Pipemidic Acid–Based Organic Cocrystal Engineering for Targeted Infected Wound Healing

Organic cocrystal engineering has emerged as a powerful strategy for designing advanced multifunctional materials, especially in complicated biomedical applications that demand both adaptability and dynamic functionality. Among these, the treatment of infected wounds, characterized by bacterial colonization, oxidative stress, and impaired tissue regeneration, remains particularly challenging. However, to date, there have been few reports utilizing organic cocrystal engineering to address these multifactorial therapeutic needs in a sustainable manner. In this study, we introduce a novel supramolecular cocrystal framework that integrates the antibiotic pipemidic acid trihydrate with the naturally derived flavonoid kaempferol into a single lattice via supramolecular synthon design. The resulting supramolecular material forms an adaptive, multifunctional architecture capable of addressing the key obstacles in infected wound healing. It effectively inhibits bacterial proliferation, attenuates oxidative damage, and promotes cellular regeneration and tissue remodeling. Experimental results demonstrate that the self-assembled cocrystals not only accelerate wound closure but also reduce systemic toxicity compared to conventional single-component antimicrobial treatments. This work highlights the potential of organic cocrystal engineering as a sustainable and synergistic therapeutic platform for advanced biomedical applications, particularly in infection-responsive wound care.