journal article·2024-08-13

Host–Guest Strategy for Organic Phosphorescence to Generate Oxygen Radical over Singlet Oxygen

Lingling Kang, Cong Chao, Chenchen Xiong, Shuang Yu, Changtao Xiao, Changsheng Zhao, Shisheng Cui, Jiguang Li, Jing Li, Jianbing Shi, Bin Tong, Zhuo Wang, Yin Song, Weiqian Zhao, Zhengxu Cai, Yuping Dong

Chemistry of Materials· Volume 36· Issue 15
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Abstract

Exciton dynamics exert a pivotal role in the photodynamic efficiency of photosensitizers, however, strategies for modulating exciton dynamics to motivate electron transfer in exciton-involved photoreactions remain largely unexplored. Herein, we employed a cutting-edge microfluidic platform combined with computational fluid dynamics to encapsulate a commercial type II PS [rose Bengal (RB)] within a rigid host matrix. This encapsulation yielded host/RB nanoparticles (NPs) with a uniform structure and controllable size. The photoexcited dynamics of these host/RB NPs were characterized using time-resolved spectroscopy, and the results revealed that encapsulation not only extended the triplet exciton lifetime of RB, but also created an optimized environment to motivate electron transfer between RB molecules. These findings rationalize the observed remarkable 20-fold reduction in type II photoreaction and a 3-fold promotion in type I photoreaction for host/RB NPs. Due to the dramatic generation of HO • and O 2 •–, host/RB NPs demonstrated excellent ability for the in vitro eradication of Staphylococcus aureus and Escherichia coli biofilms and the in vivo treatment of S. aureus -infected wounds under hypoxia, with a minimum killing concentration of 10 –7 M. This work sheds light on the motivation of exciton transfer to develop type I PS with enhanced photodynamic properties.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China

Beijing Key Laboratory of Emission Surveillance and Control for Thermal Power Generation, North China Electric Power University, Beijing 102206, China

MIIT Key Laboratory of Complex-Field Intelligent Exploration, School of Optics and Photonics, Beijing Institute of Technology, Beijing 10081, China

Department of Orthopedics, Peking University International Hospital, Beijing 102206, China

State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Funding

National Key Research and Development Program of China · Natural Science Foundation of Beijing Municipality · Beijing Institute of Technology · National Natural Science Foundation of China

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