journal article·2024-09-10Open access

Molecular Engineering of Red Aggregation-Induced Emission Luminogens with Small Conjugated Structures

Ziqiong Huang, Jufang Yang, Jianshuo Cheng, Lulu Zhou, Chunrui Zhao, Shen Shen, Glib Baryshnikov, Hans Ågren, Qi Zou, Liangliang Zhu

Chemistry of Materials· Volume 36· Issue 17

Abstract

Design strategies for red/near-infrared aggregation-induced emission luminogens (AIE-gens) with biological applications still face significant challenges as the conventional π-conjugated extension requires complex synthesis routes and usually suffers from poor solubility. Herein, we propose a delicate strategy for red emission through AIE of small conjugated structures, hexaselenobenzene derivatives (6SeBA and 6SeBPI), with the assistance of the heavy atom effect from the substitution of selenium. The hexaselenobenzene core exhibits both the AIE effect and efficient triplet-state emission. Through molecular engineering, 6SeBA exhibits bright and stable red photoluminescence at 650 nm with a large Stokes shift, and 6SeBPI shows dual emission bands, further demonstrating the dynamical monitoring of cellular processes via multichannel imaging. In addition, 6SeBPI can generate a greater quantity of reactive oxygen species upon exposure to light, thereby conferring the potential for photodynamic immunotherapy. This strategy provides insights into the design of red AIE luminogens with shorter conjugated scales, paving the way for simultaneous imaging and therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Molecular Sensors and Ion Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China

Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power, Shanghai 200090, China

Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping SE-60174, Sweden

Department of Physics and Astronomy, Uppsala University, Uppsala SE-751 20, Sweden

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China

Funding

Vetenskapsr?det · European Research Council · Link?pings Universitet · National Natural Science Foundation of China

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