Organophosphonate Functionalized Gd@C82 as a Magnetic Resonance Imaging Contrast Agent
Source abstract
Abstract
A new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM −1 s −1 ) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM −1 s −1 ) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C 82 (16.0 mM −1 s −1 ) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · Magnetism in coordination complexes · Advanced NMR Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China, Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24060, Department of Radiology, Virginia Commonwealth University, Richmond, Virginia 23298, and Centre for Materials Research, Queen Mary, University of London, London E1 4NS, U.K.
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