Synthesis of Ultrasensitive Magnetic Resonance Contrast Agents for Cancer Imaging Using PEG-Fatty Acid
Source abstract
Abstract
Diagnosis of cancer in the early stages requires sensitive magnetic resonance (MR) probes to detect low concentrations of magnetic substances. In this study, ultrasensitive magnetic resonance contrast agents (UMRCAs) composed of magnetic nanocrystals and amphiphilic block copolymers were synthesized for cancer detection using polyethylene glycol and fatty acid. The chemical structures and the compositions of PEGylated magnetic nanoparticles were analyzed. UMRCAs displayed remarkable colloidal stability and high sensitivity as MR probes. Furthermore, UMRCAs exhibited low cytotoxicity and excellent cancer detection ability in an in vivo animal model.
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Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Engineering, College of Engineering, Yonsei University, Seoul 120-749, Republic of Korea, ATGen, Advanced Technology Research Center, 68 Yatap-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-816, South Korea, Department of Physics, College of Natural Science, Ajou University, Suwon 433-749, South Korea, Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, South Korea, and Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic...
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