DataVXChemistry of MaterialsPaper
journal article·2020-07-14

Radical-Enriched Artificial Melanin

Wei Cao, Alex J. Mantanona, Haochuan Mao, Naneki C. McCallum, Yang Jiao, Claudia Battistella, Valeria Caponetti, Nanzhi Zang, Matthew P. Thompson, Marco Montalti, J. Fraser Stoddart, Michael R. Wasielewski, Jeffrey D. Rinehart, Nathan C. Gianneschi

Chemistry of Materials· Volume 32· Issue 13
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Source abstract

Abstract

Melanin is a class of ubiquitous, heterogeneous, polymeric pigments. One of the most unusual features of melanin is the presence of stable persistent radicals, which has been reported to relate to ionizing radiation protection, including X-rays and gamma rays. In this work, we aimed to increase the radical content by introducing nitroxide radicals into synthetic melanin nanomaterials. Nanoparticles (NPs) were prepared by copolymerization of a stable radical modified monomer with the monomer dopamine. The radical content increased to 1 order of magnitude higher than that of the conventional melanin-like material, polydopamine. These radical NPs can enter human epidermal keratinocytes and form perinuclear caps, mimicking natural melanin synthesized by melanocytes. We demonstrated that these NPs display protective properties by scavenging reactive oxygen species, one of the most important biological effects of ionizing radiation exposure. This finding may have potential application for materials capable of mitigating side effects of clinical radiation therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Skin Protection and Aging · melanin and skin pigmentation · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Northwestern University, Evanston, Illinois 60208, United States

Chemistry of Life Processes Institute, Lurie Cancer Center, Northwestern University, Evanston, Illinois 60208, United States

Department of Biomedical Engineering, Chemistry of Life Processes Institute, Lurie Cancer Center, Northwestern University, Evanston, Illinois 60208, United States of America

International Institute of Nanotechnology, Chemistry of Life Processes Institute, Lurie Cancer Center, Northwestern University, Evanston, Illinois 60208, United States

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States

Institute for Sustainability and Energy at Northwestern University, Evanston, Illinois 60208, United States

Dipartimento di Chimica “G. Ciamician”, Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy

Institute of Molecular Design and Synthesis, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China

School of Chemistry, University of New South Wales, Sydney, New South Wales 2052, Australia

Funding

Air Force Office of Scientific Research · Northwestern University

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