pH-Sensitive Polymer–Drug Conjugates
Source abstract
Abstract
Polymer–drug conjugates (PDCs) were introduced with the goal of improving the properties of drug molecules, such as their solubility, blood circulation time, and tissue targeting. Since the first examples dating back decades, substantial progress has been made in the design and implementation of linkages that enable the selective release of drugs in response to physiological stimuli associated with various pathologies. Among these stimuli, a change in pH from neutral to mildly acidic has been one of the most widely exploited. This perspective will discuss the advantages and limitations of different linker strategies and their applications in the development of PDCs to treat cancer, inflammation, and bacterial infection. These materials range from soluble linear and branched polymer systems to nanoparticles, hydrogels, and coatings. Both an historical perspective and recent developments will be presented. Finally, some ongoing challenges will be discussed, along with opportunities for future work.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Polymer Synthesis and Characterization · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, Department of Chemical and Biochemical Engineering, School of Biomedical Engineering, The University of Western Ontario, London, Ontario N6A 5B7, Canada
Funding
Canada Research Chairs · Natural Sciences and Engineering Research Council of Canada
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