A self-powered glucose sensor based on BioCapacitor principle with micro-sized enzyme anode employing direct electron transfer type FADGDH
Source abstract
Abstract
Abstract Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin; consequently, blood glucose levels increase to become abnormally high. Accordingly, the primary treatment of diabetes is to control glycemic levels continuously. To continuously control glycemic levels, several medical devices have been developed to monitor blood glucose levels, represented by sensors and monitors for the self-monitoring of blood glucose. The ultimate goal for those engaged in research to develop medical devices is to develop implantable biodevices, namely self-powered autonomously operated artificial pancreas systems. One of the most challenging issues in realizing an implantable artificial pancreas is the long-term continuous supply of electricity, which is currently dependent on rechargeable batteries, requiring periodical replacement. In this work, we report the development of a direct electron transfer type enzyme-based miniaturized self-powered glucose sensor based on the BioCapacitor principle with a micro-sized enzyme anode area (0.15 mm × 0.75 mm), which has only 0.1 mm2 of electrode surface. As a result, a BioCapacitor utilizing a biofuel cell with a micro-sized enzyme anode was operated by self-power. In addition, the glucose concentration was detected within the range from 13 mM to 100 mM based on the frequency of charge/discharge cycles of the BioCapacitor. Although further improvement of the current density of the micro-sized anode is necessary to monitor a glucose concentration range lower than 13 mM, this self-powered glucose sensor with a micro-sized electrode based on the BioCapacitor principle was operated continuously for 6.6 h at 37 °C in 100 mM potassium phosphate buffer (pH 7.0). Our success indicates the potential to realize self-powered, autonomous, and implantable sensing modules for bio devices such as glucose-sensing systems for an artificial pancreas.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Advanced Sensor and Energy Harvesting Materials · Supercapacitor Materials and Fabrication
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (47)
Show source-provided references
1. Continuous glucose monitoring systems—current status and future perspectives of the flagship technologies in biosensor research -10.1016/j.bios.2021.113054 ↗
2. What is artificial endocrine pancreas? Mechanism and history10.3748/wjg.15.4105 ↗
3. Clinical control of diabetes by the artificial pancreas10.2337/diab.23.5.397 ↗
4. Importance of insulin secretion based on the rate of change in blood glucose concentration in glucose tolerance, assessed by the artificial beta cell10.1530/acta.0.0870339 ↗
5. Normalization of paradoxic secretion of glucagon in diabetics who were controlled by the artificial beta cell10.2337/diab.28.4.272 ↗
6. Perfect normalization of excessive glucagon responses to intravenous arginine in human diabetes mellitus with the artificial beta cell10.2337/diab.29.9.762 ↗
7. The development of biostator, a glucose controlled insulin infusion system
8. The metabolic response to glycemic control by the artificial pancreas in diabetic man10.1016/0026-0495(79)90190-2 ↗
9. Sustained insulin induced remissions of juvenile diabetes by means of an external artificial pancreas10.1007/BF01219420 ↗
10. Remote wireless control of an enzymatic biofuel cell implanted in a rabbit for 2 months10.1016/j.electacta.2018.02.156 ↗
11. Progress on implantable biofuel cell: nano-carbon functionalization for enzyme immobilization enhancement10.1016/j.bios.2016.01.016 ↗
12. A microelectronic sensor device powered by a small implantable biofuel cell10.1002/cphc.201900700 ↗
13. Challenges for successful implantation of biofuel cells10.1016/j.bioelechem.2018.05.011 ↗
14. Implantable reservoir for supplemental insulin delivery on demand be external compression10.1016/0142-9612(89)90024-0 ↗
15. Battery-free implantable insulin micropump operating at transcutaneously radio frequency‐transmittable power10.1002/mds3.10055 ↗
16. Assembly and stacking of flow-through enzymatic bioelectrodes for high power glucose fuel cells10.1021/acsami.7b06717 ↗
17. BioCapacitor: a novel principle for biosensors10.1016/j.bios.2015.07.065 ↗
18. BioCapacitor—a novel category of biosensor10.1016/j.bios.2008.09.014 ↗
19. BioRadioTransmitter: a self-powered wireless glucose-sensing system10.1177/193229681100500502 ↗
20. BioLC-oscillator: a self-powered wireless glucose-sensing system with the glucose dependent resonance frequency10.5796/electrochemistry.80.367 ↗
21. The development of an autonomous self-powered bio-sensing actuator10.1016/j.snb.2014.01.117 ↗
22. A self-powered glucose biosensing system10.1016/j.bios.2015.11.022 ↗
23. Fabrication of highly effective hybrid biofuel cell based on integral colloidal platinum and bilirubin oxidase on gold support10.1038/s41598-018-34740-w ↗
24. Tackling the challenges of enzymatic (bio)fuel cells10.1021/acs.chemrev.9b00115 ↗
25. Hybrid electronic power biodevices10.1002/celc.201402158 ↗
26. Rechargeable, flexible and mediator-free biosupercapacitor based on transparent ITO nanoparticle modified electrodes acting in µM glucose containing buffers10.1016/j.bios.2017.10.016 ↗
27. Biosupercapacitors for powering oxygen sensing devices10.1016/j.bioelechem.2015.04.012 ↗
28. Self-feeding paper based biofuel cell/self-powered hybrid μ-supercapacitor integrated system10.1016/j.bios.2016.06.084 ↗
29. Supercapacitor/biofuel cell hybrids based on wired enzymes on carbon nanotube matrices: autonomous reloading after high power pulses in neutral buffered glucose solutions10.1039/C3EE43986K ↗
30. Highly sensitive and stable fructose self-powered biosensor based on a self-charging biosupercapacitor10.1016/j.bios.2020.112909 ↗
31. Continuous operation of an ultra-low-power microcontroller using glucose as the sole energy source10.1016/j.bios.2016.09.095 ↗
32. Cloning and functional expression of glucose dehydrogenase complex of Burkholderia cepacia in Escherichia coli10.1016/j.jbiotec.2005.10.017 ↗
33. Essential role of the small subunit of thermostable glucose dehydrogenase from Burkholderia cepacia10.1007/s10529-004-4582-0 ↗
34. Subunit analyses of a novel thermostable glucose dehydrogenase showing different temperature properties according to its quaternary structure10.1385/ABAB:77:1-3:325 ↗
35. A novel thermostable glucose dehydrogenase varying temperature properties by altering its quaternary structures10.1016/0141-0229(95)00170-0 ↗
36. Direct electron transfer (DET) mechanism of FAD dependent dehydrogenase complexes ∼ from the elucidation of intra- and inter-molecular electron transfer pathway to the construction of engineered DET enzyme complexes10.1016/j.coelec.2018.07.013 ↗
37. An Fe–S cluster in the conserved Cyc-rich region in the catalytic subunit of FAD-dependent dehydrogenase complexes10.1016/j.bioelechem.2016.01.010 ↗
38. Three-dimensional nickel foam based enzymatic electrode and its glucose/O2 biofuel cell with high power density10.1149/2.0761713jes ↗
39. FAD-based glucose dehydrogenase immobilized on thionine/AuNPs frameworks grafted on amino-CNTs: development of high power glucose biofuel cell and biosensor10.1016/j.jelechem.2018.02.064 ↗
40. A high power buckypaper biofuel cell: exploiting 1,10-phenanthroline-5,6-dione with FAD-dependent dehydrogenase for catalytically-powerful glucose oxidation10.1021/acscatal.7b00738 ↗
41. High-power lactate/O2 enzymatic biofuel cell based on carbon cloth electrode modified with MgO-templated carbon10.1016/j.jpowsour.2019.226844 ↗
42. High-performance glucose biosensor based on chitosan-glucose oxidase immobilized polypyrrole/Nafion/functionalized multi-walled carbon nanotubes bio-nanohybrid film10.1016/j.jcis.2016.07.067 ↗
43. Structuring Au nanoparticles on two-dimensional MoS2 nanosheets for electrochemical glucose biosensors10.1016/j.bios.2016.03.024 ↗
44. A pacemaker powered by an implantable biofuel cell operating under conditions mimicking the human blood circulatory system-battery not included10.1039/c3cp50929j ↗
45. A symmetric supercapacitor/biofuel cell hybrid device based on enzyme-modified nanoporous gold: an autonomous pulse generator10.1016/j.bios.2016.11.012 ↗
46. Effects of pore size and surface properties of MgO-templated carbon on the performance of bilirubin oxidase-modified oxygen reduction reaction cathode10.1016/j.electacta.2019.134744 ↗
47. Membraneless enzymatic ethanol/O2 fuel cell: transitioning from an air-breathing Pt-based cathode to a bilirubin oxidase-based biocathode10.1016/j.jpowsour.2016.05.073 ↗