DataVXChemistry of MaterialsPaper
journal article·2022-12-27Open access

Thermoresponsive Triblock Copolymers as Widely Applicable 19F Magnetic Resonance Imaging Tracers

Kristyna Kolouchova, Ondrej Groborz, Miroslav Slouf, Vit Herynek, Laurens Parmentier, David Babuka, Zulfiya Cernochova, Filip Koucky, Ondrej Sedlacek, Martin Hruby, Richard Hoogenboom, Sandra Van Vlierberghe

Chemistry of Materials· Volume 34· Issue 24
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Abstract

Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broadening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermoresponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle- and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line.
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Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Lanthanide and Transition Metal Complexes · Advanced MRI Techniques and Applications · Advanced NMR Techniques and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Polymer Chemistry and Biomaterials Group, Centre of Macromolecular Chemistry, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-Bis, 9000Ghent, Belgium

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského sq. 2, 162 06Prague 6, Czech Republic

Institute of Biophysics and Informatics, Charles University, First Faculty of Medicine, Salmovská 1, 120 00Prague 2, Czech Republic

Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo sq. 2, 160 00Prague 6, Czech Republic

Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovská 3, 120 00Prague 2, Czech Republic

Department of Inorganic Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 43Praha 2, Czech Republic

Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 128 40Prague 2, Czech Republic

Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Centre of Macromolecular Chemistry, Ghent University, Krijgslaan 281-S4, 9000Ghent, Belgium

Funding

European Regional Development Fund · Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy · Technologick? Agentura Cesk? Republiky · Fonds Wetenschappelijk Onderzoek

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