Biocompatible Hydrophilic Modifications of Poly(dimethylsiloxane) Using Self-Assembled Hydrophobins

Wettability improvement and bioactive interface designing of poly(dimethylsiloxane) (PDMS) are keen for its application in biodevices. Herein we developed a fully biocompatible approach for achieving stable hydrophilic surfaces by modifying PDMS with hydrophobins. X-ray photoelectron spectroscopy (XPS), water contact angle (WCA), and the force curve measurements demonstrated the conversion of the surface properties from hydrophobic to hydrophilic. The patterning of antigen molecules and the following immunoassays illustrated that this method should be a feasible strategy for bioactive surface modification in biosensing devices.