Cross-Linked Small-Molecule Micelle-Based Drug Delivery System: Concept, Synthesis, and Biological Evaluation
Source abstract
Abstract
Lessons from the covalent capture of small-molecule self-assemblies (monomer molecular weight of <500.0) are applied to grow a generic cross-linked small-molecule micelle-based drug delivery system (CSM-DDS), which has significant advantages over the popular polymeric micelle-based drug delivery systems in terms of drug loading, stability, monomer purity, and cost of preparation. A proof-of-concept CSM-DDS constructed by one-step synthesized amphiphile 1 with anticancer drug gemcitabine confirms the feasibility of the new strategy via its high drug loading content (up to 58%), robust stability, superior predictable biosafety, facile functionalization, and remarkable anticancer activity both in vitro and in vivo .
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Polymer Synthesis and Characterization · Dendrimers and Hyperbranched Polymers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China
Funding
National Natural Science Foundation of China · Central Committee of the Communist Party of China · Sichuan Province · Setup Foundation, Sichuan University · Excellent Young Foundation of Sichuan Province
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