DataVXChemistry of MaterialsPaper
journal article·2017-10-10Open access

Harnessing Surface-Functionalized Metal–Organic Frameworks for Selective Tumor Cell Capture

Xiaoyue Qi, Ziyong Chang, Duo Zhang, Kellie J. Binder, Sensen Shen, Yan Yan Shery Huang, Yu Bai, Andrew E. H. Wheatley, Huwei Liu

Chemistry of Materials· Volume 29· Issue 19
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Source abstract

Abstract

A platform based on a metal-organic framework (MOF) bearing free carboxylic acid groups has been developed for tumor cell capture and potential drug screening applications. A zinc-based MOF expressing uncoordinated carboxylic acids (ZnMOF-COOH) was grown on a ZnO substrate. Post-synthetic modification (PSM) of the acid groups gave a composite material that expressed peptide linkages and allowed the immobilization of anti-epithelial cell adhesion molecule (anti-EpCAM) antibody. This strategy offers a universal method for the controllable immobilization of antibodies and even enzymes on the surface of a MOF. The resulting immunotrapper exhibited excellent capture ability, demonstrating high efficiency and selectivity towards EpCAM-positive tumor cells. The promotion of tumor cell adhesion is attributed to the 3-dimentional (3D) structure of the composite, which revealed spine-like microstructures.
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Research context

Composites

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Nanoplatforms for cancer theranostics · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

School of Chemical Engineering, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia

Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, United Kingdom

Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom

Funding

Engineering and Physical Sciences Research Council · National Natural Science Foundation of China

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