Synthesis of Binary Nanopatterns on Hydrogels for Initiating Cellular Responses

Judith Guasch; Jennifer Diemer; Hossein Riahinezhad; Stefanie Neubauer; Horst Kessler; Joachim P. Spatz

doi:10.1021/acs.chemmater.5b04910

journal article·2016-03-22

Synthesis of Binary Nanopatterns on Hydrogels for Initiating Cellular Responses

Judith Guasch, Jennifer Diemer, Hossein Riahinezhad, Stefanie Neubauer, Horst Kessler, Joachim P. Spatz

Chemistry of Materials· Volume 28· Issue 6

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Source abstract

Abstract

We describe the synthesis of binary nanostructures consisting of PEG hydrogels decorated with arrays of AuNPs and TiO 2 NPs, and their orthogonal functionalization with various peptides. These ligands are able to promote or elude cell adhesion through integrins, a family of transmembrane receptors that connect cells with the extracellular matrix (ECM) or other cells. The different cell adhesion behaviors observed depending on the peptides used, proved the functionality of such binary nanopatterns, which we expect to find applications not only in tissue engineering but also in smart cell culture systems and biosensors.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials Biomaterials

OpenAlex topics: 3D Printing in Biomedical Research · Nanoparticle-Based Drug Delivery · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Heisenbergstrasse 3, D-70569 Stuttgart, Germany

Department of Biophysical Chemistry, University of Heidelberg, Im Neuenheimer Feld 253, D-69120 Heidelberg, Germany

Institute for Advanced Study (IAS) and Center of Integrated Protein Science (CIPSM), Department Chemie, Technische Universität München, Lichtenbergstr. 4, Garching D-85747, Germany

Funding

Research Executive Agency · Bundesministerium f?r Bildung und Forschung · European Research Council · Max-Planck-Gesellschaft

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