Monodisperse, Charge-Stabilized, Core–Shell Particles via Silica-Supported Reversible Addition–Fragmentation Chain Transfer Polymerization for Cell Imaging
Source abstract
Abstract
We describe the formation of monodisperse silica–polymer core–shell particles of tunable particle sizes. Incorporation of a comonomer in the surface-initiated reversible addition–fragmentation chain transfer (RAFT) polymerization resulted in fluorescent particles, which were further functionalized to yield hydrophilic, highly uniform particles that are sterically stable in biologically relevant conditions. The particles were further shown to adhere to the walls and be endocytosed into the human colon cancer cells, allowing the cells to be imaged using confocal microscopy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Polymer Synthesis and Characterization · Polymer Surface Interaction Studies · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Centre for Polymers & Colloids, School of Chemistry, The University of Sydney, NSW 2006, Australia.
Division of Materials Chemistry, Institute for Chemical Research, Kyoto University, Kyoto 611-0011, Japan.
Laboratory of Advanced Catalysis for Sustainability, School of Chemistry, The University of Sydney, NSW 2006, Australia
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