanine Chemistry · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institut des Biomolécules Max Mousseron UMR 5247 CNRS, UM-Faculté de Pharmacie Avenue Charles Flahault 34093 Montpellier cedex 05 France

Institut Charles Gerhardt Montpellier UMR-5253 CNRS-UM-ENSCM cc 1701 Place Eugène Bataillon 34095 Montpellier cedex 05 France

Smart Hybrid Materials Laboratory Advanced Membranes and Porous Materials Center King Abdullah University of Science and Technology Thuwal Saudi Arabia

NanoMedSyn Avenue Charles Flahault 34093 Montpellier cedex 05 France

Laboratoire d'Electrochimie—Corrosion, Métallurgie et Chimie Minérale Faculté de Chimie Université des Sciences et de la Technologie Houari Boumediene (U.S.T.H.B.), B.P.: 32, El-Alia Bab-Ezzouar Alger 16111 Algeria

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